Parametric imaging of the rate constant Ki using [18Fluoro]-l-dopa positron emission tomography in progressive supranuclear palsy

1993 ◽  
Vol 35 (6) ◽  
pp. 404-409 ◽  
Author(s):  
M. Cordes ◽  
B. J. Snow ◽  
S. Morrison ◽  
V. Sossi ◽  
T. J. Ruth ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Progressive Supranuclear Palsy ◽  
Rate Constant ◽  
Emission Tomography ◽  
Parametric Imaging ◽  
Positron Emission

scholarly journals Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain

2003 ◽  
Vol 23 (9) ◽  
pp. 1096-1112 ◽  
Author(s):  
Masanori Ichise ◽  
Jeih-San Liow ◽  
Jian-Qiang Lu ◽  
Akihiro Takano ◽  
Kendra Model ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Binding Potential ◽  
Parametric Imaging ◽  
Reference Tissue ◽  
Parametric Images ◽  
Positron Emission ◽  
Tissue Models

The authors developed and applied two new linearized reference tissue models for parametric images of binding potential ( BP) and relative delivery ( R1) for [11C]DASB positron emission tomography imaging of serotonin transporters in human brain. The original multilinear reference tissue model (MRTMO) was modified (MRTM) and used to estimate a clearance rate ( k′2) from the cerebellum (reference). Then, the number of parameters was reduced from three (MRTM) to two (MRTM2) by fixing k′2. The resulting BP and R1 estimates were compared with the corresponding nonlinear reference tissue models, SRTM and SRTM2, and one-tissue kinetic analysis (1TKA), for simulated and actual [11C]DASB data. MRTM gave k′2 estimates with little bias (<1%) and small variability (<6%). MRTM2 was effectively identical to SRTM2 and 1TKA, reducing BP bias markedly over MRTMO from 12–70% to 1–4% at the expense of somewhat increased variability. MRTM2 substantially reduced BP variability by a factor of two or three over MRTM or SRTM. MRTM2, SRTM2, and 1TKA had R1 bias <0.3% and variability at least a factor of two lower than MRTM or SRTM. MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies.

scholarly journals 18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study

2017 ◽  
Vol 82 (4) ◽  
pp. 622-634 ◽  
Author(s):  
Daniel R. Schonhaut ◽  
Corey T. McMillan ◽  
Salvatore Spina ◽  
Bradford C. Dickerson ◽  
Andrew Siderowf ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Parkinson Disease ◽  
Progressive Supranuclear Palsy ◽  
Multicenter Study ◽  
Emission Tomography ◽  
Positron Emission

Positron Emission Tomography in Progressive Supranuclear Palsy

1991 ◽  
Vol 48 (4) ◽  
pp. 389-391 ◽  
Author(s):  
M. H. Bhatt ◽  
B. J. Snow ◽  
W. R. W. Martin ◽  
R. Peppard ◽  
D. B. Calne
Keyword(s):  
Positron Emission Tomography ◽  
Progressive Supranuclear Palsy ◽  
Emission Tomography ◽  
Positron Emission

Measured dose rate constant from oncology patients administered 18F for positron emission tomography

2012 ◽  
Vol 39 (10) ◽  
pp. 6071-6079 ◽  
Author(s):  
Brian Quinn ◽  
Brian Holahan ◽  
Jean Aime ◽  
John Humm ◽  
Jean St. Germain ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dose Rate ◽  
Rate Constant ◽  
Emission Tomography ◽  
Oncology Patients ◽  
Positron Emission ◽  
Measured Dose

P2-156: Tau positron emission tomography images with a novel tracer, 18F-THK5351, in a patient with progressive supranuclear palsy

2015 ◽  
Vol 11 (7S_Part_12) ◽  
pp. P547-P547
Author(s):  
Aiko Ishiki ◽  
Ryuichi Harada ◽  
Naoki Tomita ◽  
Nobuyuki Okamura ◽  
Katsutoshi Furukawa ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Progressive Supranuclear Palsy ◽  
Emission Tomography ◽  
Positron Emission
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