Effect of macrophages on elimination of dermal melanin from the dermis

1984 ◽  
Vol 276 (2) ◽  
pp. 96-98 ◽  
Author(s):  
H. Takematsu ◽  
M. Seiji
Keyword(s):  
Dermal Melanin

Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin

2006 ◽  
Vol 155 (1) ◽  
pp. 119-128 ◽  
Author(s):  
N. Ünver ◽  
P. Freyschmidt-Paul ◽  
S. Hörster ◽  
H. Wenck ◽  
F. Stäb ◽  
...  
Keyword(s):  
Factor Xiiia ◽  
Ageing Skin ◽  
Dermal Melanin

Spectroscopic assessment of dermal melanin using blue vitiligo as an in vivo model

2006 ◽  
Vol 22 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Iltefat Hamzavi ◽  
Natalie Shiff ◽  
Magda Martinka ◽  
Zhiwei Huang ◽  
David McLean ◽  
...  
Keyword(s):  
In Vivo Model ◽  
Dermal Melanin

scholarly journals Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

2014 ◽  
Vol 1 (3) ◽  
pp. 242 ◽  
Author(s):  
Ming TIAN ◽  
Rui HAO ◽  
Suyun FANG ◽  
Yanqiang WANG ◽  
Xiaorong GU ◽  
...  
Keyword(s):  
Genomic Regions ◽  
Dermal Melanin

Positive Relationship between Abdominal Coloration and Dermal Melanin Density in Phrynosomatid Lizards

Copeia ◽  
2003 ◽  
Vol 2003 (4) ◽  
pp. 858-864 ◽  
Author(s):  
Vanessa S. Quinn ◽  
Diana K. Hews
Keyword(s):  
Positive Relationship ◽  
Dermal Melanin

scholarly journals The Inhibition of Dermal Melanin in the Shanks of the Domestic Fowl

1969 ◽  
Vol 48 (6) ◽  
pp. 2137-2142 ◽  
Author(s):  
T.K. Mukherjee ◽  
F.N. Jerome ◽  
B.S. Reinhart
Keyword(s):  
Domestic Fowl ◽  
Dermal Melanin

Dermal melanin concentration of yellow perch Perca flavescens in relation to water transparency

2015 ◽  
Vol 87 (5) ◽  
pp. 1248-1253 ◽  
Author(s):  
G. Rheault ◽  
M. Langevin ◽  
G. Cabana ◽  
H. Glémet
Keyword(s):  
Yellow Perch ◽  
Perca Flavescens ◽  
Water Transparency ◽  
Dermal Melanin

scholarly journals Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 454
Author(s):  
Hyoung Moon Kim ◽  
Seyeon Oh ◽  
Kyung-A Byun ◽  
Jin Young Yang ◽  
Hye Jin Sun ◽  
...  
Keyword(s):  
Animal Model ◽  
Lymph Nodes ◽  
Skin Pigmentation ◽  
Lymphatic Vessels ◽  
Tyrosinase Activity ◽  
Erk Pathway ◽  
Melanin Content ◽  
Exposed Animal ◽  
Dermal Melanin ◽  
Endothelial Marker

Dermal macrophages containing melanin increase skin pigmentation since dermal melanin removal is slower than epidermal melanin removal. Lymphatic vessels are also involved in melanin clearance. We evaluated whether radiofrequency (RF) irradiation induced an increase in HSP90, which promotes lymphangiogenesis by activating the BRAF/MEK/ERK pathway and decreasing tyrosinase activity, in the UV-B exposed animal model. The HSP90/BRAF/MEK/ERK pathway was upregulated by RF. Tyrosinase activity and the VEGF-C/VEGFR 3/PI3K/pAKT1/2/pERK1/2 pathway, which increase lymphangiogenesis, as well as the expression of the lymphatic endothelial marker LYVE-1, were increased by RF. Additionally, the number of melanin-containing dermal macrophages, the melanin content in the lymph nodes, and melanin deposition in the skin were decreased by RF. In conclusion, RF increased HSP90/BRAF/MEK/ERK expression, which decreased tyrosinase activity and increased lymphangiogenesis to eventually promote the clearance of dermal melanin-containing macrophages, thereby decreasing skin pigmentation.

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