The effects of intravenous norepinephrine on the local coupling between glucose utilization and blood flow in the rat brain

1983 ◽  
Vol 398 (2) ◽  
pp. 134-138 ◽  
Author(s):  
W. Kuschinsky ◽  
S. Suda ◽  
R. B�nger ◽  
S. Yaffe ◽  
L. Sokoloff
Keyword(s):  
Blood Flow ◽  
Rat Brain ◽  
Glucose Utilization ◽  
Local Coupling

DNA synthesis, blood flow, and glucose utilization in experimental rat brain tumors

1989 ◽  
Vol 70 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Akira Watanabe ◽  
Ryuichi Tanaka ◽  
Norio Takeda ◽  
Kazuo Washiyama
Keyword(s):  
Blood Flow ◽  
Brain Tumors ◽  
Rat Brain ◽  
Glucose Utilization ◽  
Acid Synthesis ◽  
S Phase ◽  
Immunoperoxidase Staining ◽  
Content Type ◽  
Contralateral Cortex ◽  
Autoradiographic Technique

✓ The relationships between distribution of deoxyribonucleic acid (DNA)-synthesizing cells (S-phase cells) and blood flow and glucose utilization were investigated in rat brain tumors using an autoradiographic technique and immunoperoxidase staining for bromodeoxyuridine (BUdR). Two strains of rat brain tumor were used: strain A and B, both induced by the Rous sarcoma virus. Strain A was biologically more malignant than strain B. The blood flow was unevenly distributed in the tumor; compared with the contralateral cortex, the average blood flow in the tumor was about 50% in strain A and 60% in strain B. The distribution of blood flow did not correlate with the distribution of S-phase cells or with the distribution of vessels in the tumor in either strain A or B. The average glucose utilization in strain A was about 250% and in strain B about 170% of that of the contralateral cortex. The high glucose utilization area correlated well with the distribution of BUdR-positive nuclei in strain B. These findings suggest that the biological malignancy of a tumor correlates with glucose utilization rather than with blood flow, and that malignant brain tumors show a marked increase in glucose utilization for nucleic acid synthesis.

scholarly journals Influence of γ-Hydroxybutyrate on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow in the Rat Brain

1985 ◽  
Vol 5 (1) ◽  
pp. 58-64 ◽  
Author(s):  
W. Kuschinsky ◽  
S. Suda ◽  
L. Sokoloff
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Glucose Utilization ◽  
Local Cerebral Blood Flow ◽  
Local Cerebral Glucose Utilization ◽  
Cerebral Glucose Utilization ◽  
Minor Degree ◽  
A Minor ◽  
The Relationship

The relationship between local cerebral glucose utilization (LCGU) and local CBF (LCBF) was examined during the action of γ-hydroxybutyrate (GHB) (900 mg/kg i.v.) in conscious rats. GHB induced discrepant effects on blood flow and metabolism. LCGU was markedly depressed in all structures examined, whereas LCBF was differently affected in that no related changes were observed. Global glucose utilization was markedly depressed (- 51%), whereas global blood flow was not significantly altered. The marked dissociation between the changes in global glucose utilization and global blood flow induced by GHB is reflected only to a minor degree in the local values inasmuch as the correlation between LCGU and LCBF was only slightly weakened and its heterogeneity was increased.

scholarly journals Erratum

1991 ◽  
Vol 11 (4) ◽  
pp. 706-706
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Equilibrium State ◽  
Rat Brain ◽  
G Proteins ◽  
Pertussis Toxin ◽  
Adp Ribosylation ◽  
Gtp Binding ◽  
Reconstituted System ◽  
Α Subunits

Ischemia of Rat Brain Decreases Pertussis Toxin-Catalyzed [32P] ADP Ribosylation of GTP-Binding Proteins (Gi1 and G0) in Membranes Katsunobu Takenaka, Yasunori Kanaho, Koh-ichi Nagata, Noboru Sakai, Hiromu Yamada, Yoshinori Nozawa [ Originally published in Journal of Cerebral Blood Flow and Metabolism 1991;11:155–160] On page 158 of the above, arrows were erroneously deleted from the equation in the following passage: Heterotrimers of G proteins that bind GDP to α subunits seem to be the preferred substrates for PTcatalyzed ADP ribosylation since guanine nucleotides (GDP and GTP) and 13'Y subunits stimulate ADP ribosylation in the reconstituted system and in membranes (Tsai et aI., 1984). These results indicate that the G proteins may exist at the equilibrium state as shown below: This omission was the result of a typesetting error, which the publisher regrets.

LOCAL CEREBRAL BLOOD FLOW AND GLUCOSE UTILIZATION IN SCHIZOPHRENIA. I. CATATONIC TYPE.

1992 ◽  
Vol 15 ◽  
pp. 258B
Author(s):  
K. Satoh ◽  
M. Narita ◽  
T. Someya ◽  
S. Takahashi ◽  
T. Suzuki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Glucose Utilization ◽  
Local Cerebral Blood Flow

Correlation between Hepatic Tumor Blood Flow and Glucose Utilization in a Rabbit Liver Tumor Model

Radiology ◽  
2006 ◽  
Vol 239 (3) ◽  
pp. 740-750 ◽  
Author(s):  
Errol E. Stewart ◽  
Xaiogang Chen ◽  
Jennifer Hadway ◽  
Ting-Yim Lee
Keyword(s):  
Blood Flow ◽  
Liver Tumor ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Hepatic Tumor ◽  
Rabbit Liver ◽  
Tumor Blood Flow

Quantitative Measurements of Regional Glucose Utilization and Rate of Valine Incorporation into Proteins by Double-Tracer Autoradiography in the Rat Brain Tumor Model

1989 ◽  
Vol 9 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Michihiro Kirikae ◽  
Mirko Diksic ◽  
Y. Lucas Yamamoto
Keyword(s):  
Protein Synthesis ◽  
Brain Tumor ◽  
Rat Brain ◽  
Brain Tissue ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Normal Brain ◽  
Normal Brain Tissue ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

We examined the rate of glucose utilization and the rate of valine incorporation into proteins using 2-[18F]fluoro-2-deoxyglucose and L-[1-14C]-valine in a rat brain tumor model by quantitative double-tracer autoradiography. We found that in the implanted tumor the rate of valine incorporation into proteins was about 22 times and the rate of glucose utilization was about 1.5 times that in the contralateral cortex. (In the ipsilateral cortex, the tumor had a profound effect on glucose utilization but no effect on the rate of valine incorporation into proteins.) Our findings suggest that it is more useful to measure protein synthesis than glucose utilization to assess the effectiveness of antitumor agents and their toxicity to normal brain tissue. We compared two methods to estimate the rate of valine incorporation: “kinetic” (quantitation done using an operational equation and the average brain rate coefficients) and “washed slices” (unbound labeled valine removed by washing brain slices in 10% thrichloroacetic acid). The results were the same using either method. It would seem that the kinetic method can thus be used for quantitative measurement of protein synthesis in brain tumors and normal brain tissue using [11C]-valine with positron emission tomography.

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