scholarly journals Role of the macula densa in the control of renal renin gene expression in two-kidney/one-clip rats

1994 ◽  
Vol 427 (1-2) ◽  
pp. 42-46 ◽  
Author(s):  
Karin Schricker ◽  
Marlies Hamann ◽  
Brigitte Kaissling ◽  
Armin Kurtz
Keyword(s):  
Gene Expression ◽  
Macula Densa ◽  
Renin Gene

The role of angiotensin II in the feedback control of renin gene expression

1997 ◽  
Vol 434 (2) ◽  
pp. 166-172 ◽  
Author(s):  
Karin Schricker ◽  
Stephan Holmer ◽  
Bernhard K. Krämer ◽  
Günter A. J. Riegger ◽  
A. Kurtz
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Feedback Control ◽  
Renin Gene

Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life

1992 ◽  
Vol 262 (3) ◽  
pp. R459-R463 ◽  
Author(s):  
W. V. Page ◽  
S. Perlman ◽  
F. G. Smith ◽  
J. L. Segar ◽  
J. E. Robillard
Keyword(s):  
Gene Expression ◽  
Plasma Renin ◽  
Renal Nerves ◽  
Mrna Levels ◽  
Angiotensin I ◽  
Fetal Sheep ◽  
Close Analysis ◽  
Renin Gene ◽  
Renin Mrna

The role of renal nerves in regulating changes in plasma renin activity (PRA) and renal renin gene expression was studied in intact (n = 6) and denervated (n = 6) fetal sheep before birth and during the first 24 h after delivery. Renal denervation completely blunted the rise in PRA observed 24 h after delivery in newborn lambs; in lambs with intact kidneys, PRA increased significantly (P less than 0.05) from 3.26 +/- 0.60 (predelivery) to 6.34 +/- 1.85 ng angiotensin I (ANG I).ml-1.h-1 (24 h postdelivery), while in lambs with denervated kidneys, predelivery and post-delivery values were 2.84 +/- 0.19 and 2.49 +/- 0.45 ng ANG I.ml-1.h-1, respectively. Renin mRNA levels were significantly lower (P less than 0.001) in denervated than in intact kidneys 24 h after birth. A close analysis of these results also revealed that renin mRNA levels were significantly higher (P less than 0.001) in intact kidneys of newborn lambs delivered vaginally (n = 3) than in newborn lambs delivered by cesarean section (n = 3). These results suggest that renal nerves play an important role in regulating renin gene expression and PRA during the transition from fetal to newborn life.

Role of Endothelins for the Regulation of Renal Renin Gene Expression

2000 ◽  
Vol 36 (Supplement 1) ◽  
pp. S187-S190 ◽  
Author(s):  
Frank Schweda ◽  
Annette Schweda ◽  
Michael Pfeifer ◽  
Friedrich C. Blumberg ◽  
Martin C. Kammerl ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renin Gene

scholarly journals Role of CREB1 and NFκB-p65 in the Down-regulation of Renin Gene Expression by Tumor Necrosis Factor α

2005 ◽  
Vol 280 (26) ◽  
pp. 24356-24362 ◽  
Author(s):  
Vladimir T. Todorov ◽  
Simon Völkl ◽  
Jürgen Friedrich ◽  
Leoni A. Kunz-Schughart ◽  
Thomas Hehlgans ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Down Regulation ◽  
Renin Gene ◽  
Factor Α ◽  
Necrosis Factor

Role of Endothelins for the Regulation of Renal Renin Gene Expression

2000 ◽  
Vol 36 ◽  
pp. S187-S190
Author(s):  
Frank Schweda ◽  
Annette Schweda ◽  
Michael Pfeifer ◽  
Friedrich C. Blumberg ◽  
Martin C. Kammerl ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renin Gene

Role of small nuclear RNAs in eukaryotic gene expression

2013 ◽  
Vol 54 ◽  
pp. 79-90 ◽  
Author(s):  
Saba Valadkhan ◽  
Lalith S. Gunawardane
Keyword(s):  
Gene Expression ◽  
Protein Interactions ◽  
Rna Stability ◽  
Splice Sites ◽  
Branch Site ◽  
Small Nuclear Rnas ◽  
Eukaryotic Gene Expression ◽  
Eukaryotic Gene ◽  
Rna Biogenesis

Eukaryotic cells contain small, highly abundant, nuclear-localized non-coding RNAs [snRNAs (small nuclear RNAs)] which play important roles in splicing of introns from primary genomic transcripts. Through a combination of RNA–RNA and RNA–protein interactions, two of the snRNPs, U1 and U2, recognize the splice sites and the branch site of introns. A complex remodelling of RNA–RNA and protein-based interactions follows, resulting in the assembly of catalytically competent spliceosomes, in which the snRNAs and their bound proteins play central roles. This process involves formation of extensive base-pairing interactions between U2 and U6, U6 and the 5′ splice site, and U5 and the exonic sequences immediately adjacent to the 5′ and 3′ splice sites. Thus RNA–RNA interactions involving U2, U5 and U6 help position the reacting groups of the first and second steps of splicing. In addition, U6 is also thought to participate in formation of the spliceosomal active site. Furthermore, emerging evidence suggests additional roles for snRNAs in regulation of various aspects of RNA biogenesis, from transcription to polyadenylation and RNA stability. These snRNP-mediated regulatory roles probably serve to ensure the co-ordination of the different processes involved in biogenesis of RNAs and point to the central importance of snRNAs in eukaryotic gene expression.

Induction of renal kallikrein and renin gene expression by insulin and IGF-I in the diabetic rat

Diabetes ◽  
1997 ◽  
Vol 46 (12) ◽  
pp. 2049-2056 ◽  
Author(s):  
A. A. Jaffa ◽  
C. Vio ◽  
V. Velarde ◽  
D. LeRoith ◽  
R. K. Mayfield
Keyword(s):  
Gene Expression ◽  
Diabetic Rat ◽  
Renin Gene ◽  
Igf I ◽  
Renal Kallikrein

Cell-specific regulation of IRS-1 gene expression: role of E box and C/EBP binding site in HepG2 cells and CHO cells

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 354-362 ◽  
Author(s):  
K. Matsuda ◽  
E. Araki ◽  
R. Yoshimura ◽  
K. Tsuruzoe ◽  
N. Furukawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Binding Site ◽  
Cho Cells ◽  
Hepg2 Cells ◽  
E Box ◽  
Specific Regulation
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