Repin, a new sesquiterpene lactone fromAcroptilon repens

1966 ◽  
Vol 2 (4) ◽  
pp. 235-236 ◽  
Author(s):  
R. I. Evtratova ◽  
R. Ya. Rzazade ◽  
K. S. Rybalko
Keyword(s):  
Sesquiterpene Lactone

Phytochemistry, Traditional Uses and Pharmacological properties of Enhydra fluctuans Lour: A Comprehensive Review.

2020 ◽  
Vol 21 ◽  
Author(s):  
Antica Barua ◽  
Muhammad Shaiful Alam ◽  
Md. Junaid ◽  
Yeasmin Akter ◽  
Syeda Samira Afrose ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Chemical Constituents ◽  
Phytochemical Analysis ◽  
Microbial Infection ◽  
Scientific Databases ◽  
Traditional Uses ◽  
Cns Depressant ◽  
Isoflavone Glycoside ◽  
Online Library ◽  
Pharmacologically Active

Background: Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or harkuch, belonging to family Asteraceae, and is an edible semi-aquatic herbaceous vegetable plant with serrate leaves, grows commonly in different parts of the world. Enhydra fluctuans possesses potential pharmacological role against inflammation, cancer, diarrhea, microbial infection, diabetes, and so on. Aim of the review: This review aims to provide the most current information on the botanical characterization, distribution, traditional uses, chemical constituents, as well as the pharmacological activities of Enhydra fluctuans Lour. Materials and methods: The recently updated information on Enhydra fluctuans was gathered from scientific journals, books, and worldwide accepted scientific databases via a library and electronic search (PubMed, Elsevier, Google Scholar, Springer, Scopus, Web of Science, Wiley online library. All of the full-text articles and abstracts related to Enhydra were screened. The most important and relevant articles were carefully chosen for study in this review. Results: Crude extracts and isolated compounds of Enhydra fluctuans Lour has been reported pharmacologically active against cytoprotective, analgesic and anti-inflammatory, antimicrobial, anticancer, anti-diarrhoeal, antihelmintic, CNS depressant, hepatoprotective, thrombolytic, antidiabetic, anti-oxidant, phagocytic and cytotoxic, and neuroprotective potential activities. Discussion: Phytochemical analysis from different studies has reported Germacranolide, Sesquiterpene lactone, Flavonoid, Essential oil, Steroid, Diterpenoid, Melampolide, Sesquiterpene lactone, Isoflavone glycoside as major compounds of Enhydra fluctuans Lour. Conclusions: However, more research is important to explore the mode of action of bioactive components of the plant and its therapeutic capabilities.

Anticancer Potential of Aguerin B, a Sesquiterpene Lactone Isolated from Centaurea behen in Metastatic Breast Cancer Cells

2020 ◽  
Vol 15 (2) ◽  
pp. 165-173
Author(s):  
Elaheh Amini ◽  
Mohammad Nabiuni ◽  
Seyed Bahram Behzad ◽  
Danial Seyfi ◽  
Farhad Eisvand ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Tumor Cell ◽  
Sesquiterpene Lactone ◽  
Sesquiterpene Lactones ◽  
Metastatic Breast ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Skin Malignancy

Background: Breast carcinoma is a malignant disease that represents the most common non-skin malignancy and a chief reason of cancer death in women. Large interest is growing in the use of natural products for cancer treatment, especially with goal of suppression angiogenesis, tumor cell growth, motility, as well as invasion and metastasis with low/no toxicity. It is evident from recent patents on the anticancer properties of sesquiterpene lactones such as parthenolide. Objective: In this study, using MDA-MB-231 cells of a human breast adenocarcinoma, the effects of aguerin B, as a natural sesquiterpene lactone, has been evaluated, in terms of the expression of metastatic-related genes (Pak-1, Rac-1 and HIF-1α). Methods: Cytotoxicity of aguerin B was tested toward MDA-MB-231 breast tumor cells using MTT. Scratch assay was accomplished to evaluate the tumor cell invasion. To understand the underlying molecular basis, the mRNA expressions were evaluated by real time PCR. Results: It was found that aguerin B significantly inhibited human breast cancer cell growth in vitro (IC50 = 2μg/mL) and this effect was accompanied with a persuasive suppression on metastasis. Our results showed that aguerin B in IC50 concentration down-regulated Rac-1, Pak-1, Hif-1α and Zeb-1 transcriptional levels. Conclusion: Taken together, this study demonstrated that aguerin B possessed potential anti-metastatic effect, suggesting that it may consider as a potential multi target bio compound for treatment of breast metastatic carcinoma.

Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

2019 ◽  
Vol 245 ◽  
pp. 112186 ◽  
Author(s):  
R. Sabel ◽  
A.S. Fronza ◽  
L.Z.B. Carrenho ◽  
A. Maes ◽  
M.L. Barros ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa

2021 ◽  
Vol 59 (1) ◽  
pp. 943-954
Author(s):  
Perwez Alam ◽  
Rama Tyagi ◽  
Mohammad Abul Farah ◽  
Md. Tabish Rehman ◽  
Afzal Hussain ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Sesquiterpene Lactone ◽  
Docking Analysis ◽  
Inula Racemosa ◽  
Molecular Docking Analysis

Variation of sesquiterpene lactone contents in Lactuca georgica natural populations from Armenia

2014 ◽  
Vol 62 (3) ◽  
pp. 431-441 ◽  
Author(s):  
Alex Beharav ◽  
Anna Stojakowska ◽  
Roi Ben-David ◽  
Janusz Malarz ◽  
Klaudia Michalska ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Natural Populations

7-Hydroxy Frullanolide, a sesquiterpene lactone, increases intracellular calcium amounts, lowers CD4+ T cell and macrophage responses, and ameliorates DSS-induced colitis

2021 ◽  
Vol 97 ◽  
pp. 107655
Author(s):  
Sanmoy Pathak ◽  
Abhijeet Gokhroo ◽  
Ashim Kumar Dubey ◽  
Shamik Majumdar ◽  
Souradeep Gupta ◽  
...  
Keyword(s):  
T Cell ◽  
Intracellular Calcium ◽  
Sesquiterpene Lactone ◽  
Cd4 T Cell

Ambrosin — A sesquiterpene lactone fromCyclachaena xanthifolia

1968 ◽  
Vol 4 (6) ◽  
pp. 327-328 ◽  
Author(s):  
V. I. Novikov ◽  
Yu. N. Forostyan ◽  
D. P. Popa
Keyword(s):  
Sesquiterpene Lactone
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