The influence of hypoglycaemic sulphonylureas on elimination and efficacy of phenprocoumon following a single oral dose in diabetic patients

1976 ◽  
Vol 10 (1) ◽  
pp. 31-36 ◽  
Author(s):  
P. Heine ◽  
H. Kewitz ◽  
K. -A. Wiegboldt
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Diabetic Patients ◽  
Hypoglycaemic Sulphonylureas

scholarly journals Effect of dihydro-artemisinin on the pharmacokinetics of gliclazide in diabetic subjects

2020 ◽  
Vol 14 (6) ◽  
pp. 2267-2276
Author(s):  
Sambo Godwin Ishaku ◽  
Mojirade Taibat Bakare-Odunola ◽  
Aminu Musa ◽  
Ibrahim Adamu Yakasai ◽  
Magaji Garba ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Phase 1 ◽  
Pharmacokinetic Parameters ◽  
Diabetic Patients ◽  
Tropical Regions

Diabetic patients do have co-occurring diseases like malaria, especially in tropical regions. Hence, polypharmacy is sometimes unavoidable. Gliclazide is widely used in the treatment of non-insulin-dependent type 2 diabetes mellitus, while dihydro-artemisinin (DHA) is one of the most promising medications used in the treatment of malaria on account of its good efficacy and tolerability. The study evaluated the effect of DHA on the pharmacokinetics of gliclazide in diabetic patients. This is a single dose one-way, cross-over study in two periods, with each phase preceded by an overnight fast. Six subjects that passed inclusion criteria participated in the study. The volunteers acted as their control. Phase 1 of the study involved administering a single oral dose of 80 mg of gliclazide after an overnight fast. After a washout period of one week, 80 mg gliclazide and 120 mg DHA were co-administered. Serial blood samples were collected at time intervals throughout 24 h and processed. A validated HPLC method was used to estimate serum gliclazide concentration, while the glucose oxidase peroxidase method was used in the evaluation of blood glucose concentration. The Pharmacokinetic Software - PharmPK was used to generate the pharmacokinetic parameters. GraphPad Prism version 7.01 software for window was used for data analysis. Statistical differences observed in the pharmacokinetic profiles of gliclazide and blood glucose concentration were not significant. Single oral dose of gliclazide and dihydro-artemisinin had good safety and tolerability in diabetic subjects. Keywords: Diabetes mellitus, Dihydro-artemisinin, Drug Interactions, Gliclazide, Pharmacokinetics  

A Rapid (48 hours) Thyroid Suppression Test using a Single Oral Dose of 100 of Triiodothyronine

1973 ◽  
Vol 12 (03) ◽  
pp. 218-224
Author(s):  
Elli Lakka - Papadodima ◽  
Constantin Ntalles ◽  
Denis Ikkos
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Suppression Test

Des mesurages répétés de la fixation thyroïdienne de 10 minutes du 132I injecté intraveineusement on été effectués sur 55 malades euthyroïdiens sans et avec goitre et sur 16 malades hyperthyreoïdiens par 4 jours consécutifs. Immédiatement après le premier mesurage tous les malades recevaient une dose unique oral de 100 μg de Triiodothyronine (T3). Les valeurs de fixation 24, 48 et 72 heures après le T3 (moyen ± déviation standard) étaient de 75 ± 1,7, 64 ± 1,8, et 67 ± 1,9 dans le groupe euthyroïdien et le 106 ± 2,6, 104 ± 2,2 et 108 ± 4,0 dans le groupe hyperthyroïdien, exprimés en pourcentage du groupe controle. 48 heures après T3 tous les personnes euthyroïdiens, sauf une, avaient des valeurs en dessous de 88% tandis que la valeur la plus basse des personnes hyperthyroïdiens ce jour était de 93%. La séparation des valeurs 48 heures des deux groupes était complète après avoir respecté l’influence de la première fixation sur la valeur 48 heures. On peut donc supposer q’un test thyroïdien de suppression utilisable en clinique peut-être effectué en 48 heures après une administration oral de 100 μg de T3 et mesurage de la fixation 10 minutes après l’injection du radioisotope.

Effect of Aspirin on the Thrombelastogram of Human Blood

1973 ◽  
Vol 30 (03) ◽  
pp. 494-498 ◽  
Author(s):  
G de Gaetano ◽  
J Vermylen
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Platelet Function ◽  
Human Blood ◽  
Platelet Rich Plasma ◽  
Plasma Samples ◽  
Release Reaction ◽  
Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

Serum Enzyme, Corticosterone and Tissue Changes in Rats Following a Single Oral Dose of Ethanol

1970 ◽  
Vol 31 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Paul D. Altland ◽  
Benjamin Highman ◽  
Milton G. Parker ◽  
Michael P. Dieter
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Serum Enzyme ◽  
Tissue Changes

Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women

1983 ◽  
Vol 103 (3) ◽  
pp. 309-314 ◽  
Author(s):  
G. Rosadini ◽  
P. Masturzo ◽  
G. Rodriguez ◽  
G. Murialdo ◽  
V. Montano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Power Analysis ◽  
Sleep Pattern ◽  
Absolute Power ◽  
Normal Women

Abstract. The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.

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