Endoscopic fistulotomy and biliary drainage as the ultimate palliative treatment for obstruction due to malignant tumors of the papilla of Vater

1990 ◽  
Vol 4 (2) ◽  
pp. 88-90 ◽  
Author(s):  
C. Feretis ◽  
D. Tabakopoulos ◽  
P. Benakis ◽  
M. Xenofontos ◽  
B. Golematis
Suizo ◽  
2006 ◽  
Vol 21 (4) ◽  
pp. 353-357 ◽  
Author(s):  
Kenji YAMAO ◽  
Nobumasa MIZUNO ◽  
Kuniyuki TAKAHASHI ◽  
Akira SAWAKI ◽  
Hiroyuki INOUE ◽  
...  

1998 ◽  
Vol 118 (4) ◽  
pp. 496-503 ◽  
Author(s):  
A. Howard Burris ◽  
Charles L. Vogel ◽  
Dan Castro ◽  
Lopa Mishra ◽  
Maurice Schwarz ◽  
...  

Intratumoral injections of cisplatin/epinephrine-injectable gel were administered weekly for 4 weeks in 45 patients with malignant tumors of various histologic types. Tumors were located on the skin and subcutaneous tissue primarily of the head, neck, and trunk, and on the tongue, oral pharynx, and esophagus. Patients were not candidates for surgery, radiation, or systemic chemotherapy. Each of the treated tumors ( n = 82) was evaluated 2, 4, 8, and 12 weeks after the final injection. The initial dose of cisplatin was 1 mg/cm3 tumor volume, with escalation to 6 mg/cm3 allowed, depending on observed toxicities. The mean cumulative dose per patient for the four treatments ranged from 0.56 to 380 mg cisplatin. No dose-limiting cisplatin-related toxicities, such as nephrotoxicity, neurotoxicity, or ototoxicity, were observed. The overall objective tumor response rate was 50% (41 of 82), with 40% (33 of 82) complete responses and a median response duration of 160 days. Complete responses for adenocarcinoma and squamous cell carcinoma were 58% (21 of 36) and 38% (12 of 32), respectively. These results justified further clinical trials to evaluate the role of local chemotherapy with intratumoral cisplatin/epinephrine-injectable gel in the palliative treatment of patients with selected accessible solid tumors.


1995 ◽  
Vol 2 (2) ◽  
pp. 79-87 ◽  
Author(s):  
Jose Pablo Diaz-Jimenez ◽  
Jose Ignacio Martinez Ballarin ◽  
Eva Farrero Muñoz ◽  
Kevin L. Kovitz ◽  
Maria Jesus Castro Serrano ◽  
...  

Between 1984 and 1993 we performed 2105 laser treatments in 1210 patients: 52% of treatments were done for malignant pathology, 45% for benign tracheal stenoses and 3% were in a miscellaneous group. The procedure was carried out with a rigid bronchoscope under general anaesthesia. In patients with malignant tumors, it is a good palliative treatment—safe, well tolerated and with immediate results; it can be repeated as many times as needed with and is well accepted by the patient. In patients without tumors, this method avoids emergency tracheotomies. The long term results are now under evaluation.


1999 ◽  
Vol 229 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Hans J. Schlitt ◽  
Arved Weimann ◽  
Jürgen Klempnauer ◽  
Karl J. Oldhafer ◽  
Björn Nashan ◽  
...  

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 456-456
Author(s):  
Ana Wilson ◽  
Cecilia Grace Ethun ◽  
George A. Poultsides ◽  
Thuy Tran ◽  
Kamran Idrees ◽  
...  

456 Background: Extrahepatic biliary malignancies (EBM) are often first diagnosed at advanced stages when the disease is no longer surgically resectable. While palliative resection may provide a more definitive solution for patients with jaundice, it also carries a higher risk of complications than endoscopic or percutaneous drainage. Herein, we analysed patients undergoing both methods of palliation to better delineate these risks. Methods: 172 patients who underwent palliative treatment for EBM between 2000 and 2014 were identified from 10 major hepato-biliary centers participating in the EBM Consortium. Clinicopathologic, operative and outcome data were collected and analyzed. We used propensity score matching to correct for confounding by indication. Results: 113 patients underwent surgery with palliative resection of their tumor (65.7%), while 59 underwent diagnostic surgery, but were treated with percutaneous or endoscopic biliary drainage instead of resection (34.3%). Patients who were not resected were more frequently jaundiced preoperatively (p = 0.001), and were more likely to undergo repeat drainage procedures (p < 0.001). After matching for functional status, age, and clinical jaundice, patients who underwent resection had significantly more complications (55.6% vs. 34.0%; p = 0.035), a higher median number of complications (1 vs. 0; p = 0.0149), a higher Clavien Dindo Grade (IIIa vs. II; p = 0.0261), a longer hospital stay (8 vs. 4 days; p < 0.001), and a notable trend towards higher perioperative mortality (10.9% vs. 1.96%; p = 0.069). Meanwhile the postoperative bilirubin level was equal among the resected (1.80 mg/dL (IQR, 0.60-8.90)) and drainage groups (2.45 (IQR 0.60-10.5))(p = 0.477), and both groups had a statistically significant drop after treatment (resection 8.30 mg/dL to 1.80 mg/dL, p < 0.001; drainage 8.4 to 2.45, p < 0.001). Conclusions: Both palliative resection and biliary drainage successfully treated EBM patients’ hyperbilirubinemia. However, in a propensity score matched group, palliative resection patients had more complications and a trend towards more perioperative mortality, urging caution in the selection of patients for these procedures.


2010 ◽  
Vol 48 (05) ◽  
Author(s):  
M Varsányi ◽  
L Szentpéteri ◽  
P Vukov ◽  
E Gaálné ◽  
S Kecskésné ◽  
...  

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