Immobilization of Streptomyces phaeochromogenes cells at a high concentration by radiation-induced polymerization of glass-forming monomers

1978 ◽  
Vol 6 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Minoru Kumakura ◽  
Masaru Yoshida ◽  
Isao Kaetsu
Keyword(s):  
High Concentration ◽  
Glass Forming ◽  
Radiation Induced

MEDICAL APPLICATIONS OF PARTICLE-INDUCED X-RAY EMISSION

2008 ◽  
Vol 18 (03n04) ◽  
pp. 101-110
Author(s):  
S. HARADA ◽  
S. EHARA ◽  
K. ISHII ◽  
H. YAMAZAKI ◽  
S. MATSUYAMA ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Liquid Core ◽  
Medical Applications ◽  
High Concentration ◽  
Antitumor Effects ◽  
X Ray ◽  
Core Content ◽  
Dependent Endonuclease ◽  
Radiation Induced ◽  
Induced Apoptosis

We report two medical applications of particle-induced X-ray emission (PIXE) as described below (1) Observation of biological events: The kinetics of trace elements during the initiation of radiation-induced apoptosis (RIA) was observed using a micro-PIXE and PIXE. RIA is a process in which irradiated cells commit suicide; it results in the removal of severely damaged and harmful cells. During RIA, cytochrome c is released from the mitochondria and reaches the nucleus, where it activates a Ca- or Mg-dependent endonuclease. We examined this phenomenon by using a micro-PIXE and PIXE. A high concentration of Fe was detected in the stroma of cells in the early apoptotic phase. We also observed accumulation of large amounts of Ca and Mg in the nucleus.(2) Development of liquid-core microcapsules for novel cancer chemoradiotherapy: Currently, we are developing liquid-core (containing an anticancer drug) microcapsules that release their core content upon irradiation. These microcapsules will localize the anticancer drug within the irradiated field. The outer shell of these microcapsules is prepared from alginate and hyaluronic acid and polymerized by Fe, while the anticancer drug Paraplatin®(carboplatin) containing Pt is the liquid core. The micro-PIXE revealed that these microcapsules released their core content after irradiation, and the amount of carboplatin released was measured by PIXE. More than 83.1% ± 8.3% of the microcapsules were ruptured, and the amount of carboplatin released was more than 81.2% ± 2.3%. Thus, the combination of radiotherapy and chemotherapy showed improved antitumor effects and a decrease in adverse effects because of drug localization.

scholarly journals BONDING OF ALUMINA AND METAL USING BULK METALLIC GLASS FORMING ALLOY

2009 ◽  
Vol 23 (06n07) ◽  
pp. 1306-1312 ◽  
Author(s):  
JINJUN ZHANG ◽  
JIANSHENG GU ◽  
LEI LI ◽  
YONG HUAN ◽  
BINGCHEN WEI
Keyword(s):  
Metallic Glass ◽  
Bulk Metallic Glass ◽  
Electronic Devices ◽  
Direct Application ◽  
Filler Alloy ◽  
High Concentration ◽  
Practical Applications ◽  
Glass Forming ◽  
Technology Industry ◽  
Metal Ceramic

Metal-alumina joints have found various practical applications in electronic devices and high technology industry. However, making of sound metal ceramic brazed couple is still a challenge in terms of its direct application in the industry. In this work we successfully braze copper with Al 2 O 3 ceramic using Zr 52.5 Cu 17.9 Ni 14.6 Al 10 Ti 5 bulk metallic glass forming alloy as filler alloy. The shear strength of the joints can reach 140 MPa, and the microstructrural analysis confirms a reliable chemical boning of the interface. The results show that the bulk metallic glass forming alloys with high concentration of active elements are prospective for using as filler alloy in metal-ceramic bonding.

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