Comparative pharmacokinetic analysis of amoxycillin using open two and three-compartment models

1982 ◽  
Vol 22 (3) ◽  
pp. 273-279 ◽  
Author(s):  
A. Dalhoff ◽  
P. Koeppe
Keyword(s):  
Pharmacokinetic Analysis ◽  
Comparative Pharmacokinetic ◽  
Compartment Models

Comparative Pharmacokinetic of Three Sulfadiazine Suspensions by Oral Administration in Chickens

2016 ◽  
Vol 8 (2) ◽  
pp. 122
Author(s):  
Zhi-Qiang Wang ◽  
Han-Song Li ◽  
Xia Xiao ◽  
Jian-Bing Wang
Keyword(s):  
Plasma Concentration ◽  
Broiler Chickens ◽  
High Performance ◽  
Area Under The Curve ◽  
Pharmacokinetic Analysis ◽  
Pharmacokinetic Parameters ◽  
Peak Time ◽  
Comparative Pharmacokinetic ◽  
Elimination Half ◽  
Maximal Plasma

<p>The chemotherapeutics, sulfadiazine (SDA) and trimethoprim (TMP), are extensively used in a variety of animal species. In this study, a pharmacokinetic analysis was performed to compare the bioequivalence of a combined SDA and TMP product against existing licensed SDA and TMP formulations in broiler chickens. Three groups of 15 birds were administered a single dose of either the test formulation or a reference oral suspension. The plasma concentration of SDA and TMP were determined by reverse-phase high performance liquid chromatography (HPLC), and the maximal plasma concentration (C<sub>max</sub>), area under the curve (AUC), the peak time (T<sub>max</sub>), mean residence time (MRT) and elimination half-life (T<sub>1/2</sub>), were calculated for SDA. The combined formulation I and II reference suspension exhibited almost identical concentration-time curves, and ANOVA analyses of the pharmacokinetic parameters identified no significant differences between the reference preparations and the test one. Furthermore the AUC and C<sub>max</sub> values of the SDA active ingredient were not significantly different. The I formulation was bioequivalent with both II and III (80-125% and 70–143%, respectively, at the 90% confidence interval). In conclusion, the combined SDA and TMP product was bioequivalent with both existing commercially available SDA suspensions and can be used interchangeably in veterinary medical practice.</p>

Pharmacokinetics and tissue distribution of a M1 muscarinic acetylcholine receptor positive allosteric potentiator, benzyl quinolone carboxylic acid

2014 ◽  
Vol 6 (8) ◽  
pp. 2672-2678 ◽  
Author(s):  
Rizwan Basha Khatwal ◽  
Anil Dubala ◽  
Jayasankar Kosaraju ◽  
Santhivardhan Chinni ◽  
Manjunatha Narayanappa ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Tissue Distribution ◽  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Rat Plasma ◽  
Pharmacokinetic Analysis ◽  
Comparative Pharmacokinetic ◽  
Visceral Organs ◽  
M1 Muscarinic Acetylcholine Receptor ◽  
M1 Muscarinic

A comparative pharmacokinetic analysis and tissue distribution of BQCA in rat plasma visceral organs.

scholarly journals Comparative pharmacokinetic analysis of the blood-brain barrier penetration of dasatinib and ponatinib in mice

2021 ◽  
pp. 1-6
Author(s):  
Karthik Ravi ◽  
Andrea Franson ◽  
Morgan J. Homan ◽  
Holly Roberts ◽  
Manjunath P. Pai ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Pharmacokinetic Analysis ◽  
Comparative Pharmacokinetic ◽  
Blood Brain ◽  
Barrier Penetration
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