Halogenated hydrocarbon solvents: Long term effects and biological sampling in human beings

1974 ◽  
Vol 33 (3) ◽  
pp. 251-255 ◽  
Author(s):  
G. Lehnert ◽  
A. Morgan ◽  
D. Szadkowski ◽  
R. L. Zielhuis
Keyword(s):  
Human Beings ◽  
Long Term Effects ◽  
Halogenated Hydrocarbon ◽  
Hydrocarbon Solvents ◽  
Biological Sampling

scholarly journals In vivo Activity of Dust Inhalation at Ratcon Quarry, Sokuro Village, Oluyole, Ibadan Oyo State

2021 ◽  
pp. 9-15
Author(s):  
Adeniyi Abayomi Olusegun
Keyword(s):  
Interstitial Pneumonia ◽  
Exposure Time ◽  
Male Rats ◽  
Human Beings ◽  
Long Term Effects ◽  
Air Concentration ◽  
Dust Inhalation ◽  
Average Body

A total of twenty (20) experimental adult male rats, aged 60 days (7 to 8 weeks) with average body weight between 150-200 gm were grouped, restrained inside laboratory approved plastic holders and exposed to dust inhalation at the quarry site with exposure time of 7, 14 and 21 days to reflect short-term effects while 42days represent long-term effects of dust inhalation on human beings. Each specimen was collected and sacrificed at their grouped survival periods and subjected to laboratory analysis that include Hematology and Histopathology of the lungs. The Hematologyresults of the 7 and 14days specimens revealed no remarkable changes in the Erythrogram (PCV, HB and RBC), the Leucogram (WBC) and the Platelets but however, the results of the 21 and 42 days specimen revealed leukocytosis (increase in WBC), lymphocytosis (increase Lym) and neutrophilia (increase neutrophils) (p<0.05). The Histopathology results of the first specimen (7 days exposure) showed no observable lesion, the second specimen(14 days) showed capillary congestion and mild interstitial pneumonia, while the third (21 days) and fourth (42 days) samples showed the rats graduating from mild to moderate interstitial pneumonia and oedema. The risk of these diseases depends on the amount of organic or inorganic dusts inhaled and deposited in the alveolar region, the air concentration of respirable dust as well as the exposure time and breathing pattern.

scholarly journals ENVIRONMENTAL DEGRADATION AND ITS EFFECTS IN MORADABAD DISTRICT

2020 ◽  
Vol 8 (10) ◽  
pp. 176-181
Author(s):  
S.K. Sharma ◽  
Brahm Singh
Keyword(s):  
Environmental Degradation ◽  
Personal Development ◽  
Noise Pollution ◽  
Human Beings ◽  
Rapid Rise ◽  
Long Term Effects ◽  
Left Behind ◽  
Water Problem ◽  
Day By Day

English: The research study area presented in Moradabad district is a study of environmental degradation and its effect that every person continuously tries to improve his future. Perhaps it is right at the level of personal development, but the current activities of human beings at the level of the environment, only point towards its sensitivity. The current growing problems of the environment around us such as the loss of the actual properties of the soil, unwanted changes in the air composition, rapid rise in the level of water pollutants, rapid loss of biodiversity, rapid rise of noise pollution, incurable and health diseases. Adi is like future crisis on human existence along with environment. At the core of these problems, some natural morals and values ​​are being left behind day by day. The basic forms of nature resources such as water resources, air resources, soil resources, vegetation resources, fauna etc. are changing due to which the nature of problems like soil continuity, global warming and increase in climate and nature disasters, drinking water problem etc. Has taken the researcher has shown the effects of urbanization of Moradabad district in its study area on the environment and the present problems of environmental degradation and its effects. The effects of the study have been evaluated on the short-term and long-term effects of the effects on various components of the environment.   Hindi: प्रस्तुत शोध अध्ययन क्षेत्र मुरादाबाद जनपद में पर्यावरण निम्नीकरण और उसके प्र्रभाव का अध्ययन है कि प्रत्येक मनुष्य अपने भविष्य को बेहतर बनाने का निरंतर प्रयास करता है। शायद व्यक्तिगत विकास के स्तर पर तो यह सही है, परन्तु पर्यावरण केस्तर पर मनुष्य की वर्तमान गतिविधियाँ, उसकी संवेदनशीलता की ओर ही इशारा करती है। हमारे आस-पास के वातावरण की वर्तमान बढ़ती समस्याऐं जैसे मृदा के वास्तविक गुणों का ह्नास, वायु असंगठन में अवांछित परिवर्तन, जल प्रदूषकों के स्तर का तेजी से वृद्धि, जैवविविधता का तेजी से ह्नास ,ध्वनि प्रदूषण, असाध्य व स्वास्थ्य रोगों का तेजी से वृद्धि आदि पर्यावरण के साथ-साथ मानव अस्तित्व पर भविष्य संकट की तरह है। इन समस्याओं के मूल में कुछ प्राकृतिक नैतिकता एवु मूल्यों  को दिन-प्रतिदिन पीछे छोड़ते जा रहे हैं। प्रकृति संसाधनों में जैसे जल संसाधन, वायु संसाधन, मृदा संसाधन, वनस्पति संसाधन, जीव-जन्तुओं आदि के मूल स्वरूप बदलते जा रहे हैं जिससे मृदा अनुर्वतता, वैश्विक तायन एवं जलवायु एवं प्रकृति आपदाओं में वृद्धि, पेय जल की समस्या आदि जैसी समस्याओं का रूप धारण कर लिया है। शोधार्थी ने अपने अध्ययन क्षेत्र जनपद मुरादाबाद के नगरीकरण का वातावरण पर पड़ने वाले प्रभावों को पर्यावरण के निम्नीकरण एवं उसके प्रभाव के वर्तमान में विकराल समस्याओं में दिखाई पड़ रहा है। पर्यावरण के विभिन्न घटकों पर पड़ने वाले प्रभावों को अल्पकालीन एवं दीर्घकालीन परिणाम को अध्ययन के प्रभावों का मूल्यांकन किया गया है।

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Long-Term Effects of Head Lice Tx Unknown

2012 ◽  
Vol 43 (3) ◽  
pp. 42
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Head Lice ◽  
Long Term Effects

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

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