Immunohistochemical study of cells positive for glial fibrillary acidic protein (GFAP) in the human pituitary gland, with special reference to folliculo-stellate cells

1989 ◽  
Vol 91 (3) ◽  
pp. 227-234 ◽  
Author(s):  
P. Redecker ◽  
J. Fechner
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Pituitary Gland ◽  
Special Reference ◽  
Immunohistochemical Study ◽  
Stellate Cells ◽  
Acidic Protein ◽  
Human Pituitary ◽  
Human Pituitary Gland

scholarly journals Intermediate Filaments in the Human Pituitary Gland: An Immunohistochemical Study

1990 ◽  
Vol 17 (2) ◽  
pp. 131-136 ◽  
Author(s):  
W.C. Halliday ◽  
S.L. Asa ◽  
K. Kovacs ◽  
B.W. Scheithauer
Keyword(s):  
Pituitary Gland ◽  
Intermediate Filaments ◽  
Immunohistochemical Study ◽  
Serial Sections ◽  
Null Cell ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Immunohistochemical Techniques ◽  
Corticotroph Adenomas ◽  
Small Subpopulation

ABSTRACT:Normal pituitaries, pituitaries showing CHC and selected adenomas were assessed for their possible content of intermediate filaments (IF), using immunohistochemical techniques. Normal pituitaries were stained for each of the five known IF (Cytokeratins (CK), glial fibrillary acidic protein (GFAP), desmin, vimentin, and neurofilaments (NF)). Desmin could not be demonstrated, and NF staining was limited to processes in the posterior gland. In serial sections, CK was demonstrated in some corticotrophs, somatotrophs, and lactotrophs. Vimentin was limited to processes in the posterior gland. Folliculo-stellate cells (FSC), demonstrated by staining for SlOO protein, exhibited a small subpopulation staining for CK, and another subpopulation staining for GFAP. GFAP was also demonstrated in glial processes in the posterior gland. Cells showing Crooke's hyaline change stained intensely for CK. Null cell adenomas did not stain for CK. Corticotroph adenomas, somatotroph adenomas, with or without fibrous bodies, and lactotroph adenomas contain CK-immunoreactive cells. We conclude that CK is the major IF present in the anterior pituitary gland, within some normal corticotrophs, somatotrophs and lactotrophs, and also in adenomas derived from these cells.

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

Isolation of five active thyrotropin components from human pituitary gland

1975 ◽  
Vol 379 (1) ◽  
pp. 247-261 ◽  
Author(s):  
Paul Roos ◽  
D.V. Dervartanian ◽  
Gunilla Jacobson ◽  
Leif Wide
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland
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