Steroid glycosides of the roots ofCapsicum annuum. II. The structure of the capsicosides

1987 ◽  
Vol 23 (2) ◽  
pp. 202-205 ◽  
Author(s):  
E. V. Gutsu ◽  
P. K. Kintya ◽  
G. V. Lazur'evskii
Keyword(s):  
Steroid Glycosides

scholarly journals Steroid Glycosides Hyrcanoside and Deglucohyrcanoside: On Isolation, Structural Identification, and Anticancer Activity

Foods ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 136
Author(s):  
Silvie Rimpelová ◽  
Tomáš Zimmermann ◽  
Pavel B. Drašar ◽  
Bohumil Dolenský ◽  
Jiří Bejček ◽  
...  
Keyword(s):  
Drug Repositioning ◽  
Biological Activities ◽  
Cancer Therapeutics ◽  
Structural Identification ◽  
Induce Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Steroid Glycosides ◽  
In Silico Modeling ◽  
M Phase ◽  
Atpase Inhibition

Cardiac glycosides (CGs) represent a group of sundry compounds of natural origin. Most CGs are potent inhibitors of Na+/K+-ATPase, and some are routinely utilized in the treatment of various cardiac conditions. Biological activities of other lesser known CGs have not been fully explored yet. Interestingly, the anticancer potential of some CGs was revealed and thereby, some of these compounds are now being evaluated for drug repositioning. However, high systemic toxicity and low cancer cell selectivity of the clinically used CGs have severely limited their utilization in cancer treatment so far. Therefore, in this study, we have focused on two poorly described CGs: hyrcanoside and deglucohyrcanoside. We elaborated on their isolation, structural identification, and cytotoxicity evaluation in a panel of cancerous and noncancerous cell lines, and on their potential to induce cell cycle arrest in the G2/M phase. The activity of hyrcanoside and deglucohyrcanoside was compared to three other CGs: ouabain, digitoxin, and cymarin. Furthermore, by in silico modeling, interaction of these CGs with Na+/K+-ATPase was also studied. Hopefully, these compounds could serve not only as a research tool for Na+/K+-ATPase inhibition, but also as novel cancer therapeutics.

Steroid glycosides ofNicotiana tabacum seeds I. The structures of nicotianosides A, B, and E

1994 ◽  
Vol 30 (6) ◽  
pp. 684-688 ◽  
Author(s):  
S. A. Shvets ◽  
P. K. Kintya ◽  
O. N. Gutsu
Keyword(s):  
Ofnicotiana Tabacum ◽  
Steroid Glycosides

scholarly journals Zebrafish Bioassay-Guided Microfractionation Identifies Anticonvulsant Steroid Glycosides from the Philippine Medicinal PlantSolanum torvum

2014 ◽  
Vol 5 (10) ◽  
pp. 993-1004 ◽  
Author(s):  
Soura Challal ◽  
Olivia E. M. Buenafe ◽  
Emerson F. Queiroz ◽  
Snezana Maljevic ◽  
Laurence Marcourt ◽  
...  
Keyword(s):  
Steroid Glycosides

scholarly journals UJI AKTIVITAS ANTIOKSIDAN EKSTRAK KARANG LUNAK Klyxum Sp YANG DIKOLEKSI DARI DESA TUMBAK KECAMATAN POSUMAEN MINAHASA TENGGARA

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 205
Author(s):  
Elur Lonteng ◽  
Adithya Yudistira ◽  
Defny S Wewengkang
Keyword(s):  
Antioxidant Activity ◽  
Bioactive Compounds ◽  
Soft Coral ◽  
Health Sector ◽  
Antioxidant Compounds ◽  
Steroid Glycosides ◽  
Concentration Test ◽  
Ethanol Extracts

ABSTRACT Soft Coral Klyxum sp.. is a rich sources in bioactive compounds such as terpenoids, steroids, and steroid glycosides which are commonly used in the health sector. The purpose of this study was to determine the activity of antioxidant compounds from ethanol extracts of Klyxum sp. Klyxum sp., was extracted by maceration using ethanol as a solvent. As a parameter, testing of antioxidant activity was carried out using the DPPH (1,1-diphenil-2-picrylhydarzyl) method, which was measured using UV-Vis spectrophotometry at a wavelength of 517 nm. The results showed that the ethanol extracts of soft coral  Klyxum sp., proven to have antioxidant activity in each concentration test. Keywords: Klyxum sp. Soft Coral, Antioxidants, Extraction, DPPH   ABSTRAK Karang Lunak Klyxum sp. merupakan sumber yang kaya akan senyawa bioaktif seperti terpenoid, steroid, dan steroid glikosida yang biasa dimanfaatkan dalam dibidang kesehatan. Tujuan dari penelitian ini yaitu, untuk mengetahui aktivitas senyawa antioksidan dari ekstrak etanol Karang Lunak Klyxum sp. Karang Lunak Klyxum sp. diekstraksi menggunakan metode maserasi dengan etanol sebagai pelarut. Sebagai parameter, pengujian aktivitas antioksidan dilakukan dengan metode DPPH (1,1-diphenil-2-picrylhydarzyl) yang diukur menggunakan Spektrofotometri UV-Vis pada panjang gelombang 517 nm. Hasil penelitian menunjukkan ekstrak etanol Karang Lunak Klyxum sp. terbukti memiliki aktivitas antioksidan disetiap konsentrasi pengujian. Kata Kunci : Karang Lunak Klyxum sp., Antioksidan, Ekstraksi, DPPH

Steroid glycosides from Solanum tuberosum seeds tuberosides C and D

1991 ◽  
Vol 27 (4) ◽  
pp. 515-516
Author(s):  
P. K. Kintya ◽  
T. I. Prasol
Keyword(s):  
Solanum Tuberosum ◽  
Steroid Glycosides

scholarly journals New Neuritogenic Steroid Glycosides from the Vietnamese Starfish Linckia Laevigata

2007 ◽  
Vol 2 (1) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Alla A. Kicha ◽  
Natalia V. Ivanchina ◽  
Anatoly I. Kalinovsky ◽  
Pavel S. Dmitrenok ◽  
Natalia V. Palyanova ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Chemical Transformations ◽  
Steroid Glycosides ◽  
New Compounds ◽  
Neuritogenic Activity ◽  
Linckia Laevigata

Two new steroid glycosides, linckosides L1 (1) and L2 (2), were isolated, along with the previously known echinasteroside C (3) from the ethanolic extract of the Vietnamese blue starfish, Linckia laevigata. The structures of the new compounds were elucidated by spectroscopic methods (mainly 2D NMR) and chemical transformations. Lifetime observations and analyses of silver impregnated preparations on the culture of neuroblastoma C-1300 cells showed that glycosides 1, 2, and 3 are capable of inducing neuronal differentiation similar to that of neurotrophins and of enhancing substantially the neuritogenic activity of NGF.

Four new steroid glycosides from the Vietnamese starfish Linckia laevigata

2007 ◽  
Vol 56 (4) ◽  
pp. 823-830 ◽  
Author(s):  
A. A. Kicha ◽  
N. V. Ivanchina ◽  
A. I. Kalinovsky ◽  
P. S. Dmitrenok ◽  
E. V. Sokolova ◽  
...  
Keyword(s):  
Steroid Glycosides ◽  
Linckia Laevigata
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