Prt-4 and Prt-5: New constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus)

1981 ◽  
Vol 19 (5-6) ◽  
pp. 431-444 ◽  
Author(s):  
Johannes Otto ◽  
Otto von Deimling
Keyword(s):  
Gene Cluster ◽  
Submandibular Gland ◽  
House Mouse ◽  
Mus Musculus ◽  
Chromosome 7

scholarly journals The amylase gene cluster in house mice (Mus musculus) was subject to repeated introgression including the rescue of a pseudogene

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Miriam Linnenbrink ◽  
Kristian K. Ullrich ◽  
Ellen McConnell ◽  
Diethard Tautz
Keyword(s):  
Gene Cluster ◽  
House Mouse ◽  
Mus Musculus ◽  
Copy Number ◽  
Stop Codon ◽  
Natural Populations ◽  
Gene Clusters ◽  
Mus Musculus Domesticus ◽  
Amylase Gene ◽  
Copy Number Changes

Abstract Background Amylase gene clusters have been implicated in adaptive copy number changes in response to the amount of starch in the diet of humans and mammals. However, this interpretation has been questioned for humans and for mammals there is a paucity of information from natural populations. Results Using optical mapping and genome read information, we show here that the amylase cluster in natural house mouse populations is indeed copy-number variable for Amy2b paralogous gene copies (called Amy2a1 - Amy2a5), but a direct connection to starch diet is not evident. However, we find that the amylase cluster was subject to introgression of haplotypes between Mus musculus sub-species. A very recent introgression can be traced in the Western European populations and this leads also to the rescue of an Amy2b pseudogene. Some populations and inbred lines derived from the Western house mouse (Mus musculus domesticus) harbor a copy of the pancreatic amylase (Amy2b) with a stop codon in the first exon, making it non-functional. But populations in France harbor a haplotype introgressed from the Eastern house mouse (M. m. musculus) with an intact reading frame. Detailed analysis of phylogenetic patterns along the amylase cluster suggest an additional history of previous introgressions. Conclusions Our results show that the amylase gene cluster is a hotspot of introgression in the mouse genome, making it an evolutionary active region beyond the previously observed copy number changes.

Early Cold Exposure: Effects on Behavioral and Physiological Thermoregulation in the House Mouse, Mus musculus

1976 ◽  
Vol 49 (2) ◽  
pp. 191-199 ◽  
Author(s):  
G. Robert Lynch ◽  
Carol Becker Lynch ◽  
Marjory Dube ◽  
Cynthia Allen
Keyword(s):  
House Mouse ◽  
Cold Exposure ◽  
Mus Musculus

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

Mixed sex allocation strategies in a polytocous mammal, the house mouse (Mus musculus)

2011 ◽  
Vol 65 (12) ◽  
pp. 2209-2217 ◽  
Author(s):  
Adam Dušek ◽  
Luděk Bartoš ◽  
František Sedláček
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Sex Allocation ◽  
Allocation Strategies ◽  
Polytocous Mammal

scholarly journals Epigenetic polymorphism in wild populations of Mus musculus

1963 ◽  
Vol 4 (2) ◽  
pp. 193-220 ◽  
Author(s):  
R. J. Berry
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Stabilizing Selection ◽  
British Isles ◽  
Wild Populations ◽  
Local Populations ◽  
The World ◽  
Different Populations ◽  
Different Parts

It has been suggested (Berry & Searle, 1963) that the discontinuous (‘quasi-continuous’) variants studied by Grüneberg et al. in the skeleton of rodents can be regarded as constituting epigenetic polymorphism in different populations. Comparisons have been made between the incidences of skeletal variants in house mouse populations collected from: corn ricks on a single farm in Hampshire; eleven separated localities in different parts of the British Isles; and nine other places throughout the world. These showed that the method could profitably be used for genetically characterizing and hence comparing populations. There was evidence suggestive of genetical drift between local populations and stabilizing selection over a larger area.

Esterase-8 (Es-8): Characterization, polymorphism, and linkage of an erythrocyte esterase locus on chromosome 7 of Mus musculus

1974 ◽  
Vol 11 (5) ◽  
pp. 347-358 ◽  
Author(s):  
Verne M. Chapman ◽  
Elizabeth A. Nichols ◽  
Frank H. Ruddle
Keyword(s):  
Mus Musculus ◽  
Chromosome 7
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