Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus

1985 ◽  
Vol 328 (3) ◽  
pp. 304-309 ◽  
Author(s):  
H. Kilbinger ◽  
M. Nafziger
Keyword(s):  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Muscarine Receptors

Somatostatin modulation of peptide-induced acetylcholine release in guinea pig ileum

1984 ◽  
Vol 246 (5) ◽  
pp. G509-G514 ◽  
Author(s):  
D. H. Teitelbaum ◽  
T. M. O'Dorisio ◽  
W. E. Perkins ◽  
T. S. Gaginella
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Longitudinal Muscle ◽  
Guinea Pig Ileum ◽  
Gut Motility ◽  
Release Of Acetylcholine

The peptides caerulein, neurotensin, somatostatin, and substance P modulate the activity of intestinal neurons and alter gut motility. We examined the effects of these peptides on acetylcholine release from the myenteric plexus and intestinal contractility in vitro. Caerulein (1 X 10(-9) M), neurotensin (1.5 X 10(-6) M), and substance P (1 X 10(-7) M) significantly enhanced the release of [3H]acetylcholine from the myenteric plexus of the guinea pig ileum. This effect was inhibited by tetrodotoxin (1.6 X 10(-6) M). Somatostatin (10(-6) M) inhibited caerulein- and neurotensin-evoked release of acetylcholine but did not inhibit release induced by substance P. Caerulein, neurotensin, and substance P caused contraction of the guinea pig ileal longitudinal muscle. Somatostatin inhibited the contractions induced by caerulein and neurotensin. In contrast, substance P-induced contraction was not inhibited significantly by somatostatin. Thus, in the guinea pig ileum, caerulein-, neurotensin-, and substance P-induced contractility is due, at least in part, to acetylcholine release from the myenteric plexus. The ability of somatostatin to inhibit peptide-induced contractility is selective, and its mechanism may be attributed to inhibition of acetylcholine release.

Modulation of acetylcholine release from the myenteric plexus of guinea-pig ileum by 5-lipoxygenase metabolites of arachidonic acid

1993 ◽  
Vol 239 (1-3) ◽  
pp. 261-264 ◽  
Author(s):  
Shiyu Yoshikawa ◽  
Yuko Fukunaga ◽  
Tadayoshi Takeuchi ◽  
Hideaki Nishio ◽  
Fumiaki Hata
Keyword(s):  
Arachidonic Acid ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Guinea Pig Ileum

scholarly journals Muscarinic Autoinhibition and Modulatory Role of Protein Kinase C in Acetylcholine Release from the Myenteric Plexus of Guinea Pig Ileum.

1997 ◽  
Vol 74 (2) ◽  
pp. 155-163 ◽  
Author(s):  
Noriko Saitoh ◽  
Ritsuko Fujimoto ◽  
Toshiaki Ishii ◽  
Hideaki Nishio ◽  
Tadayoshi Takeuchi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Guinea Pig Ileum ◽  
Kinase C
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