Dissociation between duration of plasma catecholamine and blood pressure responses to beta-adrenergic blockade in normotensive subjects during physical exercise

1981 ◽  
Vol 19 (2) ◽  
pp. 83-88 ◽  
Author(s):  
G. Planz ◽  
R. Planz
Keyword(s):  
Blood Pressure ◽  
Physical Exercise ◽  
Plasma Catecholamine ◽  
Adrenergic Blockade ◽  
Beta Adrenergic ◽  
Normotensive Subjects ◽  
Blood Pressure Responses

Cardiac responses to acute insulin-induced hypoglycemia in humans

1990 ◽  
Vol 258 (6) ◽  
pp. H1775-H1779 ◽  
Author(s):  
B. M. Fisher ◽  
G. Gillen ◽  
D. A. Hepburn ◽  
H. J. Dargie ◽  
B. M. Frier
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Ejection Fraction ◽  
Arterial Blood Pressure ◽  
Mean Arterial Blood Pressure ◽  
Adrenergic Blockade ◽  
Beta Adrenergic ◽  
Cholinergic Blockade ◽  
Arterial Blood ◽  
Blood Pressure Responses

The effects of acute hypoglycemia on the heart and cardiovascular system were examined in humans using radioisotopic techniques, complemented by measurement of heart rate and blood pressure. The heart rate increased from 62 +/- 3 to 87 +/- 3 beats/min in response to hypoglycemia; this increase was accompanied by a significant increase in systolic blood pressure, a fall in diastolic blood pressure, with no change in the mean arterial blood pressure. The left ventricular ejection fraction increased from 47 +/- 3 (SE) to 72 +/- 5% in response to hypoglycemia. The increases in heart rate and ejection fraction were abolished during parenteral nonselective beta-adrenergic blockade with propranolol but were unaffected by either alpha-adrenergic blockade with phentolamine or cholinergic blockade with atropine. During beta-adrenergic blockade, there were significant increases in diastolic and mean arterial blood pressure in response to hypoglycemia. During alpha-adrenergic blockade the systolic, diastolic, and mean arterial pressures fell significantly after hypoglycemia. The blood pressure responses to hypoglycemia were unaffected by cholinergic blockade. Thus the increases in ejection fraction and in heart rate in response to hypoglycemia are mediated by beta-adrenoreceptors, whereas the blood pressure responses to hypoglycemia are mediated by alpha- and by beta-adrenoreceptors.

scholarly journals High sodium intake alters the hemodynamic response to mental stress in normotensive subjects after systemic beta adrenergic blockade

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Bruno Moreira Silva ◽  
Rachel L. Elvebak ◽  
Jean N. Knutson ◽  
Nathaniel D. Warner ◽  
Michael J. Joyner ◽  
...  
Keyword(s):  
Mental Stress ◽  
Sodium Intake ◽  
Hemodynamic Response ◽  
Adrenergic Blockade ◽  
Beta Adrenergic ◽  
High Sodium ◽  
High Sodium Intake ◽  
Normotensive Subjects

Cardiovascular and norepinephrine responses of men and women to two cold pressor tests

1992 ◽  
Vol 70 (1) ◽  
pp. 36-42 ◽  
Author(s):  
J. K. McLean ◽  
P. Sathasivam ◽  
K. MacNaughton ◽  
T. E. Graham
Keyword(s):  
Blood Pressure ◽  
Gender Differences ◽  
Heart Rate ◽  
Latin Square ◽  
Cold Pressor ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
The Face ◽  
Blood Pressure Responses ◽  
Venous Plasma

Two types of cold pressor tests were used to study gender differences in cardiovascular and plasma catecholamine responses. Ten male and ten female, young, healthy Caucasian subjects participated. The tests consisted of (1) 5 °C air blown at 3.5–4 m/s onto part of the face for 4 min and (2) the open right hand immersed to the wrist in water at 5 °C for 4 min. Heart rate, blood pressure (BP), and venous plasma norepinephrine were collected before, during, and 5 min after the 4 min of cold exposures. Test order was decided by a Latin square design, and the subjects rested in a quiet room for 30 min between the two tests. All parameters demonstrated significant (p < 0.01) increases from rest during the cold tests. Gender differences were significant (p < 0.01) in diastolic and systolic BP in each test with the males having a greater response, but gender differences were not found in heart rate or norepinephrine concentration. The study demonstrated that gender differences exist in the blood pressure responses to local cold, but that the mechanisms involved do not include a parallel difference in heart rate or venous plasma norepinephrine concentration.Key words: blood pressure, gender differences, stroke volume.

Blood pressure responses to hypnotic and nonhypnotic suggestions in normotensive subjects

1986 ◽  
Vol 21 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Helge Sletvold ◽  
Geirr Molde Jensen ◽  
K. Gunnar Götestam
Keyword(s):  
Blood Pressure ◽  
Normotensive Subjects ◽  
Blood Pressure Responses

The Urinary Excretion of Catecholamines and Their Derivatives in Primary Hypertension in Man

1977 ◽  
Vol 52 (3) ◽  
pp. 319-323 ◽  
Author(s):  
R. F. Bing ◽  
J. Harlow ◽  
A. J. Smith ◽  
M. M. Townshend
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Urinary Excretion ◽  
High Plasma ◽  
Plasma Catecholamine ◽  
Elevated Blood ◽  
Hypertensive Patients ◽  
Catecholamine Excretion ◽  
Normotensive Subjects ◽  
Plasma Catecholamine Concentrations

1. The 24 h urinary excretion of adrenaline, noradrenaline, normetadrenaline, metadrenaline and vanilloylmandelic acid has been compared in 17 male normotensive subjects and 25 age-matched male hypertensive patients studied under similar in-patient conditions. 2. 24 h urinary metadrenaline was significantly lower in the hypertensive patients. With this exception, no significant differences were found between the two groups when the total 24 h excretion of free catecholamines and their metabolites was analysed. 3. Diurnal variation in free catecholamine excretion was found in both normotensive and hypertensive subjects. There was no corresponding variation in metabolite excretion. 4. No correlation could be established between systolic or diastolic blood pressure and the amounts of the catecholamines or their metabolites in the urine of either group. 5. The results are considered in the light of recent work demonstrating high plasma catecholamine concentrations in hypertension. They lend no support to the concept that excessive circulating catecholamines are responsible for the elevated blood pressure in essential hypertension.

scholarly journals Beta-adrenergic Receptor Blockade Effects on Cardio-pulmonary Exercise Testing

2021 ◽  
Author(s):  
Kevin Forton ◽  
Michel Lamotte ◽  
Alexis Gillet ◽  
Martin Chaumont ◽  
Van De Borne Philippe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Single Dose ◽  
Adrenergic Receptor ◽  
Adrenergic Blockade ◽  
Receptor Blockade ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Chronotropic Response ◽  
Adrenergic Receptor Blockade

Abstract Background: Beta-blockers are increasingly prescribed while the effects of beta-adrenergic receptor blockade on cardio-pulmonary exercise test (CPET) derived parameters remain under-studied. Methods: 21 young healthy adults repeated 3 CPET at an interval of 7 days at the same time of the day. The tests were performed 3 hours after a random, double blind, cross-over single dose intake of placebo, 2.5 mg bisoprolol or 5 mg bisoprolol. Gaz exchange, heart rate and blood pressure were measured at rest and during cyclo-ergometric CPET.Results: Maximal workload and VO2max were unaffected by the treatment, with maximal respiratory exchange ratio > 1.15 in all tests. A beta-blocker dose-dependent effect reduced resting and maximal blood pressure and heart rate and the chronotropic response to exercise, evaluated by the heart rate/VO2 slope (placebo: 2,9 ± 0,4 beat/ml/kg; 2,5 mg bisoprolol: 2,4 ± 0,5 beat/ml/kg; 5 mg bisoprolol: 2,3 ± 0,4 beat/ml/kg, p<0.001). Ventilation efficiency measured by the VE/VCO2 slope and the ventilatory equivalent for CO2 at the ventilatory threshold were not affected by beta1-receptor blockade. Post-exercise chronotropic recovery measured after 1 min was enhanced under beta1-blocker (placebo: 26 ± 7 bpm; 2,5 mg bisoprolol: 32 ± 6 bpm; 5 mg bisoprolol: 33 ± 6 bpm, p<0.01).Conclusion: The present results suggest that a single dose of bisoprolol does not affect metabolism, respiratory response and exercise capacity. However, beta-adrenergic blockade dose-dependently reduced exercise hemodynamic response by lowering the pressure and chronotropic responses.

Plasma catecholamine responses to exercise after training with beta-adrenergic blockade

1990 ◽  
Vol 68 (2) ◽  
pp. 586-593 ◽  
Author(s):  
E. E. Wolfel ◽  
W. R. Hiatt ◽  
H. L. Brammell ◽  
V. Travis ◽  
L. D. Horwitz
Keyword(s):  
Exercise Training ◽  
Maximal Exercise ◽  
Submaximal Exercise ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Adrenergic Blockade ◽  
Absolute Level ◽  
Beta Adrenergic ◽  
Exercise Training Program ◽  
Induced Changes

Exercise training has been shown to decrease plasma norepinephrine (NE) and epinephrine (EPI) levels during absolute levels of submaximal exercise, which may reflect alterations in sympathetic tone as a result of training. To determine if beta-adrenergic blockade altered these changes in the plasma concentration of catecholamines with exercise conditioning, we studied the effects of beta-adrenergic blockade on NE and EPI at rest and during exercise in 24 healthy, male subjects after a 6-wk exercise training program. The subjects were randomized to placebo (P), atenolol 50 mg twice daily (A), and nadolol 40 mg twice daily (N). There were no changes in resting NE and EPI compared with pretraining values in any subject group. During the same absolute level of submaximal exercise NE decreased in P and A but was unchanged in N, whereas EPI decreased only in P. At maximal exercise all three groups developed significant increases in NE after training that paralleled increases in systolic blood pressure. EPI at maximal exercise increased after training with N but was unchanged with P or A. These training-induced changes in plasma catecholamine levels were masked or blunted when the A and N groups were studied while still on medication after training. Thus beta-adrenergic blockade has important effects on adaptations of the sympathetic nervous system to training, especially during submaximal exercise.

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