Electrochemical synthesis in an undivided cell of aromatic mono and dichalcogeno derivatives by SRN1 substitution reactions in MeCN

1993 ◽  
Vol 23 (11) ◽  
pp. 1125-1131 ◽  
Author(s):  
M. Genesty ◽  
C. Thobie ◽  
A. Gautier ◽  
C. Degrand
Keyword(s):  
Electrochemical Synthesis ◽  
Substitution Reactions ◽  
Undivided Cell

Electrochemical synthesis of α,β-(E)-unsaturated esters in undivided cell (Horner–Emmons reaction)

2003 ◽  
Vol 5 (6) ◽  
pp. 455-459 ◽  
Author(s):  
Agustı́n Palma ◽  
Bernardo A. Frontana-Uribe ◽  
Jorge Cárdenas ◽  
Miguel Saloma
Keyword(s):  
Electrochemical Synthesis ◽  
Unsaturated Esters ◽  
Undivided Cell

scholarly journals Electrochemical Synthesis of Sulfinate Esters: Nickel(II)-Catalyzed Oxidative Esterification of Thiols with Alcohols in an Undivided Cell

ACS Omega ◽  
2020 ◽  
Vol 5 (29) ◽  
pp. 17947-17954
Author(s):  
Babak Kaboudin ◽  
Leila Behrouzi ◽  
Foad Kazemi ◽  
Mohammad M. Najafpour ◽  
Hiroshi Aoyama
Keyword(s):  
Electrochemical Synthesis ◽  
Oxidative Esterification ◽  
Undivided Cell ◽  
Sulfinate Esters

Spatiotemporal Control of Amide Radicals During Photocatalysis

2020 ◽  
Author(s):  
Shogo Mori ◽  
Takahiro Aoki ◽  
Kaliyamoorthy Selvam ◽  
Shunichi Fukuzumi ◽  
Jieun Jung ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Nickel Complex ◽  
Nickel Complexes ◽  
Semiconductor Material ◽  
Radical Reactions ◽  
Substitution Reactions ◽  
Carbon Neutrality ◽  
Spatiotemporal Control ◽  
Scalable Production ◽  
Salt Waste

Despite the continuing popularity of radical reactions in organic synthesis, much remains to be explored in this area. Herein, we describe how spatiotemporal control can be exerted over the formation and reactivity of divergent exchangeable formamide radicals using nickel complexes with a semiconductor material (TiO<sub>2</sub>) under irradiation from near-UV–Vis light. Depending on the bipyridine ligand used and the quantity of the nickel complex that is hybridized on or nonhydridized over the TiO<sub>2</sub> surface, these radicals selectively undergo substitution reactions at the carbon center of carbon–bromine bonds that proceed via three different pathways. As the scalable production of formamides from CO<sub>2</sub> does not produce salt waste, these methods could add a new dimension to the search for carbon neutrality through the indirect incorporation of CO<sub>2</sub> into organic frameworks.

Tele-Substitution Reactions in the Synthesis of a Promising Class of Antimalarials

2020 ◽  
Author(s):  
Marat Korsik ◽  
Edwin Tse ◽  
David Smith ◽  
William Lewis ◽  
Peter J. Rutledge ◽  
...  
Keyword(s):  
Heterocyclic Ring ◽  
Ring System ◽  
Substitution Reactions ◽  
Laboratory Notebook ◽  
Polar Solvents ◽  
X Ray ◽  
X Ray Crystallography ◽  
The Core ◽  
Nmr Data

<p></p><p>We have discovered and studied a <i>tele</i>substitution reaction in a biologically important heterocyclic ring system. Conditions that favour the <i>tele</i>-substitution pathway were identified: the use of increased equivalents of the nucleophile or decreased equivalents of base, or the use of softer nucleophiles, less polar solvents and larger halogens on the electrophile. Using results from X-ray crystallography and isotope labelling experiments a mechanism for this unusual transformation is proposed. We focused on this triazolopyrazine as it is the core structure of the <i>in vivo </i>active anti-plasmodium compounds of Series 4 of the Open Source Malaria consortium.</p> <p> </p> <p>Archive of the electronic laboratory notebook with the description of all conducted experiments and raw NMR data could be accessed via following link <a href="https://ses.library.usyd.edu.au/handle/2123/21890">https://ses.library.usyd.edu.au/handle/2123/21890</a> . For navigation between entries of laboratory notebook please use file "Strings for compounds in the article.pdf" that works as a reference between article codes and notebook codes, also this file contain SMILES for these compounds. </p><br><p></p>

ELECTROCHEMICAL SYNTHESIS OF NANOSTRUCTURED COATING BASED ON TITANIUM DIOXIDE

2017 ◽  
Vol 62 ◽  
pp. 171-177
Author(s):  
D. V. Suvorov ◽  
◽  
G. P. Gololobov ◽  
M. А. Serpova ◽  
Yu. M. Stryuchkova ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Electrochemical Synthesis ◽  
Nanostructured Coating

The Chemistry of Triazine Isomers: Structures, Reactions, Synthesis and Applications

2020 ◽  
Vol 20 ◽  
Author(s):  
Neelottama Kushwaha ◽  
C S Sharma
Keyword(s):  
Basic Property ◽  
Electrophilic Substitution ◽  
Antimicrobial Agents ◽  
Resonance Energy ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Agricultural Fields ◽  
Substitution Reactions ◽  
Anti Cancer ◽  
Benzene Structure

: Triazine is the six-membered heterocyclic ring containing three nitrogen which replaces carbon-hydrogen unit in the benzene ring. Based on nitrogen position present in the ring system, it is categorized in three isomeric forms i.e.1, 2, 3-triazine (vicinal triazine), 1, 2, 4-triazine (asymmetrical triazine or isotriazine) and 1, 3, 5-triazine (symmetrical or s-triazine or cyanidine). Triazines have weakly basic property. Its isomers have much weaker resonance energy than benzene structure, so nucleophilic substitution reactions are more preferred than electrophilic substitution reactions. Triazine isomers and their derivatives are known to play important roles possessing various activities in medicinal and agricultural fields such as anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal, antimalarial and antimicrobial agents.

Synthesis and Evaluation of Antioxidant, Antimicrobial and Anticancer Properties of 2-(Prop-2-yn-1-yloxy)benzaldehyde Derivatives

2019 ◽  
Vol 16 (5) ◽  
pp. 415-423
Author(s):  
Metin Konus ◽  
Selahattin Aydemir ◽  
Can Yilmaz ◽  
Arif Kivrak ◽  
Aslihan Kurt Kizildogan ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Breast Adenocarcinoma ◽  
Substitution Reactions ◽  
Anticancer Properties ◽  
Microdilution Method ◽  
Agar Disc ◽  
Broth Microdilution Method ◽  
Total Antioxidant ◽  
Benzaldehyde Derivatives ◽  
High Antifungal Activity

5-bromo-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 3) and 3,5-di-tert-butyl-2-(prop-2- yn-1-yloxy)benzaldehyde (compound 5) were synthesized via nucleophilic substitution reactions. Compound 5 showed higher antioxidant capacity with respect to compound 3 in all the four different antioxidant activity methods used. Moreover, in phosphomolybdenum assay, compound 5, with 1.1 proportion value, showed almost the same total antioxidant capacity compared to universal trolox standard. Furthermore, Broth microdilution method and agar disc diffusion tests demonstrated that the same compound also exhibited good antibacterial activity towards the bacteria Bacillus subtilis. Finally, both of the benzaldehyde compounds showed high antifungal activity against Aspergillus niger. In this study, compound 5 (IC50: 54.3 µg/ml) showed significant cytotoxic activity against breast adenocarcinoma cell line MCF-7 with respect to compound 3 (IC50: 173.4 µg/ml).

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