Effects of pentoxifylline on red blood cell deformability and blood viscosity under hyperosmolar conditions

1977 ◽  
Vol 299 (2) ◽  
pp. 197-200 ◽  
Author(s):  
H. Leonhardt ◽  
H. -G. Grigoleit
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

A physiometer for simultaneous measurement of whole blood viscosity and its determinants: hematocrit and red blood cell deformability

The Analyst ◽  
2019 ◽  
Vol 144 (9) ◽  
pp. 3144-3157 ◽  
Author(s):  
Byung Jun Kim ◽  
Ye Sung Lee ◽  
Alexander Zhbanov ◽  
Sung Yang
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Simultaneous Measurement ◽  
Whole Blood ◽  
Cell Deformability ◽  
Whole Blood Viscosity ◽  
Red Blood Cell Deformability ◽  
Rbc Deformability

In this study, a microfluidic-based physiometer capable of measuring the whole blood viscosity, hematocrit, and red blood cell (RBC) deformability on a chip is introduced.

scholarly journals Effect of Dietary Supplementation of n-3 Polyunsaturated Fatty Acids (PUFA) on Red Blood Cell Deformability and Blood Viscosity in Rats

2003 ◽  
Vol 52 (8) ◽  
pp. 397-406 ◽  
Author(s):  
Nakamichi WATANABE ◽  
Katsura FUNAYAMA ◽  
Fumiko KIMURA ◽  
Yasushi ENDO ◽  
Kenshiro FUJIMOTO ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Cell ◽  
Polyunsaturated Fatty Acids ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Dietary Supplementation ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals VARIACIÓN DE LA VISCOSIDAD PLASMÁTICA EN CONEJOS INDUCIDOS A UNA DIABETES ALOXÁNICA

2019 ◽  
pp. 27-30
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Alloxan Diabetes ◽  
Diabetic Patients ◽  
Cell Deformability ◽  
Red Blood Cell Deformability ◽  
Palabras Clave ◽  
Diabetic Rabbits

VARIACIÓN DE LA VISCOSIDAD PLASMÁTICA EN CONEJOS INDUCIDOS A UNA DIABETES ALOXÁNICA VARIATION OF PLASMATIC VISCOSITY IN ALLOXAN-INDUCED DIABETIC RABBITS Gonzales Medrano, M. Fernando, Infantas Mesías, Delia y Sam Torres, Rosa DOI: https://doi.org/10.33017/RevECIPeru2009.0006/ RESUMEN Se investigó la variación de la viscosidad plasmática en conejos inducidos a una diabetes aloxánica. Adicionalmente, los valores de hematocrito, densidad plasmática y deformabilidad celular de glóbulos rojos fueron estimados. Los animales diabéticos presentaron pérdida de peso mientras que la densidad y viscosidad plasmática se incrementaron. Los valores de hematocrito no mostraron diferencias estadísticas significativas. Estos resultados sugieren que el incremento del valor de la viscosidad plasmática es un factor involucrado en la viscosidad sanguínea descrita para pacientes diabéticos con descompensación. Palabras clave: Viscosidad plasmática, diabetes aloxánica, conejos. ABSTRACT The variation of plasmatic viscosity in alloxan-induced diabetic rabbits was investigated. Additionally, hematocrit values, plasmatic density and red blood cell deformability were estimated. The diabetic animals showed loss weight whereas the density and viscosity of plasma were increased. The Hematocrit values did not show any significative statistical differences. These results suggest the increased level of plasmatic viscosity is an involucrated factor in the blood viscosity described for decompensated diabetic patients. Keywords: Plasmatic viscosity, alloxan-diabetes, rabbits.

scholarly journals Multiplexed fluidic plunger mechanism for the measurement of red blood cell deformability

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Marie-Eve Myrand-Lapierre ◽  
Xiaoyan Deng ◽  
Richard R. Ang ◽  
Kerryn Matthews ◽  
Aline T. Santoso ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Heterogeneous Sample ◽  
Red Blood Cell Deformability

Mechanism for multiplexed measurement of single red blood cell deformability to evaluate pathological cells in a heterogeneous sample.

Limited effects of activated protein C on red blood cell deformability

2013 ◽  
Vol 53 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Michael Piagnerelli ◽  
Hassane Njimi ◽  
Tatiana Veloso Coelho ◽  
Giulia Reggiori ◽  
Diego Castanares Zapatero ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Protein C ◽  
Activated Protein C ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Susceptibility of density-fractionated erythrocytes to subhaemolytic mechanical shear stress

2018 ◽  
Vol 42 (3) ◽  
pp. 151-157 ◽  
Author(s):  
Antony P McNamee ◽  
Kieran Richardson ◽  
Jarod Horobin ◽  
Lennart Kuck ◽  
Michael J Simmonds
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Shear Stresses ◽  
Mechanical Stimuli ◽  
Cell Deformability ◽  
Red Blood Cell Deformability ◽  
Cell Age ◽  
Low Shear

Introduction: Accumulating evidence demonstrates that subhaemolytic mechanical stresses, typical of circulatory support, induce physical and biochemical changes to red blood cells. It remains unclear, however, whether cell age affects susceptibility to these mechanical forces. This study thus examined the sensitivity of density-fractionated red blood cells to sublethal mechanical stresses. Methods: Red blood cells were isolated and washed twice, with the least and most dense fractions being obtained following centrifugation (1500 g × 5 min). Red blood cell deformability was determined across an osmotic gradient and a range of shear stresses (0.3–50 Pa). Cell deformability was also quantified before and after 300 s exposure to shear stresses known to decrease (64 Pa) or increase (10 Pa) red blood cell deformability. The time course of accumulated sublethal damage that occurred during exposure to 64 Pa was also examined. Results: Dense red blood cells exhibited decreased capacity to deform when compared with less dense cells. Cellular response to mechanical stimuli was similar in trend for all red blood cells, independent of density; however, the magnitude of impairment in cell deformability was exacerbated in dense cells. Moreover, the rate of impairment in cellular deformability, induced by 64 Pa, was more rapid for dense cells. Relative improvement in red blood cell deformability, due to low-shear conditioning (10 Pa), was consistent for both cell populations. Conclusion: Red blood cell populations respond differently to mechanical stimuli: older (more dense) cells are highly susceptible to sublethal mechanical trauma, while cell age (density) does not appear to alter the magnitude of improved cell deformability following low-shear conditioning.

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