Acute and long-term hypotensive effects and plasma concentrations of nifedipine in patients with essential hypertension

1982 ◽  
Vol 23 (3) ◽  
pp. 197-201 ◽  
Author(s):  
K. Aoki ◽  
K. Sato ◽  
Y. Kawaguchi ◽  
M. Yamamoto
Keyword(s):  
Essential Hypertension ◽  
Plasma Concentrations

Reduced Plasma Concentrations of Nitrogen Oxide in Individuals With Essential Hypertension

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 405-408 ◽  
Author(s):  
Koichi Node ◽  
Masafumi Kitakaze ◽  
Hiromichi Yoshikawa ◽  
Hiroaki Kosaka ◽  
Masatsugu Hori
Keyword(s):  
Essential Hypertension ◽  
Nitrogen Oxide ◽  
Plasma Concentrations

scholarly journals Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity

2018 ◽  
Vol 315 (1) ◽  
pp. E91-E98 ◽  
Author(s):  
S. R. Coutinho ◽  
J. F. Rehfeld ◽  
J. J. Holst ◽  
B. Kulseng ◽  
C. Martins
Keyword(s):  
Weight Loss ◽  
Severe Obesity ◽  
Peptide Yy ◽  
Plasma Concentrations ◽  
Cardiovascular Fitness ◽  
Ghrelin Concentration ◽  
Time Points ◽  
Diet And Exercise ◽  
The Impact

The impact of lifestyle-induced weight loss (WL) on appetite in patients with obesity remains controversial. This study aimed to assess the short- and long-term impact of WL achieved by diet and exercise on appetite in patients with obesity. Thirty-five (22 females) adults with severe obesity (body mass index: 42.5 ± 5.0 kg/m2) underwent a 2-yr WL program focusing on diet and exercise. Body weight (BW), cardiovascular fitness (V̇o2max), appetite feelings, and plasma concentrations of insulin, active ghrelin (AG), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and cholecystokinin (CCK), in the fasting and postprandial states, were measured at baseline (B), week 4 (W4), and 1 and 2 yr (and average values for all fasting and postprandial time points computed). BW was significantly reduced and V̇o2max(ml·kg−1·min−1) increased at all time points compared with B (3.5, 8.1, and 8.4% WL and 7, 11, and 8% increase at W4 and 1 and 2 yr, respectively). Basal hunger and average hunger and desire to eat were significantly increased at 1 and 2 yr. Basal fullness was significantly increased at W4, and average ratings were reduced at 1 yr. Average AG and PYY were significantly increased, and insulin was reduced, at all time points compared with B. Average GLP-1 was reduced at W4, and CCK was increased at 2 yr. After lifestyle-induced WL, patients with severe obesity will, therefore, have to deal with increased hunger in the long term. In conclusion, sustained WL at 2 yr achieved with diet and exercise is associated with increased hunger feelings and ghrelin concentration but also increased postprandial concentrations of satiety hormones.

scholarly journals Long-term experience of captopril in the treatment of primary (essential) hypertension.

1982 ◽  
Vol 14 (S2) ◽  
pp. 133S-137S ◽  
Author(s):  
BE Karlberg ◽  
J Asplund ◽  
S Wettre ◽  
KP Ohman ◽  
OR Nilsson
Keyword(s):  
Essential Hypertension ◽  
Long Term Experience

scholarly journals Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Rosa Casas ◽  
Mireia Urpi-Sardà ◽  
Emilio Sacanella ◽  
Sara Arranz ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Plasma Concentrations ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Inflammatory Biomarkers ◽  
Elderly Persons ◽  
Long Term Effects ◽  
Plaque Development ◽  
Atheroma Plaque

Objective.To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease.Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®.Results.At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β(P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group.Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

ABPM Comparison of the Anti-Hypertensive Profiles of Telmisartan and Enalapril in Patients with Mild-to-Moderate Essential Hypertension

2002 ◽  
Vol 30 (6) ◽  
pp. 543-552 ◽  
Author(s):  
J Amerena ◽  
S Pappas ◽  
J-P Ouellet ◽  
L Williams ◽  
D O'Shaughnessy
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Monitoring ◽  
Study Drug ◽  
Pressure Control ◽  
Moderate Essential Hypertension ◽  
Open Label ◽  
Night Time ◽  
Once Daily

In this multicentre, prospective, randomized, open-label, blinded-endpoint (PROBE) study, the efficacy of 12 weeks' treatment with once-daily telmisartan 40–80 mg and enalapril 10–20 mg was evaluated using ambulatory blood pressure monitoring (ABPM) in 522 patients with mild-to-moderate essential hypertension. Patients were titrated to the higher dose of study drug at week 6 if mean seated diastolic blood pressure (DBP) was ≥ 90 mmHg. The primary endpoint was the change from baseline in ambulatory DBP in the last 6 h of the 24-h dosing interval after 12 weeks' treatment. Telmisartan and enalapril produced similar reductions from baseline in DBP and systolic blood pressure (SBP) over all ABPM periods evaluated (last 6 h, 24-h, daytime and night-time). Telmisartan produced a significantly greater reduction in mean seated trough DBP, measured unblinded with an automated ABPM device in the clinic, amounting to a difference of −2.02 mmHg ( P < 0.01). A significantly greater proportion of patients achieved a seated diastolic response with telmisartan than enalapril (59% versus 50%; P < 0.05), also measured with the same ABPM device. Both treatments were well tolerated. Compared with telmisartan, enalapril was associated with a higher incidence of cough (8.9% versus 0.8%) and hypotension (3.9% versus 1.1%). Therefore, telmisartan may provide better long-term compliance and, consequently, better blood pressure control than enalapril.

An Unsuccessful Attempt to Treat Hypertension with Acupuncture

1977 ◽  
Vol 05 (01) ◽  
pp. 39-44 ◽  
Author(s):  
K. Sugioka ◽  
W. Mao ◽  
J. Woods ◽  
R. A. Mueller
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Acupuncture Treatment ◽  
Plasma Catecholamines ◽  
Systemic Blood Pressure ◽  
Patient Acceptance ◽  
Unsuccessful Attempt ◽  
Poor Patient ◽  
Beneficial Response

The effectiveness of 5 sets of acupuncture loci in decreasing systemic blood pressure was compared with chlorthalidone and propranolol in patients with essential hypertension. No statistically significant acute or long-term changes in plasma catecholamines, renin activity, or blood pressure and pulse rate were observed as a result of acupuncture treatment. The decrease in blood pressure was significantly less than the observed with propranolol, but not significantly less than produced by chlorthalidone. Because of the poor patient acceptance of acupuncture and in the absence of a beneficial response, we feel acupuncture as employed in this study is of limited value in the management of patients with essential hypertension.

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