Gating currents of inactivating and non-inactivating potassium channels expressed in Xenopus oocytes

1991 ◽  
Vol 418 (4) ◽  
pp. 423-429 ◽  
Author(s):  
Walter St�hmer ◽  
Franco Conti ◽  
Martin Stocker ◽  
Olaf Pongs ◽  
Stefan H. Heinemann
Keyword(s):  
Potassium Channels ◽  
Xenopus Oocytes ◽  
Gating Currents

Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes

2000 ◽  
Vol 362 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Sascha Rolf ◽  
Wilhelm Haverkamp ◽  
Martin Borggrefe ◽  
Ulrich Mußhoff ◽  
Lars Eckardt ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Xenopus Oocytes ◽  
Antiarrhythmic Drugs ◽  
Voltage Gated

scholarly journals Function of Shaker Potassium Channels Produced by Cell-Free Translation Upon Injection into Xenopus Oocytes

2013 ◽  
Vol 104 (2) ◽  
pp. 197a
Author(s):  
Brian W. Jarecki ◽  
Shin-ichi Makino ◽  
Emily T. Beebe ◽  
Brian G. Fox ◽  
Baron Chanda
Keyword(s):  
Potassium Channels ◽  
Xenopus Oocytes ◽  
Free Translation ◽  
Shaker Potassium Channels

scholarly journals Dihydropyridine Action on Voltage-dependent Potassium Channels Expressed in Xenopus Oocytes

1997 ◽  
Vol 109 (2) ◽  
pp. 169-180 ◽  
Author(s):  
Vladimir Avdonin ◽  
Erwin F. Shibata ◽  
Toshinori Hoshi
Keyword(s):  
Ion Channels ◽  
Potassium Channels ◽  
Xenopus Oocytes ◽  
K Channels ◽  
Open Time ◽  
Voltage Dependent ◽  
Ca2 Channels

Dihydropyridines (DHPs) are well known for their effects on L-type voltage-dependent Ca2+ channels. However, these drugs also affect other voltage-dependent ion channels, including Shaker K+ channels. We examined the effects of DHPs on the Shaker K+ channels expressed in Xenopus oocytes. Intracellular applications of DHPs quickly and reversibly induced apparent inactivation in the Shaker K+ mutant channels with disrupted N- and C-type inactivation. We found that DHPs interact with the open state of the channel as evidenced by the decreased mean open time. The DHPs effects are voltage-dependent, becoming more effective with hyperpolarization. A model which involves binding of two DHP molecules to the channel is consistent with the results obtained in our experiments.

scholarly journals Function of Shaker potassium channels produced by cell-free translation upon injection into Xenopus oocytes

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Brian W. Jarecki ◽  
Shin-ichi Makino ◽  
Emily T. Beebe ◽  
Brian G. Fox ◽  
Baron Chanda
Keyword(s):  
Potassium Channels ◽  
Xenopus Oocytes ◽  
Free Translation ◽  
Shaker Potassium Channels
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