On the mode of action of clonidine: Relationship between effects on behaviour and cyclic nucleotide content in mouse brain

1977 ◽  
Vol 298 (1) ◽  
pp. 7-14 ◽  
Author(s):  
S. W. Gumulka ◽  
V. Dinnendahl ◽  
D. Bartmus ◽  
P. S. Sch�nh�fer ◽  
K. Stock
Keyword(s):  
Mouse Brain ◽  
Cyclic Nucleotide ◽  
Mode Of Action ◽  
Nucleotide Content

Changes in the cyclic nucleotide content in wound tissues during healing

1979 ◽  
Vol 87 (6) ◽  
pp. 625-627 ◽  
Author(s):  
I. M. Nosova ◽  
M. A. Zaidenberg ◽  
V. N. Petrosova ◽  
R. D. Seifulla ◽  
A. A. Karelin
Keyword(s):  
Cyclic Nucleotide ◽  
Nucleotide Content

The mode of action of homocysteine on mouse brain glutamic decarboxylase and γ-aminobutyrate aminotransferase

1977 ◽  
Vol 55 (9) ◽  
pp. 1013-1018 ◽  
Author(s):  
G. Tunnicliff ◽  
T. T. Ngo
Keyword(s):  
Amino Acid ◽  
Mouse Brain ◽  
Mode Of Action ◽  
Acid Metabolism ◽  
Competitive Inhibition ◽  
The Other ◽  
Aminobutyric Acid ◽  
Aminobutyrate Aminotransferase ◽  
Dual Action

In the belief that homocysteine-induced convulsions might be related to alterations in brain γ-aminobutyric acid metabolism, we have studied the action of this amino acid on the activity of glutamic decarboxylase (GAD, EC 4.1.1.15) and γ-aminobutyrate aminotransferase (EC 2.6.1.19)of mouse brain in vitro. DL-homocysteine competitively inhibited GAD with respect to both L-glutamate and pyridoxal 5′-phosphate. The respective Ki's were 3.8 mM and 0.3 mM, The activity of GABA-T also was altered in the presence of DL-homocysteine. A competitive inhibition (Ki = 6 mM) was observed with γ-aminobutyric acid, and an uncompetitive inhibition with respect to pyridoxal 5′-phosphate and α-ketoglutarate. These results are explained in terms of a dual action of homocysteine on each of the enzymes: one involving a competition for substrate binding site and the other involving the formation of an inactive inhibitor – cofactor complex. The significance of the inhibition of these enzymes of γ-aminobutyric acid metabolism is discussed in relation to the convulsant action of homocysteine.

Influence of Anoxia and Dinitrophenol on the Phosphorylase a Activity and the Cyclic Nucleotide Content of Smooth Muscle

2009 ◽  
Vol 52 (5) ◽  
pp. 328-334 ◽  
Author(s):  
H. Arnqvist ◽  
H. Groth ◽  
L. Lundholm ◽  
G. Pettersson ◽  
G. Wingren
Keyword(s):  
Smooth Muscle ◽  
Cyclic Nucleotide ◽  
Nucleotide Content

Epinephrine-induced changes in the cyclic nucleotide content of fish melanoma cells

1982 ◽  
Vol 47 (1) ◽  
pp. 88-93 ◽  
Author(s):  
S. Negishi ◽  
M. Masada ◽  
Y. Wakamatsu ◽  
T. Ohoka ◽  
M. Obika
Keyword(s):  
Cyclic Nucleotide ◽  
Melanoma Cells ◽  
Nucleotide Content ◽  
Induced Changes
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