Some laws of the polycondensation of activated esters of amino acids and peptides

1973 ◽  
Vol 9 (6) ◽  
pp. 739-744
Author(s):  
A. B. Zegel'man ◽  
T. Yu. Yusupov ◽  
Sh. Kh. Khalikov ◽  
V. A. Shibnev
Keyword(s):  
Amino Acids ◽  
Activated Esters

Amine-Reactive Activated Esters of meso-CarboxyBODIPY: Fluorogenic Assays and Labeling of Amines, Amino Acids, and Proteins

2020 ◽  
Vol 142 (20) ◽  
pp. 9231-9239
Author(s):  
Sungjin Jeon ◽  
Tae-Il Kim ◽  
Hanyong Jin ◽  
Uisung Lee ◽  
Jeehyeon Bae ◽  
...  
Keyword(s):  
Amino Acids ◽  
Activated Esters

ChemInform Abstract: Synthesis of Nucleopeptides Using Mixed Anhydrides and Activated Esters of Amino Acids.

ChemInform ◽  
2010 ◽  
Vol 27 (51) ◽  
pp. no-no
Author(s):  
YU. P. SHVACHKIN ◽  
A. P. SMIRNOVA ◽  
N. M. ERMAK ◽  
V. V. KNYAZEVA
Keyword(s):  
Amino Acids ◽  
Activated Esters ◽  
Mixed Anhydrides

Pteridines, XCV

Pteridines ◽  
1989 ◽  
Vol 1 (4) ◽  
pp. 199-210 ◽  
Author(s):  
Ronan John Lockart ◽  
Wolfgang Pfleiderer
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Acid Anhydride ◽  
Activated Esters ◽  
Amino Acid Conjugates ◽  
Catalytic Hydrogenolysis ◽  
Benzyl Esters

SummaryA series of new amino acid-tetrahydropterin-conjugates has been synthesized starting from N 2-isobutyryl-6,7- dimethyl-5,6,7,8-tetrahydropterin (7). The amino acids have been attached in form of their esters (10 - 16) via a succinyl spacer to the N-5 position (17 - 23) or directly via the carboxyl function applying CBZprotected activated esters (35, 39). Acylation of 7 with N-benzyloxycarbonylglutamic acid anhydride led to the y-glutamyl derivative 41. Selective deblocking experiments were achieved by catalytic hydrogenolysis to cleave the benzyl esters (24-28, 36, 42) and by DBU treatment to eliminate the p-nitrophenylethyl group (24, 25) respectively. Further reaction with ammonia hydrolysed the isobutyryl group to give the free tetrahydropterin-amino acid-conjugates 29 - 32, 37 and 43. Also a carbamoyl-type conjugate (45) was obtained from 7 and benzyl phenylalanine N-carbonylimidazolide (44). The newly synthesized compounds have been characterized by elemental analysis, UV and IH-NMR spectra.

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