Absence of IgA nephropathy in patients with ankylosing spondylitis

1986 ◽  
Vol 6 (4) ◽  
pp. 145-149 ◽  
Author(s):  
A. J. G. Swaak ◽  
I. Frankfort ◽  
R. S. Menon ◽  
J. M. Pekelharing ◽  
O. Planten
Keyword(s):  
Ankylosing Spondylitis ◽  
Iga Nephropathy

IgA Nephropathy in a Young Female with Ankylosing Spondylitis

Rheumatology ◽  
1987 ◽  
Vol 26 (5) ◽  
pp. 396-397 ◽  
Author(s):  
E. KANTEREWICZ ◽  
R. SANMARTI ◽  
A. COLLADO ◽  
M. A. BRANCOS ◽  
A. TORRAS ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Iga Nephropathy ◽  
Young Female

scholarly journals A case of ankylosing spondylitis associated with IgA nephropathy.

1988 ◽  
Vol 77 (12) ◽  
pp. 1888-1889
Author(s):  
Yuji NAKAMURA ◽  
Hiroko UTSUNOMIYA ◽  
Keiko YOSHIMOTO ◽  
Masahiko OKADA ◽  
Shigeki SAIMA
Keyword(s):  
Ankylosing Spondylitis ◽  
Iga Nephropathy

Onset of IgA nephropathy in a patient treated with infliximab for ankylosing spondylitis

2021 ◽  
Vol 14 (1) ◽  
pp. e237713
Author(s):  
Charlotte Anne Baert ◽  
Selda Aydin ◽  
Philippe Leroy ◽  
Patrick Durez
Keyword(s):  
Renal Function ◽  
Ankylosing Spondylitis ◽  
Kidney Disease ◽  
Iga Nephropathy ◽  
Clinical Case ◽  
Urine Analysis ◽  
Immune Dysregulation ◽  
Puncture Biopsy ◽  
Necrosis Factor

We report the case of a 43-year-old man, suffering from ankylosing spondylitis and treated with Infliximab 5 mg/kg every 2 months, with an excellent disease control. During a follow-up consultation, an incipient renal insufficiency is detected. A urine analysis showed haematuria and proteinuria and a renal puncture-biopsy revealed an image of IgA nephropathy.Several cases of IgA nephropathy have been reported in the literature associated with ankylosing spondylitis. Some of them occur in patients treated with antitumour necrosis factor, but it is unclear whether this pathology is caused by the treatment or whether treatment failed to prevent its occurrence.Our clinical case highlights the importance of regular monitoring of renal function in patients with ankylosing spondylitis, as well as urinary spotting.The question of whether the disease itself, the treatment or other factors such as immune dysregulation could be held responsible for kidney disease will be addressed in the discussion.

scholarly journals IgA nephropathy associated with ankylosing spondylitis: occurrence in women as well as in men.

1989 ◽  
Vol 48 (5) ◽  
pp. 435-437 ◽  
Author(s):  
K N Lai ◽  
P K Li ◽  
B Hawkins ◽  
F M Lai
Keyword(s):  
Ankylosing Spondylitis ◽  
Iga Nephropathy

P0136COMPARISON OF SECONDARY IGA NEPHROPATHY OF ANKYLOSING SPONDYLITIS AND PRIMARY IGA NEPHROPATHY IN CLINICAL AND PATHOLOGICAL FEATURES

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Qin Xue ◽  
Guang Li Zhang ◽  
Zebo Tian
Keyword(s):  
Retrospective Study ◽  
Ankylosing Spondylitis ◽  
Iga Nephropathy ◽  
Interstitial Fibrosis ◽  
Renal Involvement ◽  
Control Group ◽  
Pathological Features ◽  
Tubular Atrophy ◽  
The Difference ◽  
Clinical And Pathological Features

Abstract Background and Aims Renal involvement is one of the most common extra-articular complications caused by ankylosing spondylitis (AS). The main pathological manifestation is secondary IgA nephropathy(SIgAN) in Chinese AS patients. The difference between SIgAN and primary IgAN (PIgAN) remains unclear due to the lack of cases. Therefore, the aim of this retrospective study was to compare the clinical and pathological features of SIgAN of AS (SIgAN-AS) and PIgAN, to detect the pathogenesis of SIgAN Method Clinical characteristics and pathological data were collected in patients who were diagnosed with IgAN by renal biopsy in our hospital from Jan 2008 to Oct 2018. Patients with SIgAN-AS were recruited by the ratio 1:5 of patients with primary IgAN as the control group in the study. Fifteen patients with SIgAN-AS and Seventy-five patients with PIgAN were enrolled in this retrospective study. Results There were 15 cases in AS group, including 13 male and 2 female. The cohort of 75 patients with PIgAN included 34 male and 41 female. There were more males in AS group 13/15 (86.7%) vs 37/75(49.3%) ,P < 0.05. Compared with PIgAN patients, SIgAN-AS patients had higher incidences of hematuria( 13/15(86.7%)vs 44/75 (58.7%) , P < 0.05), lower levels of 24-hour urinary protein(0.85±0.68 vs 1.57±1.54g, P < 0.05), but higher levels of eGFR (CKD-MDRD formula) (117.60±37.33 vs 85.35±31.36, P < 0.05),eGFR (CKD-EPI formula) (128.01±41.58 vs 92.75±36.09, P < 0.05), Albumin (44.67±3.48 vs 41.09±7.07 g/L, P < 0.05) ESR (43.20 ±33.94 vs 18.79±16.26mm/h, P < 0.001) , and CRP (21.19±30.61 vs 2.11±4.58mg/L, P < 0.001) . From the perspective of renal pathology of PIgAN, SIgA-AS patients had fewer incidences of renal tubular atrophy / interstitial fibrosis of nephropathy (P <0.05). The immunohistostaining analysis showed higher incidences of dominant deposits of single IgA in mesangial cell area (P < 0.05). Conclusion Patients with SIgAN-AS is more common in male and display a milder progression than those with primary IgAN. Majority of the SIgAN-AS can be improved with early intervention.

Comparison of secondary IgA nephropathy in patients with ankylosing spondylitis and rheumatoid arthritis

2019 ◽  
Vol 30 (4) ◽  
pp. 648-656 ◽  
Author(s):  
Dafeng He ◽  
Rong Wang ◽  
Shaoshan Liang ◽  
Dandan Liang ◽  
Feng Xu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Iga Nephropathy

scholarly journals IgA nephropathy in a patient with ankylosing spondylitis well controlled with etanercept

2018 ◽  
Vol 33 (1) ◽  
pp. 85
Author(s):  
Do-Hyeong Lee ◽  
Geun-Tae Kim ◽  
Na-Kyoung Hwang ◽  
Eun-Heui Kim
Keyword(s):  
Ankylosing Spondylitis ◽  
Iga Nephropathy

scholarly journals IgA nephropathy associated acute kidney injury with ankylosing spondylitis and HLA-B27 positive: a case report

2019 ◽  
Vol 8 (1) ◽  
pp. 39-43
Author(s):  
Mahmud Javed Hasan ◽  
ASM Ruhul Quddus ◽  
Nitai Chandra Ray
Keyword(s):  
Acute Kidney Injury ◽  
Ankylosing Spondylitis ◽  
Iga Nephropathy ◽  
Rare Case ◽  
Morning Stiffness ◽  
Kidney Injury ◽  
Creatinine Ratio ◽  
Hla B27 ◽  
Sacroiliac Joints ◽  
X Ray

We are reporting a rare case with ankylosing spondylitis (AS), renal impairment with IgA nephropathy. Here, we discuss the course of diagnosis. A 32 year-old man with bilateral pain of the sacroiliac joints for 5 years and leg swelling for 10 days.  A Diagnosis of AS by HLA-B27 and pelvic X-ray tests, pathological diagnosis and IgA nephropathy based on renal biopsy. We administered methylprednisolone 500 mg/d for 3 consecutive days, followed by methylprednisolone 40 mg oral QD for a month. The patient was followed up once a month. In the sixth month, the patient's serum creatinine had decreased to 0.96 mg/dL, urine microalbumin creatinine ratio decreased to 173.3 mg/g, and albumin had risen to 33.1 g/L. Pain and morning stiffness were relieved. Although the causal relationship between AS and IgA nephropathy in this patient still needs to be established. In clinical practice, patients with AS need to be screened for renal complications. CBMJ 2019 January: vol. 08 no. 01 P: 39-43

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