Binding of thioridazine and thioridazine metabolites to serum proteins in psychiatric patients

1978 ◽  
Vol 14 (5) ◽  
pp. 341-350 ◽  
Author(s):  
G. Nyberg ◽  
R. Axelsson ◽  
E. M�rtensson
Keyword(s):  
Serum Proteins ◽  
Psychiatric Patients ◽  
Thioridazine Metabolites

Investigation of Precipitins to Human Brain in Sera of Psychotic Patients

1965 ◽  
Vol 111 (479) ◽  
pp. 1003-1006 ◽  
Author(s):  
Robert T. Rubin
Keyword(s):  
Human Brain ◽  
Complement Fixation ◽  
Serum Proteins ◽  
Psychiatric Patients ◽  
Double Diffusion ◽  
Brain Extract ◽  
Monkey Brain ◽  
Functional Psychoses ◽  
Schizophrenic Patients ◽  
Altered Serum

Altered serum proteins in mental illness have been reported by workers in various parts of the world, and a review of these studies has led to the consideration of an autoimmune mechanism in the pathogenesis of some functional psychoses (Fessel, 1962a). Several reports have appeared in recent years which suggest the presence of antibodies in the serum of certain psychiatric patients to central nervous system tissue. Many of these have been reviewed by Vartanyan (1963). Fessel (1962b, 1963) demonstrated agglutination of latex particles coated with monkey brain extract and agglutination of tanned sheep red blood cells coated with human brain extract, but no precipitins in double diffusion in agar of the sera against monkey brain extract. As an alternative to antibrain antibodies he suggested a less specific physicochemical abnormality of the serum which caused the agglutination. Yokoyama, Trams, and Brady (1962), using a sheep red blood cell haemagglutination technique, showed the presence of anti-asialoganglioside antibodies in the sera of 3 of 14 schizophrenic patients and anti-ganglioside antibody in the serum of another. Kuznetzova and Semenov (1961), by complement fixation, demonstrated antibodies in the sera of 22 of 84 schizophrenics, mainly to human brain and not to other organs. The antibodies appeared more frequently in the later stages of the illness (Semenov, Morozov, and Kuznetzova, 1961). Skalickova and Jezkova (1961), also with a complement fixation technique, demonstrated blood and cerebrospinal fluid antibodies to grey and white matter during the “infectious” onset of schizophrenia, but not in the chronic, demented phase.

Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

1977 ◽  
Vol 35 ◽  
pp. 498-499
Author(s):  
W.T. Collins ◽  
Charles C. Capen ◽  
Louis Kasza
Keyword(s):  
Feed Efficiency ◽  
Polychlorinated Biphenyl ◽  
Serum Proteins ◽  
Skin Lesions ◽  
Hepatic Necrosis ◽  
Ultrastructural Changes ◽  
Lymphoid Tissues ◽  
Heat Transfer Fluids ◽  
Thyroid Follicular Cells ◽  
Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

Massive distension of the esophageal stump after cervical esophagogastrostomy in psychiatric patients

2000 ◽  
Vol 13 (3) ◽  
pp. 248-250
Author(s):  
P. Yannopoulos ◽  
I. Katsoulis ◽  
G. Chatzikonstantinou ◽  
G. Veloudis
Keyword(s):  
Psychiatric Patients

Serum Proteins in Ulcerative Colitis

1959 ◽  
Vol 37 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Richard O. Bicks ◽  
Joseph B. Kirsner ◽  
Walter L. Palmer
Keyword(s):  
Ulcerative Colitis ◽  
Serum Proteins

Reliability of Measured Interests of Hospitalized Psychiatric Patients

1968 ◽  
Vol 1 (2) ◽  
pp. 115-121
Author(s):  
Dennis W. Olson ◽  
Richard W. Johnson
Keyword(s):  
Psychiatric Patients

Too Much to Bear

Crisis ◽  
2016 ◽  
Vol 37 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Nicole J. Peak ◽  
James C. Overholser ◽  
Josephine Ridley ◽  
Abby Braden ◽  
Lauren Fisher ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Concurrent Validity ◽  
Medical Center ◽  
Psychiatric Patients ◽  
Preliminary Evidence ◽  
Diagnostic Interview ◽  
Veterans Affairs ◽  
Self Report ◽  
Perceived Burdensomeness ◽  
Scale Method

Abstract. Background: People who feel they have become a burden on others may become susceptible to suicidal ideation. When people no longer feel capable or productive, they may assume that friends and family members would be better off without them. Aim: The present study was designed to assess preliminary psychometric properties of a new measure, the Perceived Burdensomeness (PBS) Scale. Method: Depressed psychiatric patients (N = 173) were recruited from a veterans affairs medical center. Patients were assessed with a structured diagnostic interview and self-report measures assessing perceived burdensomeness, depression severity, hopelessness, and suicidal ideation. Results: The present study supported preliminary evidence of reliability and concurrent validity of the PBS. Additionally, perceived burdensomeness was significantly associated with higher levels of hopelessness and suicidal ideation. Conclusion: It is hoped that with the aid of the PBS clinicians may be able to intervene more specifically in the treatment of suicidality.

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