A controlled study of the antihypertensive effect of carteolol, a new?-adrenergic receptor blocking drug, in combination with hydrochlorthiazide and amiloride

1981 ◽  
Vol 19 (4) ◽  
pp. 239-244 ◽  
Author(s):  
A. Tarkiainen ◽  
K. Saraste ◽  
T. Sepp�l� ◽  
A. Gordin ◽  
J. Auvinen
Keyword(s):  
Adrenergic Receptor ◽  
Antihypertensive Effect ◽  
Controlled Study ◽  
Blocking Drug ◽  
Receptor Blocking

The Influence of Adrenergic Receptor Blocking Agents on the Mouse Thyroid

1970 ◽  
Vol 39 (6) ◽  
pp. 781-791 ◽  
Author(s):  
Pat Kendall-Taylor ◽  
D. S. Munro
Keyword(s):  
Adrenergic Receptor ◽  
Adenosine Monophosphate ◽  
Thyroid Stimulating Hormone ◽  
Adrenergic Blockade ◽  
Blocking Drug ◽  
Receptor Blocking ◽  
Long Acting ◽  
Adrenergic Blocking ◽  
Mouse Thyroid

1. The influence of adrenergic receptor blocking drugs on the mouse thyroid gland maintained in vitro has been investigated. 2. Phentolamine, an α adrenergic blocking drug, and propranolol, a β blocking drug, inhibited the release of [131I]iodothyronines from pre-labelled mouse thyroids, which otherwise occurred when the glands were incubated in the presence of thyroid stimulating hormone, long acting thyroid stimulator, or cyclic 3′5′-adenosine monophosphate. 3. Evidence is presented to show that (a) the inhibition is not due to adrenergic blockade, (b) the effect cannot wholly be attributed to the prevention of adenyl cyclase activation, (c) the mechanism of action of the two drugs is dissimilar. 4. The observed clinical response in the treatment of thyrotoxicosis does not appear to be related to this antithyroid effect of propranolol.

ACCUMULATION OF ALPRENOLOL IN SOME POLYPEPTIDE HORMONE PRODUCING CELLS AND IN MELANIN-CONTAINING TISSUES

1975 ◽  
Vol 79 (1) ◽  
pp. 202-208 ◽  
Author(s):  
Premysl Slanina ◽  
Hans Tjälve
Keyword(s):  
Characteristic Feature ◽  
Pituitary Gland ◽  
Distribution Pattern ◽  
Pancreatic Islets ◽  
Adrenergic Receptor ◽  
Endocrine Cells ◽  
Whole Body ◽  
Blocking Drug ◽  
High Accumulation ◽  
Receptor Blocking

ABSTRACT The distribution of the β-adrenergic-receptor blocking drug alprenolol labelled with 3H was studied in mice by whole body autoradiography. The most characteristic feature in the distribution pattern was the accumulation in endocrine cells within the pancreatic islets, the adrenal medulla, the pituitary gland and some cells of the thyroid, presumably representing the parafollicular cells. A high accumulation was also observed in melanin-containing tissues.

scholarly journals MODULATORY ANTI- DIARRHEAL EFFECTS OF ASCORBIC ACID IN SWISS ALBINO MICE

2021 ◽  
Vol 18 (1) ◽  
pp. 9-17
Keyword(s):  
Ascorbic Acid ◽  
Adrenergic Receptor ◽  
Castor Oil ◽  
Docking Study ◽  
Binding Affinities ◽  
Molecular Docking Study ◽  
Receptor Blocking ◽  
Swiss Mice ◽  
Mixed Groups ◽  
The Impact

Ascorbic acid (AA) has been reported for the management of diarrhea. The anti-diarrheal potential and modulatory activities of AA on some commonly used anti-diarrheal drugs were investigated. For this purpose, the activities of AA on castor oil-induced diarrhea in Swiss mice were examined. As standard anti-diarrheal agents, we used prazosin, propranolol, loperamide, and nifedipine with or without AA. The results revealed that AA at 25 mg/kg (i.p.) and all other standard drugs exhibited significant (p < 0.05) diarrheal attenuating activities in mice. However, the impact was more pronounced in the loperamide and propranolol groups. AA administrated with prazosin and propranolol had a higher rate of latent periods and a lower rate of diarrheic secretion during the study period (4 h) than that of the other single or mixed groups. Furthermore, a molecular docking study illustrated that AA displayed good binding affinities with (α1) (–5.2 Kcal/mol), α2b (–5.4 Kcal/mol), α2c (-5.6 Kcal/mol), β1(–5.3 Kcal/mol) and β2(–6.4 Kcal/mol) adrenoceptors. Of note, AA exerted a significant anti-diarrheal effect and it was seen to modulate the anti-diarrheal effects of α- and β-adrenergic receptor blocking agents in Swiss mice.

Sign in / Sign up

Export Citation Format

Share Document