Human lymphocyte response to selected infectious agents in Reiter's syndrome and ankylosing spondylitis

1982 ◽  
Vol 1 (4) ◽  
pp. 171-175 ◽  
Author(s):  
R. W. Enlow ◽  
W. B. Bias ◽  
R. Bluestone ◽  
F. C. Arnett
Keyword(s):  
Ankylosing Spondylitis ◽  
Human Lymphocyte ◽  
Infectious Agents ◽  
Reiter's Syndrome ◽  
Lymphocyte Response ◽  
Reiter’S Syndrome

Arthritis and Foodborne Bacteria

1994 ◽  
Vol 57 (10) ◽  
pp. 935-941 ◽  
Author(s):  
JAMES L. SMITH
Keyword(s):  
T Cells ◽  
Ankylosing Spondylitis ◽  
Reactive Arthritis ◽  
Molecular Mimicry ◽  
Food Poisoning ◽  
Cell Subset ◽  
Bacterial Cells ◽  
Hla B27 ◽  
Reiter's Syndrome ◽  
Reiter’S Syndrome

Diarrheic episodes caused by the foodborne pathogens Campylobacter, Salmonella, Shigella or Yersinia may lead to a sterile arthritis such as reactive arthritis, Reiter's syndrome or ankylosing spondylitis. Reiter's syndrome and reactive arthritis have been shown to be sequelae in a few well-studied bacterial food poisoning outbreaks. Reactive arthritis, Reiter's syndrome and ankylosing spondylitis show strong familial association related to the gene for HLA-B27 (HLA = human leucocyte antigen) antigen. Why HLA-B27-positive individuals are more susceptible to arthritis is not known, but molecular mimicry between the HLA-B27 antigen and antigens of triggering bacteria has been demonstrated and this mimicry has been proposed as a mechanism involved in etiology of the arthritides. Antigens from bacteria that triggered the arthritis are present in arthritic joints but bacterial cells are not found. Antibodies and T-cells specific for the triggering bacteria have been demonstrated in arthritic patients. T-cells present in synovial joints respond specifically to the particular arthritic triggering pathogen. The cells that respond to bacterial antigens belong to the T-cell subset TH1 that secrete a limited number of cytokines but it is not known if cytokines are involved in arthritis. A few studies have demonstrated that T-cells from the joints of arthritic patients respond to both bacterial and human heat shock proteins indicating that autoimmunity may be involved in causation of arthritis. While only about 2% of a population exposed to a triggering infection will acquire arthritis, these individuals undergo pain and suffering as well as economic hardships as a result of their disease.

Presence of circulating immune complexes in Reiter's syndrome and ankylosing spondylitis

1981 ◽  
Vol 18 (2) ◽  
pp. 291-297 ◽  
Author(s):  
J.T. Rosenbaum ◽  
A.N. Theofilopoulos ◽  
H.O. McDevitt ◽  
A.B. Pereira ◽  
D. Carson ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Reiter's Syndrome ◽  
Reiter’S Syndrome

scholarly journals Influence of trauma on initiation of Reiter's syndrome and ankylosing spondylitis.

1985 ◽  
Vol 44 (12) ◽  
pp. 860-861 ◽  
Author(s):  
G Masson ◽  
P Thomas ◽  
D Bontoux ◽  
M Alcalay
Keyword(s):  
Ankylosing Spondylitis ◽  
Reiter's Syndrome ◽  
Reiter’S Syndrome
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