Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14

1977 ◽  
Vol 15 (3-4) ◽  
pp. 347-355 ◽  
Author(s):  
James E. Womack ◽  
Muriel T. Davisson ◽  
Eva M. Eicher ◽  
Debra A. Kendall
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 14 ◽  
Nucleoside Phosphorylase

scholarly journals Molecular and Functional Mapping of the Piebald Deletion Complex on Mouse Chromosome 14

Genetics ◽  
2001 ◽  
Vol 157 (2) ◽  
pp. 803-815
Author(s):  
Jeffrey J Roix ◽  
Aaron Hagge-Greenberg ◽  
Dennis M Bissonnette ◽  
Sandra Rodick ◽  
Liane B Russell ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
System Development ◽  
Genomic Region ◽  
Nervous System Development ◽  
Chromosome 14 ◽  
Developmental Defects ◽  
Oak Ridge ◽  
Recessive Mutations ◽  
Large Deletions ◽  
Critical Regions

Abstract The piebald deletion complex is a set of overlapping chromosomal deficiencies surrounding the endothelin receptor B locus collected during the Oak Ridge specific-locus-test mutagenesis screen. These chromosomal deletions represent an important resource for genetic studies to dissect the functional content of a genomic region, and several developmental defects have been associated with mice homozygous for distinct piebald deletion alleles. We have used molecular markers to order the breakpoints for 20 deletion alleles that span a 15.7–18-cM region of distal mouse chromosome 14. Large deletions covering as much as 11 cM have been identified that will be useful for regionally directed mutagenesis screens to reveal recessive mutations that disrupt development. Deletions identified as having breakpoints positioned within previously described critical regions have been used in complementation studies to further define the functional intervals associated with the developmental defects. This has focused our efforts to isolate genes required for newborn respiration and survival, skeletal patterning and morphogenesis, and central nervous system development.

Mouse Chromosome 14

1999 ◽  
Vol 10 (10) ◽  
pp. 955-955
Author(s):  
Rosemary W. Elliott
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 14

scholarly journals Mapping of the neural retina leucine zipper gene, Nrl, to mouse Chromosome 14

1993 ◽  
Vol 4 (10) ◽  
pp. 618-620
Author(s):  
Irina N. Bespalova ◽  
Qais Farjo ◽  
Douglas P. Mortlock ◽  
Anne U. Jackson ◽  
Miriam H. Meisler ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Leucine Zipper ◽  
Neural Retina ◽  
Chromosome 14

scholarly journals Insertional mutation of the hairless locus on mouse Chromosome 14

1993 ◽  
Vol 4 (11) ◽  
pp. 639-643 ◽  
Author(s):  
Julie M. Jones ◽  
James T. Elder ◽  
Karl Simin ◽  
Scott A. Keller ◽  
Miriam H. Meisler
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 14 ◽  
Insertional Mutation

scholarly journals Loss of secretion in mouse-human hybrids need not be due to the loss of a structural gene.

1982 ◽  
Vol 156 (5) ◽  
pp. 1380-1389 ◽  
Author(s):  
R L Raison ◽  
K Z Walker ◽  
C R Halnan ◽  
D Briscoe ◽  
A Basten
Keyword(s):  
Pokeweed Mitogen ◽  
Optimum Dose ◽  
Structural Genes ◽  
Chromosome 14 ◽  
Human Igg ◽  
Nucleoside Phosphorylase ◽  
Heavy Chains ◽  
Hybrid Lines ◽  
Mouse Myeloma

Three cloned mouse-human lines (B1-29, E2-42, and A2-31) secreting human immunoglobulin (Ig) were obtained from a fusion between the mouse myeloma line NS-1 and human tonsillar lymphocytes stimulated in vitro with pokeweed mitogen. One line, B1-29, has continued to secrete human IgG for a period of 2 yr in culture. This line was recloned three times to give a panel of secreting and nonsecreting subclones. Most of the nonsecreting subclones had also lost surface Ig. The structural genes for human Ig heavy chains have been provisionally assigned to chromosome 14, which also encodes the enzyme nucleoside phosphorylase. Human nucleoside phosphorylase was detected in all secreting and nonsecreting B1-29 subclones, indicating the presence of human chromosome 14. The retention of chromosome 14 in nonsecreting clones implied that the structural genes for human Ig were A2-31 and E2-42, which had stopped secreting, an attempt was made to restimulate the secreting of human Ig with mitogens A2-31 was unique among the cell lines examined, in that chromosome 14 could not be detected by an isoenzyme marker. Lipopolysaccharide, at an optimum dose of 10 micrograms/ml, restimulated these nonsecreting hybrid lines to secrete human IgG in levels up to 0.7 micrograms/ml. Loss of Ig secretion may not therefore be caused by loss of Ig structural genes.

Assignment of the Transcription Factor GATA4 Gene to Human Chromosome 8 and Mouse Chromosome 14: Gata4 Is a Candidate Gene for Ds (Disorganization)

Genomics ◽  
1995 ◽  
Vol 27 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Robert A. White ◽  
Lisa L. Dowler ◽  
Linda M. Pasztor ◽  
Laura L. Gatson ◽  
Linda R. Adkison ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Human Chromosome ◽  
Candidate Gene ◽  
Mouse Chromosome ◽  
Chromosome 8 ◽  
Chromosome 14

Candidate Genes Required for Embryonic Development: A Comparative Analysis of Distal Mouse Chromosome 14 and Human Chromosome 13q22

Genomics ◽  
2002 ◽  
Vol 79 (2) ◽  
pp. 154-161 ◽  
Author(s):  
Laurie Jo Kurihara ◽  
Ekaterina Semenova ◽  
Webb Miller ◽  
Robert S. Ingram ◽  
Xiao-Juan Guan ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Embryonic Development ◽  
Human Chromosome ◽  
Candidate Genes ◽  
Mouse Chromosome ◽  
Chromosome 14 ◽  
Distal Mouse Chromosome ◽  
Distal Mouse
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