Modulation of uptake2 of3H-(�)-isoprenaline by isoprenaline-induced depolarization of rat salivary gland cells

1986 ◽  
Vol 334 (4) ◽  
pp. 388-392 ◽  
Author(s):  
U. Trendelenburg ◽  
Martina Fischer
Keyword(s):  
Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells ◽  
Rat Salivary Gland

Rate of protein synthesis in rat salivary gland cells after pilocarpine or feeding

1975 ◽  
Vol 164 (4) ◽  
pp. 447-456 ◽  
Author(s):  
A. H. Kuijper-Lenstra ◽  
M. F. Kramer ◽  
W. J. van Venrooij
Keyword(s):  
Protein Synthesis ◽  
Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells ◽  
Rat Salivary Gland

Upregulation of P2Y2 nucleotide receptors in rat salivary gland cells during short-term culture

1997 ◽  
Vol 273 (3) ◽  
pp. C1100-C1107 ◽  
Author(s):  
J. T. Turner ◽  
G. A. Weisman ◽  
J. M. Camden
Keyword(s):  
Salivary Gland ◽  
Receptor Activity ◽  
P2y2 Receptor ◽  
P2y2 Receptors ◽  
Gland Cells ◽  
Salivary Gland Cells ◽  
Normal Rat ◽  
Rat Salivary Gland ◽  
Short Term Culture

In contrast to the widespread expression of G protein-coupled P2Y2 receptors for extracellular nucleotides in permanent cell lines of salivary gland origin, there is less evidence for robust P2Y2 receptor activity in normal rat salivary gland cells assayed immediately after isolation. We examined the effect of short-term culture (3 h to 6 days) of normal rat submandibular gland (SMG) cells on P2Y2 receptor activity and mRNA expression. Results indicate that increases in the intracellular free Ca2+ concentration in SMG cells in response to the P2Y2 receptor agonist UTP (100 microM) were detectable after 3 h in culture and that after 3 days in culture the magnitude of the response to UTP was similar to that obtained with maximal muscarinic cholinoceptor activation. The Ca2+ mobilization response exhibited the pharmacological profile (UTP = ATP > 2-methylthioadenosine 5'-triphosphate) typical of the P2Y2 receptor subtype and was accompanied by enhanced production of inositol phosphates, reflecting the activation of phospholipase C ubiquitously associated with P2Y2 receptors. The time-dependent increase in P2Y2 receptor activity was accompanied by an increase in the steady-state level of P2Y2 receptor mRNA, as assessed by reverse transcription-polymerase chain reaction. Other studies revealed that the increased P2Y2 receptor activity was independent of cell proliferation, was similar in serum-containing and defined culture media, and was blocked by inhibitors of transcription and translation. Upregulation of the P2Y2 receptor was observed in both acinar cell- and ductal cell-enriched cultures of the SMG and in cells isolated from rat parotid and sublingual glands but not in cells isolated from the pancreas. These in vitro results were complemented by in vivo studies in which P2Y2 receptor activity and mRNA levels were increased in SMG after ligation of the main excretory duct but were not increased in the contralateral, nonligated gland. These findings suggest that changes in the expression and activity of the P2Y2 receptor in salivary gland cells may be related to pathological challenges to the gland in vivo.

scholarly journals Isoproterenol evokes extracellular Ca2+ spikes due to secretory events in salivary gland cells.

1998 ◽  
Vol 273 (17) ◽  
pp. 10806
Author(s):  
Pavel Belan ◽  
Julie Gardner ◽  
Oleg Gerasimenko ◽  
Chris Lloyd Mills ◽  
Ole H. Petersen ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells

scholarly journals Trp1, a candidate protein for the store-operated Ca2+ influx mechanism in salivary gland cells.

2000 ◽  
Vol 275 (13) ◽  
pp. 9890-9891
Author(s):  
Xibao Liu ◽  
Weiching Wang ◽  
Brij B. Singh ◽  
Timothy Lockwich ◽  
Julie Jadlowiec ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells ◽  
Candidate Protein

Cyclic ADP-ribose Induces Ca2+ Release from Caffeine-insensitive Ca2+ Pools in Canine Salivary Gland Cells

1998 ◽  
Vol 77 (10) ◽  
pp. 1807-1816 ◽  
Author(s):  
H. Yamaki ◽  
K. Morita ◽  
S. Kitayama ◽  
Y. Imai ◽  
K. Itadani ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells ◽  
Cyclic Adp Ribose

scholarly journals Replication of Oral BK Virus in Human Salivary Gland Cells

2013 ◽  
Vol 88 (1) ◽  
pp. 559-573 ◽  
Author(s):  
R. Burger-Calderon ◽  
V. Madden ◽  
R. A. Hallett ◽  
A. D. Gingerich ◽  
V. Nickeleit ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Bk Virus ◽  
Human Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells
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