Beta-adrenergic blocking activity and haemodynamic effects in man of K� 1313, a new beta-adrenergic antagonist

1971 ◽  
Vol 3 (4) ◽  
pp. 204-208 ◽  
Author(s):  
H. J. Gilfrich ◽  
K. H. Rahn ◽  
R. F. Nicolescu
Keyword(s):  
Haemodynamic Effects ◽  
Beta Adrenergic ◽  
Adrenergic Antagonist ◽  
Blocking Activity ◽  
Adrenergic Blocking ◽  
Beta Adrenergic Antagonist

Mediation of isoproterenol-induced thirst in rats by β2-adrenergic receptors

1978 ◽  
Vol 56 (3) ◽  
pp. 465-470 ◽  
Author(s):  
M. J. Katovich ◽  
M. J. Fregly
Keyword(s):  
Water Intake ◽  
Adrenergic Receptors ◽  
Subcutaneous Administration ◽  
Female Rats ◽  
Acute Administration ◽  
Drinking Response ◽  
Adrenergic Antagonist ◽  
Blocking Activity ◽  
Β Adrenergic Receptors ◽  
Adrenergic Blocking

Isoproterenol-induced thirst in rats has been attributed to the activation of β-adrenergic receptors. Since these receptors can be further differentiated pharmacologically into β1 and β2 types, experiments were performed using several β-adrenergic agonists and antagonists to determine the receptor type initiating the isoproterenol-induced thirst. The β1- and β2-adrenergic antagonist, d,l-propranolol (1 mg/kg, ip), blocked the increase in water intake usually accompanying acute subcutaneous administration of isoproterenol (25 μg/kg) to female rats. Since l-propranolol is known to stabilize membranes and to possess anesthetic-like properties, d-propranolol was also used. This isomer has little β-adrenergic-blocking activity but possesses anesthetic-like activity. Administration of d-propranolol (1 mg/kg, ip) failed to affect the drinking response to acute administration of isoproterenol (25 μg/kg). Practolol (125 mg/kg), a β1-adrenergic antagonist with little anesthetic properties, also had no effect on water intake of isoproterenol-treated rats. Butoxamine, a selective β2-adrenergic antagonist, attenuated the drinking response to isoproterenol. Salbutamol (150 μg/kg), a β2-adrenergic agonist, mimicked the effect of isoproterenol on water intake. These results are consistent with the suggestion that β2-adrenergic receptors mediate the isoproterenol-induced thirst in rats.

ChemInform Abstract: BETA-ADRENERGIC BLOCKING ACTIVITY OF BENZO-BICYCLIC DERIVATIVES, A SEARCH FOR CARDIAC SELECTIVITY

1975 ◽  
Vol 6 (10) ◽  
pp. no-no
Author(s):  
VITTORIO VECCHIETTI ◽  
FRANCESCO LAURIA ◽  
RAFFAELE TOMMASINI ◽  
MARIO BERGAMASCHI
Keyword(s):  
Beta Adrenergic ◽  
Blocking Activity ◽  
Adrenergic Blocking

.beta.1-Selective adrenoceptor antagonists. 1. Synthesis and .beta.-adrenergic blocking activity of a series of binary (aryloxy)propanolamines

1983 ◽  
Vol 26 (11) ◽  
pp. 1561-1569 ◽  
Author(s):  
R. W. Kierstead ◽  
A. Faraone ◽  
F. Mennona ◽  
J. Mullin ◽  
R. W. Guthrie ◽  
...  
Keyword(s):  
Beta Adrenergic ◽  
Blocking Activity ◽  
Adrenergic Blocking

Beta-Adrenergic–Antagonist Drugs in the Prevention of Gastrointestinal Bleeding in Patients with Cirrhosis and Esophageal Varices

1991 ◽  
Vol 324 (22) ◽  
pp. 1532-1538 ◽  
Author(s):  
Thierry Poynard ◽  
Paul Calès ◽  
Linda Pasta ◽  
Gaetano Ideo ◽  
Jean-Pierre Pascal ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Esophageal Varices ◽  
Beta Adrenergic ◽  
Adrenergic Antagonist ◽  
Beta Adrenergic Antagonist

Beta-adrenergic antagonist propranolol inhibits mammalian cell lysosome spreading and invasion by Trypanosoma cruzi metacyclic forms

2017 ◽  
Vol 19 (4-5) ◽  
pp. 295-301 ◽  
Author(s):  
Silene Macedo ◽  
João Paulo Ferreira Rodrigues ◽  
Sergio Schenkman ◽  
Nobuko Yoshida
Keyword(s):  
Trypanosoma Cruzi ◽  
Mammalian Cell ◽  
Beta Adrenergic ◽  
Adrenergic Antagonist ◽  
Beta Adrenergic Antagonist
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