Changes in Na+ and K+ permeability of red cells induced by the direct lytic factor of cobra venom and phospholipase A

1972 ◽  
Vol 274 (1) ◽  
pp. 81-90 ◽  
Author(s):  
C. Jacobi ◽  
P. -G. Lankisch ◽  
Karin Schoner ◽  
W. Vogt
Keyword(s):  
Red Cells ◽  
Phospholipase A ◽  
Cobra Venom ◽  
Direct Lytic Factor ◽  
K Permeability

scholarly journals Inhibitors of complement derived from the erythrocyte membrane in paroxysmal nocturnal hemoglobinuria

Blood ◽  
1980 ◽  
Vol 55 (5) ◽  
pp. 772-776 ◽  
Author(s):  
C Chua ◽  
EM Hoffmann ◽  
JP Adams ◽  
WF Rosse
Keyword(s):  
Erythrocyte Membrane ◽  
Complement Activation ◽  
Inhibitory Activity ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Cell Lysis ◽  
Red Cells ◽  
Cobra Venom ◽  
Normal Cells ◽  
Complement Lysis

Abstract Extracts of the membranes of normal red cells and red cells from all subpopulations of paroxysmal nocturnal (PNH) red cells inhibited antibody-mediated complement activation. These extracts were shown to accelerate decay of the complement complex. C42, and the relative amount of inhibitory activity was similar in normal and PNH membranes. Inhibitors derived from normal red cells markedly decreased lysis of both PNH and normal cells when antibody was present in excess and complement was limiting. These same inhibitors decreased PNH cell lysis to a much lesser degree when complement was activated with cobra venom or acidified serum. The susceptibility of the PNH cell to complement lysis because of an increased fixation of C3 to its membrane is not due to a difference in membrane-associated accelerator of the decay of the C42 complex.

Action of phospholipase a on aggregation of red cells and platelets

1976 ◽  
Vol 82 (6) ◽  
pp. 1761-1763
Author(s):  
G. Ya. Levin ◽  
Yu. A. Sheremet'ev
Keyword(s):  
Red Cells ◽  
Phospholipase A
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