Decreased glycolytic flux rate in the isolated perfused rat brain after pretreatment with 6-aminonicotinamide

1975 ◽  
Vol 290 (2-3) ◽  
pp. 323-327 ◽  
Author(s):  
J. Krieglstein ◽  
R. Stock
Keyword(s):  
Rat Brain ◽  
Glycolytic Flux ◽  
Flux Rate ◽  
Isolated Perfused Rat Brain

Eicosanoids in Rat Brain during Ischemia and Reperfusion—Correlation to DC Depolarization

1990 ◽  
Vol 10 (3) ◽  
pp. 358-364 ◽  
Author(s):  
F. Tegtmeier ◽  
C. Weber ◽  
U. Heister ◽  
I. Haker ◽  
D. Scheller ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Rat Brain ◽  
Direct Current ◽  
Eicosatetraenoic Acid ◽  
Ischemia And Reperfusion ◽  
Ischemic Time ◽  
Isolated Perfused Rat Brain ◽  
Current Potential

The effects of complete ischemia on cerebral arachidonic acid (AA) metabolism were investigated in the isolated perfused rat brain. During 12.5 min of ischemia, AA, 5-hydroxy-6,8,11,14-eicosatetraenoic acid, and 15-hydroxy-5,8,11,13-eicosatetraenoic acid increased 129-, 4-, and 10-fold, respectively, while subsequent reperfusion for 30 min resulted in normalized levels independently of the duration of preceding ischemia. Prostaglandin (PG) F2α, PGE2, PGD2, 6-keto-PGF1α, and thromboxane (Tx) B2 remained at preischemic levels during 12.5 min of complete ischemia. However, at the end of subsequent reperfusion for 30 min, the levels of the prostanoids PGF2α, PGE2, PGD2, 6-keto-PGF1α, and TxB2 increased according to the preceding ischemic time. The levels reached a maximum after 7.5 min of ischemia and were elevated by 7-, 14-, 48-, 3-, and 30-fold, respectively. A prolongation of ischemia of up to 12.5 min was not associated with further increases of prostanoids at the end of reperfusion. The mechanisms underlying the metabolism of eicosanoids are discussed in relation to the changes of cortical direct current potential.

Monoamine Metabolism in the Isolated Perfused Rat Brain

1976 ◽  
Vol 4 (1) ◽  
pp. 22-26 ◽  
Author(s):  
H. F. WOODS ◽  
A. R. GREEN ◽  
M. B. H. YOUDIM ◽  
D. G. GRAHAME-SMITH
Keyword(s):  
Rat Brain ◽  
Monoamine Metabolism ◽  
Isolated Perfused Rat Brain

Effects of dimethylsulfoxide on metabolism of isolated perfused rat brain

1976 ◽  
Vol 25 (9) ◽  
pp. 1115-1117 ◽  
Author(s):  
Amal K. Ghosh ◽  
Tatsuji Ito ◽  
Sabita Ghosh ◽  
Henry A. Sloviter
Keyword(s):  
Rat Brain ◽  
Isolated Perfused Rat Brain
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