Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7?36 amide] in the fasting state in healthy subjects

1995 ◽  
Vol 32 (1) ◽  
pp. 13-16 ◽  
Author(s):  
C. Qualmann ◽  
M. A. Nauck ◽  
J. J. Holst ◽  
C. �rskov ◽  
W. Creutzfeldt
Keyword(s):  
Healthy Subjects ◽  
Fasting State ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Subcutaneous glucagon-like peptide-1 (7-36) amide is insulinotropic and can cause hypoglycaemia in fasted healthy subjects

1998 ◽  
Vol 95 (6) ◽  
pp. 719-724 ◽  
Author(s):  
C. Mark B. EDWARDS ◽  
Jeannie F. TODD ◽  
Mohammad A. GHATEI ◽  
Stephen R. BLOOM
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Healthy Subjects ◽  
Therapeutic Potential ◽  
Double Blind ◽  
Gut Hormone ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

1. Glucagon-like peptide-1 (7-36) amide (GLP-1) is a gut hormone released postprandially that stimulates insulin secretion, suppresses glucagon secretion and delays gastric emptying. The insulinotropic action of GLP-1 is more potent under hyperglycaemic conditions. Several published studies have indicated the therapeutic potential of subcutaneous GLP-1 in non-insulin-dependent (Type 2) diabetes mellitus. 2. We investigated whether subcutaneous GLP-1, at a dose shown to improve glycaemic control in early Type 2 diabetes, is insulinotropic at normal fasting glucose concentrations. A double-blind, randomized, crossover study of 10 healthy subjects injected with GLP-1 or saline subcutaneously after a 16 h fast was performed. The effect on cardiovascular parameters was also examined. 3. GLP-1 caused a near 5-fold rise in plasma insulin concentration. After treatment with GLP-1, circulating plasma glucose concentrations fell below the normal range in all subjects. One subject had symptoms of hypoglycaemia after GLP-1. A rise in pulse rate was found which correlated with the fall in plasma glucose concentration. An increase in blood pressure occurred with GLP-1 injection which was seen at the same time as the rise in plasma GLP-1 concentrations. 4. This study indicates that subcutaneous GLP-1 can override the normal homoeostatic mechanism maintaining fasting plasma glucose in man, and is also associated with an increase in blood pressure.

Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial

Nutrition ◽  
2018 ◽  
Vol 55-56 ◽  
pp. 125-130 ◽  
Author(s):  
Amornpan Lertrit ◽  
Sasinee Srimachai ◽  
Sunee Saetung ◽  
Suwannee Chanprasertyothin ◽  
La-or Chailurkit ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects

2011 ◽  
Vol 107 (10) ◽  
pp. 1445-1451 ◽  
Author(s):  
Riitta Törrönen ◽  
Essi Sarkkinen ◽  
Tarja Niskanen ◽  
Niina Tapola ◽  
Kyllikki Kilpi ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Serum Insulin ◽  
Venous Blood ◽  
Postprandial Glucose ◽  
Carbohydrate Ingestion ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Meal Ingestion ◽  
Single Blind ◽  
Modest Effect

Berries are often consumed with sucrose. They are also rich sources of polyphenols which may modulate glycaemia after carbohydrate ingestion. The present study investigated the postprandial glucose, insulin and glucagon-like peptide 1 (GLP-1) responses to sucrose ingested with berries, in comparison with a similar sucrose load without berries. A total of twelve healthy subjects were recruited to a randomised, single-blind, placebo-controlled crossover study. They participated in two meal tests on separate days. The berry meal was a purée (150 g) made of bilberries, blackcurrants, cranberries and strawberries with 35 g sucrose. The control meal included the same amount of sucrose and available carbohydrates in water. Fingertip capillary and venous blood samples were taken at baseline and at 15, 30, 45, 60, 90 and 120 min after starting to eat the meal. Glucose, insulin and GLP-1 concentrations were determined from the venous samples, and glucose also from the capillary samples. Compared to the control meal, ingestion of the berry meal resulted in lower capillary and venous plasma glucose and serum insulin concentrations at 15 min (P = 0·021,P < 0·007 andP = 0·028, respectively), in higher concentrations at 90 min (P = 0·028,P = 0·021 andP = 0·042, respectively), and in a modest effect on the GLP-1 response (P = 0·05). It also reduced the maximum increases of capillary and venous glucose and insulin concentrations (P = 0·009,P = 0·011 andP = 0·005, respectively), and improved the glycaemic profile (P < 0·001 andP = 0·003 for capillary and venous samples, respectively). These results suggest that the glycaemic control after ingestion of sucrose can be improved by simultaneous consumption of berries.

Jabuticaba juice improves postprandial glucagon-like peptide-1 and antioxidant status in healthy adults: a randomized crossover trial

2021 ◽  
pp. 1-29
Author(s):  
Marina V. Geraldi ◽  
Cínthia B. B. Cazarin ◽  
Marcelo Cristianini ◽  
Ana C. Vasques ◽  
Bruno Geloneze ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Healthy Subjects ◽  
Antioxidant Status ◽  
Metabolic Diseases ◽  
Area Under The Curve ◽  
C Peptide ◽  
Test Product ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Carbohydrate Meal

Abstract Jabuticaba is a Brazilian berry rich in polyphenols, which may exert beneficial effects on metabolic diseases. This randomized crossover study aimed to determine the effects of jabuticaba juice (250 ml in a portion) on postprandial response. Sixteen healthy subjects (11 women; 5 men; 28.4 ± 3.8 years old; body mass index (BMI) 21.7 ± 2.3 kg m−2) consumed two test products after fasting overnight in a randomized controlled crossover design. Each test product portion had a similar composition of sugar components: 250 mL water with glucose, fructose, colored with artificial non-caloric food colorings (placebo); and 250 mL of jabuticaba juice. Beverages were administered immediately before a carbohydrate meal. Blood samples were collected at 0, 15, 30, 45, 60, 90, and 120 min after each test product to analyze the concentrations of glucose, insulin, C-peptide, antioxidant capacity, plasma glucagon-like peptide-1 (GLP-1), and appetite sensations. Compared to the placebo, the intake of jabuticaba juice resulted in a higher GLP-1 response as the area under the curve (AUC) and peaking at 60 min. Jabuticaba juice also resulted in higher antioxidant capacity. Postprandial glucose, insulin, C-peptide levels, and appetite sensations were not significantly different between tests. In conclusion, 250 mL of jabuticaba juice before a carbohydrate meal was able to improve the antioxidant status and GLP-1 concentrations in healthy subjects.

No increased risk of hypoglycaemic episodes during 48 h of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects

2009 ◽  
Vol 71 (4) ◽  
pp. 500-506 ◽  
Author(s):  
Susanne Lerche ◽  
Liselotte Soendergaard ◽  
Joergen Rungby ◽  
Niels Moeller ◽  
Jens Juul Holst ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Increased Risk ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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