Variation in alpha-L-fucosidase properties among 28 inbred mouse strains: Six strains have high enzyme activity and heat-stabile enzyme with a variant pH-activity curve; twenty-two strains have low activity and heat-labile enzyme

1986 ◽  
Vol 24 (5-6) ◽  
pp. 469-483 ◽  
Author(s):  
William G. Johnson ◽  
Jacqueline L. Hong
Keyword(s):  
Enzyme Activity ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Heat Labile ◽  
High Enzyme ◽  
Activity Curve ◽  
Low Activity ◽  
High Enzyme Activity

Su1843 High Enzyme Activity UGT1A1 or Low Activity Ugt1a8 and Ugt2b4 Genotypes Increase Esophageal Cancer Risk

2012 ◽  
Vol 142 (5) ◽  
pp. S-517
Author(s):  
Polat Dura ◽  
Jody Salomon ◽  
Rene te Morsche ◽  
Hennie Roelofs ◽  
Jon Kristinsson ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Enzyme Activity ◽  
Cancer Risk ◽  
High Enzyme ◽  
Low Activity ◽  
High Enzyme Activity

Distribution of meprin in kidneys from mice with high- and low-meprin activity

1987 ◽  
Vol 253 (4) ◽  
pp. C535-C540 ◽  
Author(s):  
S. S. Craig ◽  
J. F. Reckelhoff ◽  
J. S. Bond
Keyword(s):  
Electron Microscopy ◽  
Brush Border ◽  
Inbred Mouse ◽  
Light And Electron Microscopy ◽  
Mouse Strains ◽  
Immunoperoxidase Technique ◽  
Inbred Mouse Strains ◽  
Western Blots ◽  
Reactive Material ◽  
Low Activity

An inherited deficiency of a metalloendopeptidase (meprin) activity occurs in kidneys of many inbred mouse strains. To clarify whether meprin protein is present in low-activity strains and determine the distribution of meprin in kidneys of mice with high- and low-meprin activities, kidney slices were stained through the use of the indirect immunoperoxidase technique and examined by light and electron microscopy. Light microscopy at high dilutions of anti-meprin IgG confirmed the brush border localization of meprin in high-meprin activity strains and revealed no detectable cross-reactive material in low-meprin activity strains. However, light and electron microscopy studies that use lower dilutions of anti-meprin immunoglobulin G (IgG) revealed cross-reactivity in low-activity strains, also at the luminal surface of the proximal tubules. Studies at lower magnifications indicated that meprin is primarily associated with the juxtamedullary region of the kidney in both high- and low-activity strains. Western blots of urinary proteins showed significant amounts of meprin-like proteins, but only in the urine of mice with high-meprin activity. The low activity of meprin in some inbred mouse strains is not associated with the presence of the protein in compartments of kidney cells other than the brush border or with secretion of the protein into the urine.

scholarly journals THE Ah PHENOTYPE. SURVEY OF FORTY-EIGHT RAT STRAINS AND TWENTY INBRED MOUSE STRAINS

Genetics ◽  
1982 ◽  
Vol 100 (1) ◽  
pp. 79-87
Author(s):  
Daniel W Nebert ◽  
Nancy M Jensen ◽  
Hisashi Shinozuka ◽  
Heinz W Kunz ◽  
Thomas J Gill
Keyword(s):  
Specific Activity ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Mouse Strains ◽  
Ah Receptor ◽  
Inbred Mouse Strains ◽  
Sprague Dawley ◽  
Rat Strains ◽  
Specific Activities ◽  
Inbred Rat

ABSTRACT Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.

scholarly journals Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains

1999 ◽  
Vol 40 (2) ◽  
pp. 295-301 ◽  
Author(s):  
John J. Albers ◽  
Wendy Pitman ◽  
Gertrud Wolfbauer ◽  
Marian C. Cheung ◽  
Hal Kennedy ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Phospholipid Transfer Protein ◽  
Inbred Mouse Strains ◽  
Protein Activity ◽  
Transfer Protein ◽  
Phospholipid Transfer

scholarly journals Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

2012 ◽  
Vol 13 (1) ◽  
pp. 94 ◽  
Author(s):  
Holger Hackstein ◽  
Andreas Wachtendorf ◽  
Sabine Kranz ◽  
Jürgen Lohmeyer ◽  
Gregor Bein ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Dendritic Cell Subsets ◽  
Lymphocyte Populations

Hemoglobin Solubility and agr-Chain Structure in Crosses between Two Inbred Mouse Strains

Science ◽  
1964 ◽  
Vol 143 (3603) ◽  
pp. 252-253 ◽  
Author(s):  
J. J. Hutton ◽  
R. S. Schweet ◽  
H. G. Wolfe ◽  
E. S. Russell
Keyword(s):  
Inbred Mouse ◽  
Chain Structure ◽  
Mouse Strains ◽  
Inbred Mouse Strains
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