Herpesvirus hominis specific antigen in cells of human malignant glioma

1972 ◽  
Vol 59 (9) ◽  
pp. 424-424 ◽  
Author(s):  
K. Munk ◽  
Gh. Darai ◽  
V. Kansteiner ◽  
H. Penzholz
Keyword(s):  
Malignant Glioma ◽  
Specific Antigen ◽  
Human Malignant Glioma ◽  
Herpesvirus Hominis ◽  
In Cells

Radiation-Induced DNA Damage and Repair in Cells of a Radiosensitive Human Malignant Glioma Cell Line

1995 ◽  
Vol 144 (3) ◽  
pp. 288 ◽  
Author(s):  
M. Joan Allalunis-Turner ◽  
Peter K. Y. Zia ◽  
Geraldine M. Barron ◽  
Razmik Mirzayans ◽  
Rufus S. Day
Keyword(s):  
Dna Damage ◽  
Malignant Glioma ◽  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Dna Damage And Repair ◽  
Human Malignant Glioma ◽  
Radiation Induced ◽  
In Cells

Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells

1996 ◽  
Vol 84 (5) ◽  
pp. 831-838 ◽  
Author(s):  
Xiao-Nan Li ◽  
Zi-Wei Du ◽  
Qiang Huang
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Malignant Glioma ◽  
Culture Media ◽  
Morphological Changes ◽  
Control Group ◽  
Cell Cycle Distribution ◽  
Content Type ◽  
Hexamethylene Bisacetamide ◽  
Human Malignant Glioma

✓ The modulation effects of hexamethylene bisacetamide (HMBA), a differentiation-inducing agent, on growth and differentiation of cells from human malignant glioma cell line SHG-44 were studied. At cytostatic doses (2.5 mM, 5 mM, 7.5 mM, and 10 mM for 15 days), HMBA exerted a marked inhibitory effect on cell proliferation. Exposure to HMBA (5 mM and 10 mM for 12 days) also resulted in an accumulation of cells in G0/G1 phase and a decrease of cells in S phase as analyzed by flow cytometry. The reversible effects of 7.5 mM HMBA and 10 mM HMBA on cell proliferation and 10 mM HMBA on disruption of cell cycle distribution were observed when HMBA was removed from culture media on Day 6 and replaced with HMBA-free media. Colony-forming efficiency (CFE) in soft agar was remarkably decreased by HMBA (2.5 mM, 5 mM, 7.5 mM, and 10 mM for 14 days), and in 7.5 mM HMBA— and 10 mM HMBA—treated cells, the CFEs were reduced to 25% and 12.5%, respectively, of that in untreated cells. Cells treated with HMBA (5 mM and 10 mM for 15 days) remained tumorigenic in athymic nude mice, but the growth rates of the xenografts were much slower than those in the control group. The effects of HMBA on cell proliferation, cell cycle distribution, CFE, and growth of xenografts were dose dependent. A more mature phenotype was confirmed by the morphological changes from spindle shape to large polygonal stellate shape and remarkably elevated expression of glial fibrillary acidic protein in cells exposed to HMBA (5 mM, 10 mM for 15 days). Our results showed that a more differentiated phenotype with marked growth arrest was induced in SHG-44 cells by HMBA.

Human Malignant Glioma Cell Lines are Refractory to Retinoic Acid-Mediated Differentiation and Sensitization to Apoptosis1

2000 ◽  
Vol 10 (3) ◽  
pp. 159-168 ◽  
Author(s):  
Friederike Schmidt ◽  
Peter Groscurth ◽  
Johannes Dichgans ◽  
Michael Weller
Keyword(s):  
Retinoic Acid ◽  
Malignant Glioma ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cell Lines ◽  
Human Malignant Glioma

Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma

2013 ◽  
Vol 265 (1-2) ◽  
pp. 106-116 ◽  
Author(s):  
Katharina Ochs ◽  
Felix Sahm ◽  
Christiane A. Opitz ◽  
Tobias V. Lanz ◽  
Iris Oezen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Malignant Glioma ◽  
Human Malignant Glioma

scholarly journals Induction of senescence in human malignant glioma cells by p16INK4A

Oncogene ◽  
1997 ◽  
Vol 15 (5) ◽  
pp. 505-514 ◽  
Author(s):  
Lene Uhrbom ◽  
Monica Nistér ◽  
Bengt Westermark
Keyword(s):  
Malignant Glioma ◽  
Glioma Cells ◽  
Human Malignant Glioma ◽  
Malignant Glioma Cells
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