Mitochondrial DNA and suppressiveness of petite mutants in Saccharomyces cerevisiae

1971 ◽  
Vol 5 (5) ◽  
pp. 487-495 ◽  
Author(s):  
Georg Michaelis ◽  
Stephen Douglass ◽  
Ming-Jer Tsai ◽  
Richard S. Criddle
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Mitochondrial Dna ◽  
Petite Mutants

Transfer RNA genes in the mitochondrial DNA of cytoplasmic petite mutants of Saccharomyces cerevisiae

1974 ◽  
Vol 88 (4) ◽  
pp. 717-733 ◽  
Author(s):  
James W. Casey ◽  
Huey-Juang Hsu ◽  
Murray Rabinowitz ◽  
Godfrey S. Getz ◽  
Hiroshi Fukuhara
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Mitochondrial Dna ◽  
Transfer Rna ◽  
Petite Mutants ◽  
Rna Genes

scholarly journals ABNORMAL MITOCHONDRIAL GENOMES IN YEAST RESTORED TO RESPIRATORY COMPETENCE

Genetics ◽  
1978 ◽  
Vol 90 (3) ◽  
pp. 517-530
Author(s):  
K M Oakley ◽  
G D Clark-Walker
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Mitochondrial Dna ◽  
Hot Spots ◽  
High Frequency ◽  
Mitochondrial Genomes ◽  
Dna Fragments ◽  
Petite Mutants ◽  
Large Numbers

ABSTRACT When crosses are performed between newly arisen, spontaneous petite mutants of Saccharomyces cerevisiae, respiratory competent (restored) colonies can form. Some of the restored colonies are highly sectored and produce large numbers of petite mutants. The high-frequency petite formation trait is inherited in a non-Mendelian manner, and elimination of mitochondrial DNA from these strains results in the loss of the trait. These results indicate that abnormal mitochondrial genomes are sometimes formed during restoration of respiratory competence. It is hypothesized that these abnormalities result either from recombination between mitochondrial DNA fragments to produce molecules having partial duplications contained on inverted or transposed sequences, or else recombinational "hot spots" have been expanded.

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