Chemical modification based on diterpene alkaloids — New derivatives of karakoline and talatisidine

1994 ◽  
Vol 30 (4) ◽  
pp. 480-482
Author(s):  
A. A. Nishanov ◽  
M. N. Sultankhodzhaev
Keyword(s):  
Chemical Modification ◽  
Diterpene Alkaloids ◽  
Derivatives Of

scholarly journals Chemical modification of herbimycin A. Synthesis and in vivo antitumor activities of halogenated and other related derivatives of herbimycin A.

1986 ◽  
Vol 39 (3) ◽  
pp. 415-423 ◽  
Author(s):  
KIYOSHI SHIBATA ◽  
SADAYOSHI SATSUMABAYASHI ◽  
HIROSHI SANO ◽  
KANKI KOMIYAMA ◽  
AKIRA NAKAGAWA ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Antitumor Activities ◽  
Herbimycin A ◽  
Derivatives Of

Chemical Modification of Cotton with Derivatives of Divinyl Sulfone

1961 ◽  
Vol 31 (4) ◽  
pp. 283-295 ◽  
Author(s):  
Giuliana C. Tesoro ◽  
Paul Linden ◽  
Stephen B. Sello
Keyword(s):  
Chemical Modification ◽  
Divinyl Sulfone ◽  
Derivatives Of

scholarly journals Aconitum lipo-alkaloids – Semisynthetic Products of the Traditional Medicine

2011 ◽  
Vol 6 (4) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Botond Borcsa ◽  
Dezső Csupor ◽  
Peter Forgo ◽  
Ute Widowitz ◽  
Rudolf Bauer ◽  
...  
Keyword(s):  
Complex Mixture ◽  
Long Chain Fatty Acid ◽  
Diterpene Alkaloids ◽  
Highly Sensitive ◽  
Minor Compounds ◽  
The Individual ◽  
Traditional Processing ◽  
Far Eastern ◽  
Derivatives Of ◽  
General Method

The term lipo-alkaloid is used for C19 aconitane alkaloids containing one or two long-chain fatty acid residues. Lipo-alkaloids are transesterified derivatives of the most toxic and highly effective diester-type diterpene alkaloids, such as aconitine, hypaconitine, mesaconitine. Lipo-alkaloids are native minor compounds of aconite drugs, but their amount significantly increases after traditional processing, which is a general method in the Far Eastern traditional medicinal systems. Analytical works demonstrated that cautious processing (usually boiling) of crude aconite roots decreases the amount of normal diterpene alkaloids and increases the concentration of lipo-alkaloids resulting in the reduction of toxicity of the drugs. Many papers reported that lipo-alkaloids occur as a complex mixture in the drugs, and the isolation of the individual components is extremely difficult. These compounds have been identified using highly sensitive analytical methods (HPLC-MS, NMR), and semisynthetic approaches have been developed to ensure lipo-alkaloids in pure form for pharmacological studies. This review summarizes the structure, chemistry, semisynthesis, analytics and bioactivities of lipo-alkaloids. On the basis of 32 references this is the first comprehensive study on this topic, covering the data of 173 compounds.

scholarly journals The use of deoxyfluoro-d-glucopyranoses and related compounds in a study of yeast hexokinase specificity

1972 ◽  
Vol 128 (2) ◽  
pp. 199-204 ◽  
Author(s):  
E. M. Bessell ◽  
A. B. Foster ◽  
J. H. Westwood
Keyword(s):  
Chemical Modification ◽  
Substrate Binding ◽  
Hexokinase 2 ◽  
Substantial Loss ◽  
Methyl Derivatives ◽  
Derivatives Of ◽  
Related Compounds ◽  
Yeast Hexokinase

1. 2-Deoxy-2-fluoro-d-glucose, 2-deoxy-2-fluoro-d-mannose and 2-deoxy-2,2-difluoro-d-arabino-hexose are good substrates for yeast hexokinase. 2. 3-Deoxy-3-fluoro-d-glucose and 4-deoxy-4-fluoro-d-glucose are poor substrates and have very similar Km values (8×10−2m). 3. Neither α- nor β-d-glucopyranosyl fluoride is a substrate or inhibitor. 4. Studies with 2-chloro-2-deoxy- and 2-O-methyl derivatives of d-glucose and d-mannose have revealed that little chemical modification is possible at position 2 without substantial loss in substrate binding. 5. The variation in the value of Km for the d-hexose derivatives was associated with a corresponding change in the value of Km for MgATP2− showing that the binding of MgATP2− is modified by the binding of the sugar.

scholarly journals Chemical modification of spiramycins I. Synthesis of the acetal derivatives of neospiramycin I.

1983 ◽  
Vol 36 (10) ◽  
pp. 1336-1344 ◽  
Author(s):  
HIROSHI SANO ◽  
MICHI INOUE ◽  
KINYA YAMASHITA ◽  
RYO OKACHI ◽  
SATOSHI OMURA
Keyword(s):  
Chemical Modification ◽  
Derivatives Of
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