Papierchromatographische Auftrennung eines Schlangengiftes (Vipera ammodytes mont.)

1955 ◽  
Vol 42 (20) ◽  
pp. 558-559 ◽  
Author(s):  
H. W. Raudonat
Keyword(s):  
Vipera Ammodytes

scholarly journals Intravenous Vipera berus Venom-Specific Fab Fragments and Intramuscular Vipera ammodytes Venom-Specific F(ab’)2 Fragments in Vipera ammodytes-Envenomed Patients

Toxins ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 279
Author(s):  
Tihana Kurtović ◽  
Svjetlana Karabuva ◽  
Damjan Grenc ◽  
Mojca Dobaja Borak ◽  
Igor Križaj ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Clinical Signs ◽  
Length Of Hospital Stay ◽  
Vipera Berus ◽  
Fab Fragments ◽  
Elimination Half ◽  
Apparent Total Body Clearance ◽  
Total Body ◽  
A Prospective Study ◽  
Vipera Ammodytes

Vipera ammodytes (V. ammodytes) is the most venomous European viper. The aim of this study was to compare the clinical efficacy and pharmacokinetic values of intravenous Vipera berus venom-specific (paraspecific) Fab fragments (ViperaTAb) and intramuscular V. ammodytes venom-specific F(ab’)2 fragments (European viper venom antiserum, also called “Zagreb” antivenom) in V.ammodytes-envenomed patients. This was a prospective study of V.ammodytes-envenomed patients that were treated intravenously with ViperaTAb or intramuscularly with European viper venom antiserum that was feasible only due to the unique situation of an antivenom shortage. The highest venom concentration, survival, length of hospital stay and adverse reactions did not differ between the groups. Patients treated with intravenous Fab fragments were sicker, with significantly more rhabdomyolysis and neurotoxicity. The kinetics of Fab fragments after one or more intravenous applications matched better with the venom concentration in the early phase of envenomation compared to F(ab’)2 fragments that were given intramuscularly only on admission. F(ab’)2 fragments given intramuscularly had 25-fold longer apparent total body clearance and 14-fold longer elimination half-time compared to Fab fragments given intravenously (2 weeks vs. 24 h, respectively). In V.ammodytes-envenomed patients, the intramuscular use of specific F(ab’)2 fragments resulted in a slow rise of antivenom serum concentration that demanded their early administration but without the need for additional doses for complete resolution of all clinical signs of envenomation. Intravenous use of paraspecific Fab fragments resulted in the immediate rise of antivenom serum concentration that enabled their use according to the clinical progress, but multiple doses might be needed for efficient therapy of thrombocytopenia due to venom recurrence, while the progression of rhabdomyolysis and neurotoxic effects of the venom could not be prevented.

scholarly journals Subfractionation and recombination of a neurotoxic complex from the venom of the bulgarian viper (Vipera ammodytes ammodytes)

FEBS Letters ◽  
1977 ◽  
Vol 76 (2) ◽  
pp. 266-268 ◽  
Author(s):  
B. Tchorbanov ◽  
B. Aleksiev ◽  
T. Bukolova-Orlova ◽  
E. Burstein ◽  
B. Atanasov
Keyword(s):  
Vipera Ammodytes

Fractionation of Vipera ammodytes venom and seasonal variation of its composition

Toxicon ◽  
1974 ◽  
Vol 12 (2) ◽  
pp. 167-168 ◽  
Author(s):  
F. Gubenšek ◽  
D. Sket ◽  
V. Turk ◽  
D. Lebez
Keyword(s):  
Seasonal Variation ◽  
Vipera Ammodytes

Action of a partially purified basic protein fraction from Vipera ammodytes venom

Toxicon ◽  
1973 ◽  
Vol 11 (1) ◽  
pp. 47-53 ◽  
Author(s):  
D. Sket ◽  
F. Gubenšek ◽  
Š. Adamič ◽  
D. Lebez
Keyword(s):  
Protein Fraction ◽  
Basic Protein ◽  
Vipera Ammodytes

The C-terminal and β-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect

Biochimie ◽  
2006 ◽  
Vol 88 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Petra Prijatelj ◽  
Marlène Charnay ◽  
Gabriela Ivanovski ◽  
Zala Jenko ◽  
Jože Pungerčar ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Factor Xa ◽  
Anticoagulant Effect ◽  
Vipera Ammodytes
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