Physiologically active papaverine derivatives

1972 ◽  
Vol 8 (1) ◽  
pp. 77-78
Author(s):  
K. T. Poroshin ◽  
Yu. D. Sadykov ◽  
K. Kh. Khaidarov ◽  
A. L. Vovsi-Kol'shtein ◽  
V. A. Degtyarev ◽  
...  
Keyword(s):  
Papaverine Derivatives

scholarly journals Syntheses of Papaverine Derivatives. I

1951 ◽  
Vol 71 (5) ◽  
pp. 322-324
Author(s):  
Tetsuji Kametani
Keyword(s):  
Papaverine Derivatives

ChemInform Abstract: Synthetic Potential of Papaverine Derivatives via Benzynes.

ChemInform ◽  
1987 ◽  
Vol 18 (35) ◽  
Author(s):  
A. RODRIGUEZ DE LERA ◽  
S. AUBOURG ◽  
R. SUAU ◽  
L. CASTEDO
Keyword(s):  
Papaverine Derivatives

Bioactive papaverine derivatives bind G-quadruplexes selectively

2012 ◽  
Vol 66 (2) ◽  
Author(s):  
Elzbieta Galezowska ◽  
Joanna Kosman ◽  
Agnieszka Stepien ◽  
Blazej Rubis ◽  
Maria Rybczynska ◽  
...  
Keyword(s):  
Equilibrium Dialysis ◽  
Oxidation Products ◽  
Telomeric Sequence ◽  
Telomeric Dna ◽  
Binding Selectivity ◽  
Anti Cancer ◽  
G Quadruplex ◽  
Chloride Ligand ◽  
Papaverine Derivatives ◽  
Dna Secondary Structures

AbstractG-quadruplexes are a family of DNA secondary structures resulting from the folding of a guanine-rich sequence. Targeting quadruplexes by small molecules is an approach that is currently being studied with the aim of exploring their biological roles and developing new anti-cancer agents. There is evidence that the formation of G4 structures by telomeric DNA can be used to inhibit the enzyme activity of telomerase, and thereby to activate the pathway to senescence in tumour cells. It was previously shown that the papaverine oxidation products 6a,12a-diazadibenzo-[a,g]fluorenylium derivative (ligand I) and 2,3,9,10-tetramethoxy-12-oxo-12H-indolo[2,1-a]isoquinolinium chloride (ligand II) bind to G-quadruplex representing the human telomeric sequence. These ligands possess the ability to inhibit telomerase and polymerase action at the micromolar level. Here we report a DNA binding study on these two ligands and a new derivative 2-(2-carboxy-4,5-dimethoxyphenyl0-6,7-dimethoxyisoquiloliniuminner salt (ligand III) in order to evaluate their binding selectivity to samples of nucleic acids (ssDNA, dsDNA, triplexes, and quadruplexes). Simultaneous investigations on several DNA-ligand complexes carried out using an equilibrium dialysis approach revealed pronounced binding selectivity of ligand I and ligand II to tetraplex DNA structures over the doublestranded DNA forms.

Some papaverine derivatives

1984 ◽  
Vol 20 (4) ◽  
pp. 472-474
Author(s):  
V. A. Degtyarev ◽  
Yu. D. Sadykov ◽  
M. Kurbanov ◽  
V. S. Aksenov
Keyword(s):  
Papaverine Derivatives

Synthetic Potential of Papaverine Derivatives via Benzynes

Heterocycles ◽  
1987 ◽  
Vol 26 (3) ◽  
pp. 675 ◽  
Author(s):  
Rafael Suau ◽  
Angel Rodriguez de Lera ◽  
Santiago Aubourg ◽  
Luis Castedo
Keyword(s):  
Papaverine Derivatives

377 POSTER Papaverine derivatives – new telomerase inhibitors

2007 ◽  
Vol 5 (4) ◽  
pp. 77-78
Author(s):  
B. Rubis ◽  
B. Juskowiak ◽  
T. Hermann ◽  
E. Galezowska ◽  
A. Czyrski ◽  
...  
Keyword(s):  
Telomerase Inhibitors ◽  
Papaverine Derivatives

Biosynthesis of Unnatural Papaverine Derivatives in Papaver somniferum

1980 ◽  
Vol 43 (6) ◽  
pp. 736-738 ◽  
Author(s):  
E. Brochmann-Hanssen ◽  
C-Y. Chen ◽  
E. E. Linn
Keyword(s):  
Papaver Somniferum ◽  
Papaverine Derivatives
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