Transmission of the electronic effects of substituents by the thiophene ring

1974 ◽  
Vol 10 (7) ◽  
pp. 801-805 ◽  
Author(s):  
L. P. Pivovarevich ◽  
L. A. Kutulya ◽  
Yu. N. Surov ◽  
S. V. Tsukerman ◽  
V. F. Lavrushin
Keyword(s):  
Thiophene Ring ◽  
Electronic Effects ◽  
Electronic Effects Of Substituents

scholarly journals An Electrochemical Evaluation of Novel Ferrocene Derivatives for Glutamate and Liver Biomarker Biosensing

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 254
Author(s):  
Geok Hong Soon ◽  
Mary Deasy ◽  
Eithne Dempsey
Keyword(s):  
Film Studies ◽  
Redox Potentials ◽  
Signal Loss ◽  
Electronic Effects ◽  
Ferrocene Derivatives ◽  
Electroactive Films ◽  
Glutamate Oxidase ◽  
Electronic Effects Of Substituents ◽  
Glutamyl Transpeptidase

Here, we present an evaluation of two new monosubstituted ferrocene (Fc) derivatives, 3-(1H-pyrrol-1-yl)propanamidoferrocene and 1-hydroxy-2-[2-(thiophen-3-yl)-ethylamino]ethylferrocene, as glutamate oxidase mediators, together with their preparation and characterisation. Taking into consideration the influence of the electronic effects of substituents on the redox potentials of the Fc species, two candidates with pyrrole or thiophene moieties were proposed for investigation. Film studies involved potential sweeping in the presence of pyrrole or 3,4-ethylenedioxythiophene monomers resulting in stable electroactive films with % signal loss upon cycling ranging from 1 to 7.82% and surface coverage (Γ) 0.47–1.15 × 10−9 mol/cm2 for films formed under optimal conditions. Construction of a glutamate oxidase modified electrode resulted in second-generation biosensing with the aid of both cyclic voltammetry and hydrodynamic amperometry, resulting in glutamate sensitivity of 0.86–1.28 μA/mM and Km (app) values over the range 3.67–5.01 mM. A follow-up enzyme assay for liver biomarker γ-glutamyl transpeptidase realised unmediated and mediated measurement establishing reaction and incubation time investigations and a realising response over <100 U/L γ-glutamyl transpeptidase with a sensitivity of 5 nA/UL−1.

Correlation of structural parameters with antituberculotic activity in a group of 2-benzamidobenzothiazoles

1991 ◽  
Vol 56 (12) ◽  
pp. 2978-2985 ◽  
Author(s):  
Karel Waisser ◽  
Jiří Kuneš ◽  
Želmíra Odlerová
Keyword(s):  
Structural Parameters ◽  
Regression Equations ◽  
Electronic Effects ◽  
Active Compounds ◽  
Qsar Analysis ◽  
Active Structures ◽  
Benzoyl Group ◽  
Electronic Effects Of Substituents

Fourteen 2-benzamidobenzothiazole derivatives substituted in the benzoyl group and 2-cinnamamidobenzothiazole have been synthesized. The prediction of active structures by the method by Topliss gives incorrect results but, as shown on the basis of the Hansch QSAR analysis, the 2-(4-dimethylaminobenzamido)benzothiazole synthesized on the basis of the QSAR procedure by Topliss behaves anomalously also in the procedure by Hansch. Regression equations of the Hansch type have been found in which the antituberculotic activity is interpreted by lipophilicity and electronic effects of substituents. When tested in vitro, the most active compounds are comparable with ethionamide.

Radical Metal-Free Borylation of Aryl Iodides

Synthesis ◽  
2017 ◽  
Vol 49 (21) ◽  
pp. 4759-4768 ◽  
Author(s):  
Sandra Pinet ◽  
Mathieu Pucheault ◽  
Virginie Liautard ◽  
Mégane Debiais
Keyword(s):  
Steric Hindrance ◽  
Radical Mechanism ◽  
Electronic Effects ◽  
Simple Metal ◽  
Reaction Conditions ◽  
Metal Free ◽  
Aryl Iodides ◽  
Reaction Proceeds ◽  
Electronic Effects Of Substituents

A simple metal-free borylation of aryl iodides mediated by a fluoride sp2–sp3 diboron adduct is described. The reaction conditions are compatible with various functional groups. Electronic effects of substituents do not affect the borylation while steric hindrance does. The reaction proceeds via a radical mechanism in which pyridine serves to stabilize the boryl radicals, generated in situ.

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