Prediction of drug oxidation rates in man: Lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6?-hydroxycortisol

1974 ◽  
Vol 7 (1) ◽  
pp. 71-75 ◽  
Author(s):  
S. E. Smith ◽  
M. D. Rawlins
Keyword(s):  
Urinary Excretion ◽  
Glucaric Acid ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Oxidation Rates ◽  
Drug Oxidation ◽  
Glutamyl Transpeptidase

Urinary D-glucaric Acid Excretion and Serum Gamma-glutamyl Transpeptidase Activity in Alcoholism

Addiction ◽  
1975 ◽  
Vol 70 (4) ◽  
pp. 359-364 ◽  
Author(s):  
J. Spencer-Peet ◽  
D. C. F. Wood ◽  
M. M. Glatt ◽  
S. M. Wiseman
Keyword(s):  
Acid Excretion ◽  
Glucaric Acid ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

scholarly journals Proteinuria following Trauma

1986 ◽  
Vol 23 (6) ◽  
pp. 681-685 ◽  
Author(s):  
Peter Gosling ◽  
Anne J Sutcliffe
Keyword(s):  
Urinary Excretion ◽  
Total Protein ◽  
Injury Severity ◽  
Trauma Patients ◽  
C Reactive Protein ◽  
Tubular Proteinuria ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Reactive Protein ◽  
Glutamyl Transpeptidase

Thirteen trauma patients admitted to a major injuries unit were classified according to their injury severity. Urinary excretion of total protein, albumin and gamma glutamyl transpeptidase (GGT) activity were assessed over the following 6 days. All patients showed an initial glomerular and tubular proteinuria during the first 24 h which subsided by the second post-trauma day. The excretion of total protein and albumin was positively correlated with injury severity. Those patients with the severest injuries showed a marked recurrent total proteinuria around days 3 to 4 post-trauma which exhibited features of a tubular lesion. The recurrent proteinuria peak coincided with peak levels of serum c-reactive protein (CRP).

Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

2018 ◽  
Vol 69 (3) ◽  
pp. 739-743 ◽  
Author(s):  
Madalina Irina Mitran ◽  
Ilinca Nicolae ◽  
Corina Daniela Ene ◽  
Cristina Iulia Mitran ◽  
Clara Matei ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lichen Planus ◽  
Inflammatory Process ◽  
Molecular Mechanisms ◽  
Functional Adaptation ◽  
Physical Factors ◽  
Inflammatory Disorder ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

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