Long-term effects of pinacidil in hypertensive dialysis patients

1985 ◽  
Vol 28 (4) ◽  
pp. 375-380 ◽  
Author(s):  
E. G. Breen ◽  
D. Mulhall ◽  
J. A. B. Keogh
Keyword(s):  
Long Term Effects ◽  
Dialysis Patients

Long Term Effects of Small Doses of 1,25 Dihydroxycholecalciferol in Dialysis Patients

1979 ◽  
pp. 803-806
Author(s):  
B. Hochman ◽  
V. Gura ◽  
G. Boner ◽  
A. Weiss ◽  
A. J. Olah ◽  
...  
Keyword(s):  
Long Term Effects ◽  
Dialysis Patients ◽  
Small Doses

scholarly journals Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients

2013 ◽  
Vol 25 (5) ◽  
pp. 1094-1102 ◽  
Author(s):  
Yasuhiko Ito ◽  
Masashi Mizuno ◽  
Yasuhiro Suzuki ◽  
Hirofumi Tamai ◽  
Takeyuki Hiramatsu ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Long Term Effects ◽  
Dialysis Patients

scholarly journals Nephrological aspects of surgical weight correction in morbid obesity

2018 ◽  
Vol 90 (6) ◽  
pp. 98-104
Author(s):  
I N Bobkova ◽  
S S Gussaova ◽  
E V Stavrovskaya ◽  
A V Struve
Keyword(s):  
Morbid Obesity ◽  
Weight Loss ◽  
Kidney Damage ◽  
Long Term Effects ◽  
Dialysis Patients ◽  
Leading Position ◽  
End Stage ◽  
Nephroprotective Effect

Obesity, including morbid obesity, is a growing worldwide problem. The adverse effect of obesity on the kidneys is associated with the development of comorbid conditions, such as insulin resistance (IR), metabolic syndrome (MS), diabetes mellitus (DM), arterial hypertension (AH), which are the recognized risk factors of chronic kidney disease (СKD). Obesity also causes direct kidney damage with the development of non-immune focal segmental glomerulosclerosis. The leading pathophysiological mechanisms of kidney damage in obesity are intrarenal hemodynamic disorders with the formation of hyperfiltration and damaging effects of adipokines produced by adipose tissue. Bariatric surgery (BS) has taken a leading position in the treatment of morbid obesity, demonstrating its effectiveness not only in long-term weight loss, but also in the correction of IR, MS, DM, AH. Nephroprotective effect of significant and persistent weight loss is caused by the elimination of hyperfiltration and damaging effect of adipokines. Results of the observational studies of the immediate and long-term effects of BS have demonstrated positive renal outcomes, in particular, the decrease in albuminuria/proteinuria, the improvement or stabilization of glomerular filtration rate, the delay of end-stage renal failure development; surgical correction of body weight in dialysis patients with morbid obesity lets them realize subsequent kidney transplantation. Large, randomized prospective studies with a longer follow-up are needed; analysis of the long-term renal consequences of BS in obesity patients with pre-existing renal impairment, including dialysis patients, is required; stratification of the BS risk of renal complications (acute kidney damage, nephrolithiasis, nephrocalcinosis) and effective strategy for managing these risks need to be developed.

scholarly journals Long-term effects of the iron-based phosphate binder, sucroferric oxyhydroxide, in dialysis patients

2015 ◽  
Vol 30 (6) ◽  
pp. 1037-1046 ◽  
Author(s):  
J. Floege ◽  
A. C. Covic ◽  
M. Ketteler ◽  
J. F. E. Mann ◽  
A. Rastogi ◽  
...  
Keyword(s):  
Phosphate Binder ◽  
Long Term Effects ◽  
Dialysis Patients ◽  
Iron Based

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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