The effect of a new vitamin D analog, 22-oxa-1?,25(OH)2D3, on bone mineral metabolism in normal male rats

1992 ◽  
Vol 50 (6) ◽  
pp. 521-523 ◽  
Author(s):  
Makoto Takizawa ◽  
Michael Fallon ◽  
Barry Stein ◽  
Sol Epstein
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Male Rats ◽  
Normal Male ◽  
Bone Mineral Metabolism ◽  
Vitamin D Analog

Impact of vitamin D supplementation on markers of bone mineral metabolism in term infants

Bone ◽  
2012 ◽  
Vol 51 (4) ◽  
pp. 781-786 ◽  
Author(s):  
Justyna Czech‐Kowalska ◽  
Pawel Pludowski ◽  
Anna Dobrzanska ◽  
Edyta Kryskiewicz ◽  
Elzbieta Karczmarewicz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Vitamin D Supplementation ◽  
Term Infants ◽  
Bone Mineral Metabolism

Abstract P389: Effects of Dietary Patterns on Vitamin D and Other Markers of Bone-Mineral Metabolism: Results From the Dash Trial

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Ahmed Hassoon ◽  
Lawrence Appel ◽  
Edgar Miller
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Control Diet ◽  
Urinary Calcium ◽  
Blood Levels ◽  
Dash Diet ◽  
Bone Mineral Metabolism ◽  
Vitamin D Levels ◽  
Total Fat

Background: The relationship of CVD with vitamin D levels and other markers of bone-mineral metabolism is of substantial interest. The Dietary Approaches to Stop Hypertension (DASH) diet effectively lowers blood pressure and is now recommended to promote CV health. The effects of the DASH diet on vitamin D and other markers of bone-mineral metabolism is unknown. Objective: To determine the effect of dietary patterns on blood levels of vitamin D, PTH, and ionized calcium, and urinary excretion of calcium and phosphate. Methods: Data on study outcomes were available in 334 participants from the original DASH trial. Baseline levels were obtained from blood and urine collected at the end of the run-in while on the control diet. Participants were then randomized to control diet (37% kcal total fat); fruits & vegetable diet (also 37% kcal total fat); or the DASH diet (27% kcal total fat). Follow-up levels were obtained during the last week of the eight-week intervention period. Results: Mean (±SD) baseline blood levels of vitamin D, PTH , and ionized calcium were 15.1±3.7ng/ml, 46.1±18.5 ng/ml and 1.3±0.06 mmol/l, respectively. For urinary calcium and phosphate were 126.8±45.3mg/dl and 715.0±277.3 mg/dl, respectively. See table for within-diet changes. The DASH diet, net of control, reduced vitamin D by -1.29ng/ml (P= 0.005). In stratified analyses, the reduction in vitamin D appeared more prominent in blacks, but the p-value for interaction (race*diet) was non-significant (P=0.21). Otherwise, the DASH diet had no significant effect on the other markers, net of control. Compared to control, the fruit & vegetable diet reduced urinary calcium and phosphorus excretion. Conclusion: The DASH diet modestly reduced vitamin D levels among all participants, with potentially larger effects in blacks. The reduction in vitamin D levels might have resulted from the lower fat content of the DASH diet. Overall, during the eight-weeks of intervention, no major harm or benefit of the DASH diet was documented on biomarkers related to bone-mineral metabolism.

scholarly journals Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

2021 ◽  
Vol 23 (1) ◽  
pp. 44
Author(s):  
Mirjana Babić Leko ◽  
Nikolina Pleić ◽  
Ivana Gunjača ◽  
Tatijana Zemunik
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Environmental Factors ◽  
Bone Mineral ◽  
Genetic Factors ◽  
Mineral Metabolism ◽  
Lifestyle Factors ◽  
The Body ◽  
Phosphate Homeostasis ◽  
Bone Mineral Metabolism

Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.

scholarly journals The Role of Vitamin D in Small Animal Bone Metabolism

Metabolites ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 496
Author(s):  
Rafael Vessecchi Amorim Zafalon ◽  
Bruna Ruberti ◽  
Mariana Fragoso Rentas ◽  
Andressa Rodrigues Amaral ◽  
Thiago Henrique Annibale Vendramini ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Mammalian Species ◽  
Small Animal ◽  
Sun Exposure ◽  
Vitamin D Metabolism ◽  
Bone Mineral Metabolism ◽  
Animal Bone

Dogs and cats have differences in vitamin D metabolism compared to other mammalian species, as they are unable to perform vitamin D cutaneous synthesis through sun exposure. Therefore, they are dependent on the dietary intake of this nutrient. The classic functions of vitamin D are to stimulate intestinal calcium and phosphate absorption, renal calcium and phosphate reabsorption and regulate bone mineral metabolism. Thus, it is an important nutrient for calcium and phosphorus homeostasis. This review highlights the evidence of the direct and indirect actions of vitamin D on bone mineral metabolism, the consequences of nutritional imbalances of this nutrient in small animals, as well as differences in vitamin D metabolism between different size dogs.

scholarly journals Integrated Medicine with vegetable derived antioxidant and vitamin D : effects on oxidative stress and bone mineral metabolism of aged patients with renal disease

2016 ◽  
Vol 6 (6) ◽  
pp. 379 ◽  
Author(s):  
Francesco Carluccio ◽  
Macello Lenucci ◽  
Gabriella Piro ◽  
Werner Siems ◽  
Josè Luño
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Integrated Medicine ◽  
Bone Mineral Metabolism

Background: Aging and chronic kidney disease (CKD) are associated with bone mineral metabolism disorders, in addition to disarrangement of trabeculae structure and bone architecture. Increased alkaline phosphatase (ALP) and parathyroid hormone (PTH) have been related with abnormal bone turn over. Lycopene, a plant derived micronutrient, has strong quenching and free radical scavenging attitude. Objectives: This study aimed to evaluate the effects of lycopene and calcifediol (25 OH D3) based Integrated Medicine on ALP, PTH and oxidative stress. Methods: In octogenarians, nonagenarians and centenarians with chronic kidney disease (GFR :45 ±10,4 ml/min/1,73 m2), vitamin D deficiency and abnormal ALP, PTH blood values, the effects of daily lycopene supplementation on blood oxysterols and on 4-hydroxy-2,3-trans- nonenal (4-HNE) as markers of oxidative stress were evaluated. The effects of calcifediol administration together with daily lycopene supplementation on PTH and ALP blood concentrations were also investigated. Results: Daily lycopene supplementation induced a reduction of oxysterols (α-triol: 0.40 ± 0.07 μg / L vs 0.32 ± 0, 04 μg / L and β-epoxi cholesterol: 5.3 ± 1.3 μg / L vs 3.7 ± 0.6 μg / L) but not of 4-HNE (0.27 ± 0.18 nmol / L vs 0.25 ± 0.20 nmol / L). Vitamin D added to lycopene for two weeks decreased the blood values of ALP (106 ± 40 U / L vs 69 ± 19 U / L) and PTH (108 ±42 pg/ml vs 66± 21 pg/ml). Conclusion: Tomato derived lycopene, with daily supplements, decreased cholesterol oxidation products. Calcifediol and vegetable derived antioxidant daily supplementations were associated to normalization of ALP and PTH. Keywords: oxysterols; 4-hydroxynonenal; lycopene; alkaline phosphatase; parathyroid hormone; chronic kidney disease (CKD) 

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