Controlled, eight-hour haemodynamic study of a sustained-release formulation of isosorbide dinitrate in moderate left ventricular failure

1984 ◽  
Vol 27 (3) ◽  
pp. 259-263 ◽  
Author(s):  
O. Dubourg ◽  
P. Gueret ◽  
A. Ferrier ◽  
J. C. Farcot ◽  
M. Terdjman ◽  
...  
Keyword(s):  
Sustained Release ◽  
Isosorbide Dinitrate ◽  
Left Ventricular ◽  
Left Ventricular Failure ◽  
Ventricular Failure ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Haemodynamic Study

Correction: isordil tembids (oral sustained-release products, 30 July p 57)

1984 ◽  
Vol 22 (20) ◽  
pp. 79.1-79
Keyword(s):  
Sustained Release ◽  
Isosorbide Dinitrate ◽  
Data Sheet ◽  
Gelatin Capsule ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Gelatin Capsules ◽  
Partial Obstruction ◽  
Hard Gelatin Capsule

Ayerst’s data sheet describes this product simply as a sustained-release formulation in gelatin capsules, which misled us into thinking that the capsule was supposed to be the s/r mechanism. Ayerst have now told us that the (ordinary) hard gelatin capsule contains granules with varying numbers of film coats, so that the isosorbide dinitrate is released over a 6-hour period. We wrongly included gelatin capsules among the types of preparation likely to be held up in patients with partial obstruction: hard gelatin readily dissolves.

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