Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes

1978 ◽  
Vol 14 (4) ◽  
pp. 281-291 ◽  
Author(s):  
G. Leopold ◽  
W. Ungeth�m ◽  
E. Groll ◽  
H. W. Diekmann ◽  
H. Nowak ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Normal Volunteers ◽  
New Drug

Clinical Pharmacology of Tolmetin: Comparisons in Rheumatoid Arthritis Patients and Normal Volunteers

1983 ◽  
Vol 23 (7) ◽  
pp. 329-335 ◽  
Author(s):  
DANIEL E. FURST ◽  
SYDNEY H. DROMGOOLE ◽  
RAVI K. DESIRAJU ◽  
HAROLD E. PAULUS
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Pharmacology ◽  
Normal Volunteers

Chronic Cannabis Users: A New Special Population to Consider for Drug Development

2021 ◽  
Vol 16 ◽  
Author(s):  
Gina Pastino ◽  
Diana Shuster
Keyword(s):  
Clinical Pharmacology ◽  
Drug Development ◽  
Cannabis User ◽  
Special Population ◽  
Safety And Efficacy ◽  
New Drug ◽  
Metabolic Interactions ◽  
Widespread Availability ◽  
Baseline Characteristics ◽  
Efficacy Profile

The use and acceptance of cannabis, either medically or recreationally, has substantially outpaced the collection of data necessary to evaluate its use in any population. However, the mere widespread availability does not imply the absence of risk or confirmation of efficacy and should not be treated as such. There is enough data to suggest that not only does the potential for pharmacokinetic and metabolic interactions exist, but also that baseline characteristics for a given population could be different in chronic cannabis users. Either or both of these may impact the safety and efficacy profile for any new drug in development. As such, we encourage drug developers to consider that the cannabis user may very well be a special population that warrants its own clinical pharmacology evaluation.

Overview of recently approved 505(b)(2) new drug applications (2010-2012): Role of clinical pharmacology

2014 ◽  
Vol 54 (12) ◽  
pp. 1330-1336 ◽  
Author(s):  
Sheetal Agarwal ◽  
Wei Qiu ◽  
Chandrahas Sahajwalla
Keyword(s):  
Clinical Pharmacology ◽  
New Drug

Clinical pharmacology of carvedilol in normal volunteers

1987 ◽  
Vol 41 (1) ◽  
pp. 31-44 ◽  
Author(s):  
Luigi X Cubeddu ◽  
Nery Fuenmayor ◽  
France Varin ◽  
Victor G Villagra ◽  
Romulo E Colindres ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Normal Volunteers

scholarly journals Biotherapeutics and its applications in Microbiology

2021 ◽  
Vol 22 (SE) ◽  
pp. 63-78
Author(s):  
Navjot Kaur ◽  
Vishu Chaudhary
Keyword(s):  
Clinical Pharmacology ◽  
Monoclonal Antibodies ◽  
Pharmaceutical Industry ◽  
Major Part ◽  
Pharmaceutical Market ◽  
Assembly Process ◽  
New Drug ◽  
Pharmacology And Toxicology ◽  
Organic Source ◽  
The Way

Biotherapeutics is a rapidly growing segment of the entire pharmaceutical industry that constitutes approximately one-quarter of ongoing new drug endorsements. Monoclonal antibodies are a major part of these endorsements every year (mAbs). MAbs' non-clinical pharmacology and toxicology research compare with substance components during progression, since these biotherapeutics are extracted from an organic source, and to inspire a pharmacological reaction, the creature models must also have similar epitopes (focuses) as individuals. Biotherapeutic items (BTPs) are the quickest developing drugs in the pharmaceutical market. Despite their clinical achievement, the immunogenicity of BTPs keeps on being a significant concern. The subcutaneous (SC) course is to cultivate a passion for the organisation of biotherapeutics. Both monoclonal antibodies and various biotherapeutics are discussed. Medicine has been disrupted by biotherapeutic drugs (BPs), altering the way we treat a few processes. Comparative BPs (SBPs) are discussed here, also called biosimilars, including the assembly process and administrative viewpoints used. Monoclonal antibodies can apply synergistic antitumour impacts in blend with other immunomodulatory approaches, for example, chemotherapy, radiotherapy, directed treatment specialists, immunisations, or different immunomodulators. Probiotics have gotten profoundly perceived as enhancements for people and specifically for creatures given their gainful result on wellbeing improvement and prosperity support.

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