Synthesis of a cyclic tripeptide modelling the ?active? conformation of oxytocin

1977 ◽  
Vol 13 (3) ◽  
pp. 373-374
Author(s):  
E. I. Grigor'ev ◽  
E. A. Krol' ◽  
O. A. Kaurov
Keyword(s):  
Active Conformation ◽  
Cyclic Tripeptide

Modeling the Active Conformation of Human µ Opioid Receptor

2014 ◽  
Vol 11 (9) ◽  
pp. 1053-1061 ◽  
Author(s):  
Agnieszka Kaczor ◽  
Damian Bartuzi ◽  
Dariusz Matosiuk
Keyword(s):  
Opioid Receptor ◽  
Active Conformation

The Role of the N-Terminal Domain in the Regulation of the “Constitutively Active” Conformation of Protein Kinase CK2α: Insight from a Molecular Dynamics Investigation

ChemMedChem ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. 1207-1216 ◽  
Author(s):  
Andrea Cristiani ◽  
Giorgio Costa ◽  
Giorgio Cozza ◽  
Flavio Meggio ◽  
Leonardo Scapozza ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Protein Kinase ◽  
Active Conformation ◽  
Terminal Domain ◽  
Constitutively Active

scholarly journals A Novel, Enzymatically Active Conformation of theEscherichia coliNADH:Ubiquinone Oxidoreductase (Complex I)

2002 ◽  
Vol 277 (20) ◽  
pp. 17970-17977 ◽  
Author(s):  
Bettina Böttcher ◽  
Dierk Scheide ◽  
Micaela Hesterberg ◽  
Luitgard Nagel-Steger ◽  
Thorsten Friedrich
Keyword(s):  
Complex I ◽  
Active Conformation

scholarly journals The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Renata Grzela ◽  
Julien Nusbaum ◽  
Sonia Fieulaine ◽  
Francesco Lavecchia ◽  
Willy V. Bienvenut ◽  
...  
Keyword(s):  
Peptide Deformylase ◽  
Active Conformation ◽  
Terminal Residue

scholarly journals Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

2021 ◽  
Vol 7 (15) ◽  
pp. eabd4420
Author(s):  
Trevor van Eeuwen ◽  
Tao Li ◽  
Hee Jong Kim ◽  
Jose J. Gorbea Colón ◽  
Mitchell I. Parker ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Initiation ◽  
Activation Loop ◽  
Active Conformation ◽  
General Transcription Factor ◽  
Cryo Electron Microscopy ◽  
Proposed Model ◽  
Carboxyl Terminal ◽  
Catalytic Cleft

During transcription initiation, the general transcription factor TFIIH marks RNA polymerase II by phosphorylating Ser5 of the carboxyl-terminal domain (CTD) of Rpb1, which is followed by extensive modifications coupled to transcription elongation, mRNA processing, and histone dynamics. We have determined a 3.5-Å resolution cryo–electron microscopy (cryo-EM) structure of the TFIIH kinase module (TFIIK in yeast), which is composed of Kin28, Ccl1, and Tfb3, yeast homologs of CDK7, cyclin H, and MAT1, respectively. The carboxyl-terminal region of Tfb3 was lying at the edge of catalytic cleft of Kin28, where a conserved Tfb3 helix served to stabilize the activation loop in its active conformation. By combining the structure of TFIIK with the previous cryo-EM structure of the preinitiation complex, we extend the previously proposed model of the CTD path to the active site of TFIIK.

Dopamine receptor blockade by imidoline and its proposed active conformation

1980 ◽  
Vol 68 (2) ◽  
pp. 139-146 ◽  
Author(s):  
B.Kenneth Koe ◽  
Susan W. Koch ◽  
Beryl W. Dominy
Keyword(s):  
Dopamine Receptor ◽  
Receptor Blockade ◽  
Active Conformation
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