A study on cell lineage, especially the germ cell line, in embryos of the teleost fish,Barbus conchonius

1992 ◽  
Vol 201 (5) ◽  
pp. 275-283 ◽  
Author(s):  
Petra Gevers ◽  
John Dulos ◽  
Jos G. M. Boogaart ◽  
Lucy P. M. Timmermans
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Teleost Fish ◽  
Cell Lineage ◽  
Germ Cell Line

Effect of kinase-negativeEGFR gene on differentiation of embryonic germ cell line EG4

2001 ◽  
Vol 46 (16) ◽  
pp. 1364-1366 ◽  
Author(s):  
Xin Xu ◽  
Xiaoqian Cong ◽  
Shangquan Zhang ◽  
Yuanchang Yan
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Germ Cell Line

scholarly journals Erythropoietin production by a human testicular germ cell line

Blood ◽  
1983 ◽  
Vol 62 (5) ◽  
pp. 1132-1134 ◽  
Author(s):  
JL Ascensao ◽  
F Gaylis ◽  
D Bronson ◽  
EE Fraley ◽  
ED Zanjani
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Continuous Cell Line ◽  
Human Testis ◽  
Testicular Germ Cell ◽  
Germ Cell Line ◽  
Erythropoietin Production ◽  
Unique Model

Abstract An established human testis germ cell line (1411-H) was found to produce significant amounts of erythropoietin (Ep), the primary regulator of erythropoiesis. Media conditioned by the 1411-H cells stimulated erythropoiesis both in vivo and in vitro. This activity was neutralized by anti-Ep. This continuous cell line provides a unique model for the study of the mechanisms of control of Ep biogenesis.

scholarly journals Estrogen Receptor β-Mediated Inhibition of Male Germ Cell Line Development in Mice by Endogenous Estrogens during Perinatal Life

Endocrinology ◽  
2004 ◽  
Vol 145 (7) ◽  
pp. 3395-3403 ◽  
Author(s):  
Géraldine Delbès ◽  
Christine Levacher ◽  
Catherine Pairault ◽  
Chrystèle Racine ◽  
Clotilde Duquenne ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Germ Cell ◽  
Experimental Studies ◽  
Cell Lineage ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Testicular Development ◽  
Fetal Life ◽  
Germ Cell Line ◽  
Highly Sensitive ◽  
Labeling Method

Abstract Epidemiological, clinical, and experimental studies have suggested that excessive exposure to estrogens during fetal/neonatal life can lead to reproductive disorders and sperm abnormalities in adulthood. However, it is unknown whether endogenous concentrations of estrogens affect the establishment of the male fetal germ cell lineage. We addressed this question by studying the testicular development of mice in which the estrogen receptor (ER) β or the ERα gene was inactivated. The homozygous inactivation of ERβ (ERβ−/−) increased the number of gonocytes by 50% in 2- and 6-d-old neonates. The numbers of Sertoli and Leydig cells and the level of testicular testosterone production were unaffected, suggesting that estrogens act directly on the gonocytes. The increase in the number of gonocytes did not occur during fetal life but instead occurred just after birth, when gonocytes resumed mitosis and apoptosis. It seems to result from a decrease in the apoptosis rate evaluated by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and cleaved caspase-3 immunohistochemical detection. Last, mice heterozygous for the ERβ gene inactivation behaved similarly to their ERβ−/− littermates in terms of the number of gonocytes, apoptosis, and mitosis, suggesting that these cells are highly sensitive to the binding of estrogens to ERβ. ERα inactivation had no effect on the number of neonatal gonocytes and Sertoli cells. In conclusion, this study provides the first demonstration that endogenous estrogens can physiologically inhibit germ cell growth in the male. This finding may have important implications concerning the potential action of environmental estrogens.

A trisomic germ cell line and precocious chromatid segregation leads to recurrent trisomy 21 conception

1999 ◽  
Vol 104 (1) ◽  
pp. 23-28 ◽  
Author(s):  
J. Cozzi ◽  
Clare M. Conn ◽  
Joyce Harper ◽  
Robert M. L. Winston ◽  
M. Rindl ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Trisomy 21 ◽  
Germ Cell Line ◽  
Chromatid Segregation

Direct evidence that the mouse sex-determining geneSry is expressed in the somatic cells of male fetal gonads and in the germ cell line in the adult testis

1993 ◽  
Vol 34 (4) ◽  
pp. 369-373 ◽  
Author(s):  
Pellegrino Rossi ◽  
Susanna Dolci ◽  
Cristina Albanesi ◽  
Paola Grimaldi ◽  
Raffaele Geremia
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Direct Evidence ◽  
Somatic Cells ◽  
Adult Testis ◽  
Germ Cell Line

60,XY/60,XX chimerism in the germ cell line of mature bulls born in heterosexual twinning

2000 ◽  
Vol 54 (4) ◽  
pp. 621-627 ◽  
Author(s):  
B. Rejduch ◽  
E. Słota ◽  
I. Gustavsson
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Germ Cell Line

Sox3 Affects Kit Expression in a Differentiated Germ Cell Line.

2010 ◽  
Vol 83 (Suppl_1) ◽  
pp. 68-68
Author(s):  
Monica M. Laronda ◽  
J. Larry Jameson
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Germ Cell Line
Sign in / Sign up

Export Citation Format

Share Document