Adenylate cyclase of the dog gastric mucosa: Stimulation by histamine and inhibition by metiamide

1976 ◽  
Vol 294 (2) ◽  
pp. 207-208 ◽  
Author(s):  
H.-J. Ruoff ◽  
K.-FR. Sewing
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase ◽  
Stimulation By Histamine

Adenylate cyclase in human gastric mucosa: its activation by histamine in morphologically different biopsy specimens

1979 ◽  
Vol 57 (14) ◽  
pp. 725-730 ◽  
Author(s):  
H. -J. Ruoff ◽  
B. Painz ◽  
M. Becker ◽  
M. Rack ◽  
K. -Fr Sewing ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase ◽  
Human Gastric Mucosa ◽  
Biopsy Specimens

Adenylate Cyclase of Human Gastric Mucosa

Digestion ◽  
1977 ◽  
Vol 16 (1-2) ◽  
pp. 175-179 ◽  
Author(s):  
Bernd Simon ◽  
Horst Kather
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase ◽  
Human Gastric Mucosa

Adrenaline Sensitive Adenylate Cyclase in Human Gastric Mucosa

Pharmacology ◽  
1981 ◽  
Vol 23 (3) ◽  
pp. 137-144 ◽  
Author(s):  
H.-J. Ruoff ◽  
Brigitte Painz ◽  
Ulrich Gladziwa ◽  
Michael Becker ◽  
K.-F. Sewing ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase ◽  
Human Gastric Mucosa

Effect of histamine on canine gastric mucosal adenylate cyclase.

1977 ◽  
Vol 232 (1) ◽  
pp. E35
Author(s):  
R R Dozois ◽  
A Wollin ◽  
R D Rettmann ◽  
T P Dousa
Keyword(s):  
Gastric Mucosa ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Antral Mucosa ◽  
Fundic Mucosa ◽  
H2 Receptors ◽  
Dose Dependent ◽  
Stimulation Of

The effects of histamine, Nalpha-dimethylhistamine, 4,5-methylhistamine, Ntau-methylhistamine, pentagastrin, carbachol, and NaF on the adenylate cyclase activity from canine gastric mucosa were investigated in cell-free preparations. In gastric fundic mucosa, histamine (10(-4) M), Nalpha-dimethylhistamine (10(-4) M), 4,5-methylhistamine (10(-4 M), and NaF (10)-2) M) significantly (P less than 0.001) increased adenylate cyclase activity (means+/-SE) by 44.7+/-6.6, 49.4+/-6.7, 34.0+/-6.4, and 572.0+/-100%, respectively, above basal activity. The effect of histamine and Na-dimethyl histamine was dose-dependent. In contrast, other tested agents failed to stimulate the formation of cyclic AMP in gastric fundic mucosa. Metiamide (10(-4) M) blocked the stimulation of fundic mucosa adenylate cyclase by histamine and Nalpha-dimethylhistamine, without significantly altering basal and NaF-induced adenylate cyclase activity. Histamine, however, did not stimulate the adenylate cyclase activity from the gastric antral mucosa. The findings support the proposal that the canine gastric acid response to histamine may be mediated by cyclic AMP formed in response to stimulation of histamine H2-receptors.

A model eliciting transient responses

1984 ◽  
Vol 246 (1) ◽  
pp. R114-R121 ◽  
Author(s):  
E. B. Ekblad ◽  
V. Licko
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase ◽  
Chemical Transformation ◽  
Transient Response ◽  
Short Circuit ◽  
Short Circuit Current ◽  
Transient Responses ◽  
Histamine Secretion ◽  
Cyclic Monophosphate ◽  
Camp Stimulation

A simple parametrically controlled chemical transformation scheme is used to exemplify a model with transient response to sustained stimulation. More complicated schemes are also discussed. Analyses of three experimental examples are given: short-circuit current changes in toad bladder exposed to adenosine 3',5'-cyclic monophosphate (cAMP) stimulation; histamine secretion in acetylcholine-stimulated frog gastric mucosa; and cAMP dynamics, expressed in terms of adenylate cyclase dynamics, in histamine-stimulated frog gastric mucosa. The model responds primarily to the changes of the stimulator level, although it is not a model with derivative control.

Comparison of Mg2+ and Mn2+ as metal cofactors for histamine-stimulated adenylate cyclase in guinea pig gastric mucosa

1987 ◽  
Vol 36 (11) ◽  
pp. 1847-1848 ◽  
Author(s):  
L.Allen Barker ◽  
Thomas Mittag ◽  
Rocio Calle ◽  
Susan Norris ◽  
Anne Tormay
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase ◽  
Guinea Pig ◽  
Metal Cofactors

Histamine receptors and cyclic AMP

1980 ◽  
Vol 58 (9) ◽  
pp. 1023-1030 ◽  
Author(s):  
John H. McNeill
Keyword(s):  
Adipose Tissue ◽  
Gastric Mucosa ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Histamine Receptors ◽  
Rat Uterus ◽  
Receptor Stimulation ◽  
Amp System ◽  
Organ Systems ◽  
Stimulation Of

The identification and characterization of histamine receptors in the organ systems of various species has been made possible in recent years by the introduction of relatively selective agonists and antagonists of H1 and H2 receptors. H2 receptors have now been clearly demonstrated in gastric mucosa, heart, rat uterus, brain, and adipose tissue. Less well-defined H2 receptor systems have also been described in the vasculature, bronchioles, and other smooth muscles as well as in the thyroid gland and lymphocytes. In tissues where it has been examined a close correlation between H2 receptors and the adenylate cyclase – cyclic AMP system has been found. With the exception of the central nervous system stimulation of H1 receptors does not seem to be involved with cyclic AMP. In the case of the brain the H1 receptor stimulation of adenylate cyclase can be differentiated from H2 receptor stimulation of the enzyme by the use of blocking agents and by the fact that the H1 receptor response is enhanced in the presence of adenosine. Studies of the involvement of histamine with the adenylate cyclase – cyclic AMP system have been concentrated on such tissues as gastric mucosa, heart, rat uterus, brain, and adipose tissue. The present review will concentrate on the literature concerning those tissues.

Histamine-sensitive adenylate cyclase in fundic gastric mucosa

1977 ◽  
Vol 22 (8) ◽  
pp. 746-747 ◽  
Author(s):  
Bernd Simon ◽  
Horst Kather
Keyword(s):  
Gastric Mucosa ◽  
Adenylate Cyclase
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