Voltage-dependent properties of macroscopic and elementary calcium channel currents in guinea pig ventricular myocytes

1986 ◽  
Vol 406 (5) ◽  
pp. 437-448 ◽  
Author(s):  
Terence F. McDonald ◽  
Adolfo Cavali� ◽  
Wolfgang Trautwein ◽  
Dieter Pelzer
Keyword(s):  
Guinea Pig ◽  
Calcium Channel ◽  
Ventricular Myocytes ◽  
Voltage Dependent ◽  
Channel Currents

Effects of ropivacaine on membrane potential and voltage-dependent calcium channel current in single guinea-pig ventricular myocytes

2002 ◽  
Vol 16 (4) ◽  
pp. 273-278 ◽  
Author(s):  
Noboru Hatakeyama ◽  
Masana Yamada ◽  
Nobuko Shibuya ◽  
Mitsuaki Yamazaki ◽  
Shigeo Yamamura ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Guinea Pig ◽  
Calcium Channel ◽  
Ventricular Myocytes ◽  
Channel Current ◽  
Voltage Dependent Calcium Channel ◽  
Voltage Dependent

Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells

1987 ◽  
Vol 253 (1) ◽  
pp. H210-H214
Author(s):  
M. Horie ◽  
H. Irisawa
Keyword(s):  
Guinea Pig ◽  
Action Potentials ◽  
Single Channel ◽  
Outward Current ◽  
Atrial Cells ◽  
Voltage Dependent ◽  
K Current ◽  
Single Channel Currents ◽  
Channel Currents ◽  
Low K

Rectifying properties of the acetylcholine (ACh)-sensitive K+ channels were studied using a patch-clamp method in single atrial cells prepared enzymatically from adult guinea pig hearts. In the presence of micromolar concentration of nonhydrolyzable guanosine 5'-triphosphate (GTP) analogue 5'-guanylylimidodiphosphate (GppNHp) and the absence of Mg2+ at the inner surface of patch membrane [( Mg2+]i), the channel activity recovered in inside-out patch condition. The single channel conductance became ohmic between -80 and +80 mV (symmetrical 150 mM K+ solutions). The rapid relaxation of outward single channel currents was disclosed on a depolarization. [Mg2+]i blocked the outward current through the channel dose- and voltage-dependently and also induced a dose-dependent increase in the channel activation. The apparent paradoxical role of [Mg2+]i is important for the cholinergic control in the heart; voltage-dependent Mg block ensures a low K+ conductance of cell membrane at the plateau of action potentials during the exposure to ACh, thereby slowing the heart rate without unfavorable shortening of the action potentials.

scholarly journals Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes

2007 ◽  
Vol 151 (8) ◽  
pp. 1198-1203 ◽  
Author(s):  
K Yazawa ◽  
J-W Wang ◽  
L-Y Hao ◽  
Y Onoue ◽  
M Kameyama
Keyword(s):  
Guinea Pig ◽  
Calcium Channel ◽  
Ventricular Myocytes ◽  
Channel Activity
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