An initial characterization of human heart ?-adrenoceptors and their mediation of the positive inotropic effects of catecholamines

1982 ◽  
Vol 319 (3) ◽  
pp. 216-221 ◽  
Author(s):  
Alberto J. Kaumann ◽  
Horst Lemoine ◽  
Tom H. Morris ◽  
Ulrich Schwederski
Keyword(s):  
Human Heart ◽  
Inotropic Effects ◽  
Initial Characterization ◽  
Positive Inotropic Effects

Characterization of the histamine receptors in rabbit left atria

1981 ◽  
Vol 59 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Alicia Polanin ◽  
John H. McNeill
Keyword(s):  
Left Atrial ◽  
Histamine Receptor ◽  
Histamine Receptors ◽  
Receptor Blockade ◽  
Inotropic Response ◽  
Receptor Stimulation ◽  
Inotropic Effects ◽  
Receptor Antagonism ◽  
Positive Inotropic Effects

The effects of selective histamine receptor analogs were studied in electrically paced rabbit left atria. Atrial tension was increased by histamine (an H1 and H2 agonist), 4-methylhistamine and impromidine (H2 agonists), and 2-pyridylethylamine (PEA) (an H1 agonist). The responses to histamine and impromidine were not altered by propranolol (1 × 10−7 M) or reserpine pretreatment. However, the responses to 4-methylhistamine and PEA were significantly decreased upon pretreatment with propranolol or reserpine. Promethazine pretreatment (H1 receptor blockade) antagonized the inotropic effects of histamine and PEA but had no effect on the responses to 4-methylhistamine or impromidine. Cimetidine pretreatment (H2 receptor antagonism) competitively blocked the positive inotropic effects of histamine, 4-methylhistamine, and impromidine. These results suggest that the left atrial inotropic response is mediated through H1 and H2 receptor stimulation.

Spare Receptors for β-Adrenoceptor-Mediated Positive Inotropic Effects of Catecholamines in the Human Heart

1992 ◽  
Vol 19 (2) ◽  
pp. 222-232 ◽  
Author(s):  
Lindsay Brown ◽  
Nicola M. Deighton ◽  
Susanne Bals ◽  
Werner Söhlmann ◽  
Hans-Reinhard Zerkowski ◽  
...  
Keyword(s):  
Human Heart ◽  
Inotropic Effects ◽  
Spare Receptors ◽  
Positive Inotropic Effects

scholarly journals Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing.

RNA Biology ◽  
2021 ◽  
Author(s):  
Peter Zorn ◽  
Danny Misiak ◽  
Michael Gekle ◽  
Marcel Köhn
Keyword(s):  
Initial Characterization
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