Structure of the cationic forms of pyrimido [4,5-b][1,4]thiazines ? A new type of folic acid antagonist

1979 ◽  
Vol 15 (1) ◽  
pp. 41-46
Author(s):  
G. G. Dvoryantseva ◽  
T. N. Ul'yanova ◽  
T. Ya. Filipenko ◽  
M. P. Nemeryuk ◽  
T. S. Safonova ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Antagonist ◽  
Acid Antagonist ◽  
New Type

Pyrimido(4,5-b)(1,4)thiazine derivatives. A new type of folic acid antagonist

1975 ◽  
Vol 9 (4) ◽  
pp. 227-230
Author(s):  
N. A. Ryabokon' ◽  
N. A. Andreeva ◽  
M. P. Nemeryuk ◽  
A. F. Keremov ◽  
V. A. Chernov ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Antagonist ◽  
Acid Antagonist ◽  
New Type

Pteridinosteroids. A new type of folic acid antagonist with lipid solubility

Steroids ◽  
1963 ◽  
Vol 2 (1) ◽  
pp. 105-110 ◽  
Author(s):  
T.J. Bardos ◽  
Z.F. Chmielewicz ◽  
S.P. Raman ◽  
A. Segaloff
Keyword(s):  
Folic Acid ◽  
Lipid Solubility ◽  
Folic Acid Antagonist ◽  
Acid Antagonist ◽  
New Type

The Use of Methotrexate in Rheumatoid Arthritis

1985 ◽  
Vol 19 (5) ◽  
pp. 349-358 ◽  
Author(s):  
Peter W. Letendre ◽  
Douglas J. DeJong ◽  
Donald R. Miller
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Folic Acid ◽  
Side Effects ◽  
Adverse Effects ◽  
Systemic Administration ◽  
Refractory Disease ◽  
Controlled Clinical Trials ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5–15 mg/wk in a “pulse” fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded.

Folic acid antagonist use before and during pregnancy and risk for selected birth defects

2020 ◽  
Vol 112 (18) ◽  
pp. 1526-1540
Author(s):  
Stephen M. Kerr ◽  
Samantha E. Parker ◽  
Allen A. Mitchell ◽  
Sarah C. Tinker ◽  
Martha M. Werler
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

Precipitation of Menstrual Bleeding in Monkeys by a Folic Acid Antagonist

Science ◽  
1950 ◽  
Vol 112 (2901) ◽  
pp. 147-147 ◽  
Author(s):  
M. X. Zarrow ◽  
F. L. Hisaw ◽  
H. A. Salhanick
Keyword(s):  
Folic Acid ◽  
Menstrual Bleeding ◽  
Folic Acid Antagonist ◽  
Acid Antagonist
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