Asymmetrical displacement current and its relation with the activation of sodium current in the membrane of frog myelinated nerve

1976 ◽  
Vol 363 (3) ◽  
pp. 193-203 ◽  
Author(s):  
B. Neumcke ◽  
W. Nonner ◽  
R. St�mpfli
Keyword(s):  
Sodium Current ◽  
Displacement Current ◽  
Myelinated Nerve ◽  
Asymmetrical Displacement

Block of sodium current in myelinated nerve fibre with enkephalins

1982 ◽  
Vol 21 (7) ◽  
pp. 619-623 ◽  
Author(s):  
M.R. Carratù ◽  
J.M. Dubois ◽  
D. Mitolo-Chieppa
Keyword(s):  
Nerve Fibre ◽  
Sodium Current ◽  
Myelinated Nerve Fibre ◽  
Myelinated Nerve

Ionic currents in vertebrate myelinated nerve at hyperbaric pressure

1984 ◽  
Vol 246 (1) ◽  
pp. C84-C90 ◽  
Author(s):  
J. J. Kendig
Keyword(s):  
Steady State ◽  
Sodium Current ◽  
Ionic Currents ◽  
Base Line ◽  
Myelinated Nerve ◽  
Hyperbaric Pressure ◽  
Voltage Curve ◽  
Current Voltage ◽  
Voltage Dependent ◽  
Steady State Inactivation

To establish a base line for a study of anesthetic-pressure antagonism in axons, voltage-clamped nodes of Ranvier from amphibian sciatic nerve were subjected to pressures of 1-100 atm. Over the time of compression, there was usually an irreversible decrease in peak inward sodium current, but there was no change in peak outward sodium current or in the current-voltage relationship. The steady-state inactivation-voltage curve was shifted 5-15 mV in the depolarizing direction at 70-100 atm. The rate of rise of the sodium current was slowed, as was the time constant of inactivation (tau h). Increase in tau h was markedly voltage dependent, suggesting a selective effect of pressure on beta h, the rate constant governing development of the inactive state. The rate of development of steady-state outward potassium current was also decreased, without significant change in maximum current. The effects of pressure are qualitatively similar to, but different in detail from, those reported in squid axon and different in some details from the effects of cooling in this preparation. None of the effects can presently be related to the high-pressure nervous syndrome.

Sodium current in human small intestinal interstitial cells of cajal

2001 ◽  
Vol 120 (5) ◽  
pp. A201-A201 ◽  
Author(s):  
P STREGE ◽  
A RICH ◽  
Y OU ◽  
S GIBBONS ◽  
M SARR ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Sodium Current ◽  
Interstitial Cells ◽  
Small Intestinal ◽  
Cells Of Cajal
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